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Current Cancer Research

D-type Cyclins and Cancer

Editors: Hinds, Philip W., Brown, Nelson E. (Eds.)

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  • Provides emphasis on functional aspects of D-type cyclins on mammalian tissue 
    Reviews existing mouse models of cyclin D-deficiency 
    Discusses potential of D-type cyclins as feasible therapeutic cancer targets

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eBook 118,99 €
price for Spain (gross)
  • ISBN 978-3-319-64451-6
  • Digitally watermarked, DRM-free
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  • Immediate eBook download after purchase
Hardcover 155,99 €
price for Spain (gross)
  • ISBN 978-3-319-64449-3
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
  • The final prices may differ from the prices shown due to specifics of VAT rules
Softcover 155,99 €
price for Spain (gross)
  • ISBN 978-3-319-87797-6
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
  • The final prices may differ from the prices shown due to specifics of VAT rules
About this book

This volume provides an integrated account of our current understanding of the functions of D-type cyclins during development and tumorigenesis, with special emphasis on the kinase-independent functions of these proteins. The volume will provide a thorough review of the latest discoveries on the new functions and interacting partners of mammalian cyclin Ds crucial to explain their oncogenic and differentiation properties in different cellular contexts. The volume begins with a historical perspective of how D-type cyclins were first discovered and eventually cloned from cancer tissues, followed by an account on the canonical functions of cyclin Ds during the G1-S transition of the cell cycle. Several chapters will be devoted to review the functions of D-type cyclins as transcriptional regulators and the mechanisms through which these novel functions could impact the tumorigenic process. Also discussed is emerging evidence that points to a role of D-type cyclins, particularly cyclin D1, as a cytoplasmic regulator of various cellular functions. This property, in human cells at least, is traceable to certain splice isoforms with novel oncogenic implications. Finally, a chapter is devoted to recent efforts to revise the canonical view of the “retinoblastoma pathway” to incorporate new evidence that suggests that cyclin D1’s role in G1 is to singly-phosphorylate the retinoblastoma protein (pRb) for discrimination of target protein interactions. This work represents a significant departure from the view of cyclin D1 as a negative regulator of pRb and may have critical implications for understanding the function of antineoplastic agents that target the cyclin D1-associated kinases.

About the authors

Philip W. Hinds is Professor and Chair of the Department of Developmental, Molecular and Chemical Biology at Tufts University School of Medicine. He is also the Deputy Director of Tufts Medical Cancer Center. Dr. Hinds is an expert in cell cycle control and its dysregulation in cancer cells. He participates in several journal editorial boards including the Journal of Biological Chemistry, the Chinese Journal of Cancer, and Cancer Research to name a few. 

Nelson E. Brown is currently Associate Professor at the University of Talca School of Medicine in Chile. He is also Director of the Center for Medical Research at the University of Talca.​ His current work focuses on the role of cyclin D1-associated kinase activity in senescence and tumorigenesis

Table of contents (6 chapters)

Table of contents (6 chapters)
  • The D-Type Cyclins: A Historical Perspective

    Pages 1-26

    Sherr, Charles J. (et al.)

  • Mammalian Development and Cancer: A Brief History of Mice Lacking D-Type Cyclins or CDK4/CDK6

    Pages 27-59

    Kalaszczynska, Ilona (et al.)

  • D-Type Cyclins and Gene Transcription

    Pages 61-90

    Sante, Gabriele (et al.)

  • Splice Variants and Phosphorylated Isoforms of Cyclin D1 in Tumorigenesis

    Pages 91-109

    Diehl, J. Alan (et al.)

  • Cyclin D1, Metabolism, and the Autophagy-Senescence Balance

    Pages 111-131

    Valenzuela, Claudio, PhD (et al.)

Buy this book

eBook 118,99 €
price for Spain (gross)
  • ISBN 978-3-319-64451-6
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover 155,99 €
price for Spain (gross)
  • ISBN 978-3-319-64449-3
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
  • The final prices may differ from the prices shown due to specifics of VAT rules
Softcover 155,99 €
price for Spain (gross)
  • ISBN 978-3-319-87797-6
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
  • The final prices may differ from the prices shown due to specifics of VAT rules
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Bibliographic Information

Bibliographic Information
Book Title
D-type Cyclins and Cancer
Editors
  • Philip W. Hinds
  • Nelson E. Brown
Series Title
Current Cancer Research
Copyright
2018
Publisher
Humana Press
Copyright Holder
Springer International Publishing AG
eBook ISBN
978-3-319-64451-6
DOI
10.1007/978-3-319-64451-6
Hardcover ISBN
978-3-319-64449-3
Softcover ISBN
978-3-319-87797-6
Series ISSN
2199-2584
Edition Number
1
Number of Pages
IX, 152
Number of Illustrations
4 b/w illustrations, 25 illustrations in colour
Topics