Energy Balance and Cancer

Focus on Gynecologic Malignancies

Editors: Berger, Nathan, Klopp, Ann, Lu, Karen (Eds.)

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  • Examines the relation of obesity to endometrial cancer and to ovarian cancer while providing insight into public understanding of the importance of obesity as a risk factor for gynecologic malignancies 
  • Describes major aspects of biology relating obesity to gynecologic cancer including hormonal status, adipokines, adipose stromal cells and in particular, use of model systems to study the impact of obesity in gynecologic malignancies 
  • Discusses the multiple prevention strategies including hormone and lifestyle interventions, extending even to bariatric surgery, along with detailed effects of the impact of obesity on treatment strategies and approach to unique outcomes
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Buy this book

eBook 142,79 €
price for Spain (gross)
  • ISBN 978-3-319-63483-8
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover 176,79 €
price for Spain (gross)
  • ISBN 978-3-319-63482-1
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
  • The final prices may differ from the prices shown due to specifics of VAT rules
Softcover 176,79 €
price for Spain (gross)
  • ISBN 978-3-319-87569-9
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
  • The final prices may differ from the prices shown due to specifics of VAT rules
About this book

Gynecologic malignancies, especially endometrial and ovarian cancers are among the most important and most severely affected by obesity. This volume of Energy Balance and Cancer, written by the world’s leading experts in this field, is arranged to provide a transdisciplinary assessment of the pertinent issues, results of relevant research on mechanisms, and control, strategies for dealing with affected patients and improving outcomes and future research needs. The volume comprehensively covers the epidemiology linking obesity to endometrial and ovarian cancer as well as the public awareness of this critical problem. Subsequent chapters explain biologic aspects of linkages between energy balance and gynecologic malignancies. The volume further outlines strategies to disrupt the linkage between obesity and gynecologic malignancies and concludes with a series of chapters focused on management strategies for obese patients with gynecologic malignancies. 

This volume provides a valuable resource for all physicians, scientists and other transdisciplinary investigators and practitioners interested and involved in energy balance and cancer. It should be a particularly useful guide to optimize outcomes for all practitioners dealing with patients with gynecologic malignancies challenged by energy balance issues. Moreover, it should serve as a useful guide to students and investigators interested in conducting further research on defining and disrupting the important linkage between energy balance and gynecologic malignancies.

About the authors

Nathan A. Berger, MD, Distinguished University Professor and Hanna-Payne Professor of Experimental Medicine, Biochemistry, Genetics and Oncology, is Director of the Case Western Reserve University Center for Science, Health and Society. He obtained the MD degree from Hahnemann University, Philadelphia, PA, interned at Michael Reese Medical Center, Chicago, IL, and served as a medical resident and Hematology/Oncology Fellow at Washington University, St. Louis, MO. Dr. Berger was a research associate in the Laboratory of Molecular Biology, Gerontology Research Center, NICHD, NIH, Baltimore, MD. He was on the faculty at Washington University School of Medicine, before moving to Case Western Reserve University School of Medicine where he served consecutively as Chief, Hematology/Oncology Division, Cancer Center Director, Dean, CWRU School of Medicine and now Director, Center for Science, Health and Society. His research focuses on model systems to study impact of diet, obesity and exercise on aging and cancer and studies to translate and evaluate these observations in human subjects

Karen H. Lu, MD, is Professor in the Department of Gynecologic Oncology and Reproductive Medicine at The University of Texas MD Anderson Cancer Center, Houston, TX, where she holds the J. Taylor Wharton Distinguished Chair in Gynecologic Oncology. Her main clinical interests include the surgical and medical treatment of women with ovarian and endometrial cancers, as well as the management of women at genetically high risk for these cancer. Dr. Lu completed her undergraduate training at Harvard University and received her MD degree from Yale University School of Medicine. She completed her Obstetrics and Gynecology training at The Brigham and Women’s Hospital and Massachusetts General Hospital, Harvard Medical School. She serves as Co-Director for the MD Anderson Clinical Cancer Genetics Program and Director of the High Risk Ovarian Cancer Screening Clinic. She is a national leader in the cancer genetics field and has published seminal articles on hereditary gynecologic cancers. In addition, she serves as Director of the Uterine Cancer Research Program (UCRP) and Principal Investigator of the NCI-sponsored Uterine Cancer Specialized Program of Research Excellence (SPORE). She leads a research team that aims to apply laboratory-based findings to improve the care of gynecologic cancer patients. She serves on the American Society of Clinical Oncology (ASCO) Cancer Prevention Committee, the NCI PDQ Editorial Board for Cancer Genetics and the American College of Obstetricians and Gynecologists (ACOG) Committee on Gynecological Practice Bulletins.

