Overview
- Provides new insights into the development of tailored transport systems for the targeted drug delivery into mammalian cells
- Reviews the key recent research on the role of cellular receptors, toxin pores and host cell chaperones for the uptake of bacterial protein toxins into cells
- Promotes the development of novel pharmacological strategies to protect cells from intoxication
Part of the book series: Current Topics in Microbiology and Immunology (CT MICROBIOLOGY, volume 406)
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Table of contents (9 chapters)
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Front Matter
Keywords
About this book
This volume focuses on the transport of medically relevant bacterial protein toxins into mammalian cells, and on novel pharmacological strategies to inhibit toxin uptake. The first chapters review our current understanding of the cell-surface receptors and cellular transport processes of Clostridium botulinum neurotoxins, Clostridium botulinum C3 toxin, Clostridium difficile toxins, binary clostridial enterotoxins, anthrax toxins and diphtheria toxin. In brief, specific binding/transport (B) subunits deliver the enzyme (A) subunits into the cytosol, where the latter modify their substrates, producing cytotoxic effects and the characteristic toxin-associated diseases. Key mechanisms for the transport of the A subunits from endosomes into the cytosol and the role of trans-membrane pores formed by the B subunits and host cell chaperones for this process are reviewed. The book’s closing chapters focus on compounds which inhibit the transport of the A subunits from endosomes into the cytosol and therefore might lead to novel therapeutic strategies for toxin-associated diseases. These substances include pharmacological inhibitors of the host cell chaperones involved, as well as multivalent and heterocyclic molecules that specifically block the toxins’ translocation channels. This volume offers an up-to-date resource for scientists.
Editors and Affiliations
About the editor
Holger Barth
Institute of Pharmacology and Toxicology, University of Ulm Medical Center, Albert-Einstein-Allee 11, 89081 Ulm, Germany, e-mail: holger.barth@uni-ulm.de
Bibliographic Information
Book Title: Uptake and Trafficking of Protein Toxins
Editors: Holger Barth
Series Title: Current Topics in Microbiology and Immunology
DOI: https://doi.org/10.1007/978-3-319-58893-3
Publisher: Springer Cham
eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)
Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Switzerland AG 2017
Hardcover ISBN: 978-3-319-58891-9Published: 19 December 2017
Softcover ISBN: 978-3-319-86502-7Published: 30 August 2018
eBook ISBN: 978-3-319-58893-3Published: 01 December 2017
Series ISSN: 0070-217X
Series E-ISSN: 2196-9965
Edition Number: 1
Number of Pages: VII, 256
Topics: Medical Microbiology, Pharmacology/Toxicology, Infectious Diseases