Ann H. Klopp, MD, PhD, is an Associate Professor of Radiation Oncology at The University of Texas MD Anderson Cancer Center, Houston, TX. She is a physician-scientist specializing in the treatment of gynecologic cancers with laboratory research focus on energy balance and gynecologic malignancies. Clinically, she is interested in the management of high-risk endometrial and cervical cancers and the use of advanced radiation techniques to minimize toxicity. She leads the Global Oncology program in the Division of Radiation Oncology. She has extensive experience with clinical trials, serving as the PI on a phase III randomized study through the NRG as well as multiple investigator initiated single arm prospective studies at MD Anderson.  She is a member of the Corpus steering committee at NRG and the Uterine Task Force of the Gynecologic Cancer Steering Committee at NIH. Her current laboratory research on the impact of obesity and the microenvironment on gynecologic cancers using clinical specimens and murine models is funded by CPRIT, the American Cancer Society and the HPV moonshot program at MD Anderson Cancer Center. 

 



Reviews

“This is a comprehensive resource examining the link between obesity and gynecological malignancies, specifically endometrial and ovarian cancers. … This is a valuable reference for clinicians treating patients with gynecological malignancies as well as those dealing with diabetes and obesity among their patients. Needless to say, basic and translational scientists and other investigators and practitioners working on elucidating the link between energy balance and cancer also may find this book very helpful.” (Ravi Salgia, Doody's Book Reviews, July, 2018)

Table of contents (16 chapters)

Table of contents (16 chapters)
  • Epidemiologic Evidence for the Obesity-Endometrial Cancer Relationship

    Merritt, Melissa A. (et al.)

    Pages 1-19

  • Epidemiologic Relationship Between Obesity and Ovarian Cancer

    Jochem, Carmen (et al.)

    Pages 21-30

  • Public Knowledge of Obesity and Gynecologic Cancer Risk

    Armbruster, Shannon (et al.)

    Pages 31-40

  • Role of Estrogen and Progesterone in Obesity Associated Gynecologic Cancers

    Brinton, Louise A., Ph.D. (et al.)

    Pages 41-61

  • Obesity and Endometrial Cancer Precursors

    Watkins, Jaclyn, M.D., M.S.

    Pages 63-71

Buy this book

eBook 142,79 €
price for Spain (gross)
  • ISBN 978-3-319-63483-8
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover 176,79 €
price for Spain (gross)
  • ISBN 978-3-319-63482-1
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
  • The final prices may differ from the prices shown due to specifics of VAT rules
Softcover 176,79 €
price for Spain (gross)
  • ISBN 978-3-319-87569-9
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
  • The final prices may differ from the prices shown due to specifics of VAT rules
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Bibliographic Information

Bibliographic Information
Book Title
Focus on Gynecologic Malignancies
Editors
  • Nathan Berger
  • Ann Klopp
  • Karen Lu
Series Title
Energy Balance and Cancer
Series Volume
13
Copyright
2018
Publisher
Springer International Publishing
Copyright Holder
Springer International Publishing AG, part of Springer Nature
eBook ISBN
978-3-319-63483-8
DOI
10.1007/978-3-319-63483-8
Hardcover ISBN
978-3-319-63482-1
Softcover ISBN
978-3-319-87569-9
Series ISSN
2199-2622
Edition Number
1
Number of Pages
XIII, 312
Number of Illustrations
2 b/w illustrations, 15 illustrations in colour
Topics