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  • © 2017

Complexity and Nonlinearity in Cardiovascular Signals

  • Expertly reviews cutting-edge research, such as recent advances in multiscale entropy and information-theoretic concepts applied to coupled dynamical systems
  • Comprehensively describes applications of analytic technique to clinical scenarios such as heart failure, depression and mental disorders, atrial fibrillation, acute brain lesions, and more
  • Broadens readers' understanding of cardiovascular signals, heart rate complexity, heart rate variability, and nonlinear analysis
  • Includes supplementary material: sn.pub/extras
  • Includes supplementary material: sn.pub/extras

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Table of contents (19 chapters)

  1. Front Matter

    Pages i-viii
  2. Introduction

    1. Front Matter

      Pages 1-1
    2. Introduction to Complex Cardiovascular Physiology

      • Michele Orini, Riccardo Barbieri, Mimma Nardelli, Enzo Pasquale Scilingo, Gaetano Valenza
      Pages 3-42
  3. Methods

    1. Front Matter

      Pages 43-43
    2. Multiscale Entropy: Recent Advances

      • Meng Hu, Hualou Liang
      Pages 115-138
    3. Introduction to Complex Systems Analysis with Wavelets

      • Nicola Vanello, Luigi Landini
      Pages 139-159
    4. Intermittency-Driven Complexity in Signal Processing

      • Paolo Paradisi, Paolo Allegrini
      Pages 161-195
    5. Self-Similarity and Detrended Fluctuation Analysis of Cardiovascular Signals

      • Paolo Castiglioni, Marco Di Rienzo, Andrea Faini
      Pages 197-232
    6. Time-Varying Cardiovascular Complexity with Focus on Entropy and Lyapunov Exponents

      • Gaetano Valenza, Luca Citi, Enzo Pasquale Scilingo, Riccardo Barbieri
      Pages 233-256
    7. Time-Frequency Analysis of Cardiovascular Signals and Their Dynamic Interactions

      • Michele Orini, Pablo Laguna, Luca T. Mainardi, Raquel Bailón
      Pages 257-287
  4. Applications

    1. Front Matter

      Pages 289-289
    2. Applications of Complexity Analysis in Clinical Heart Failure

      • Chengyu Liu, Alan Murray
      Pages 301-325
    3. Heart Rate Complexity Associated with Diabetic Cardiac Neuropathy

      • Herbert F. Jelinek, David J. Cornforth
      Pages 327-344
    4. Applications of Heartbeat Complexity Analysis to Depression and Bipolar Disorder

      • Gaetano Valenza, Luca Citi, Antonio Lanata, Claudio Gentili, Riccardo Barbieri, Enzo Pasquale Scilingo
      Pages 345-374
    5. Cardiac Autonomic Changes in Epilepsy

      • Andrea Romigi, Nicola Toschi
      Pages 375-386
    6. Applications of Nonlinear Methods to Atrial Fibrillation

      • Raúl Alcaraz, José J. Rieta
      Pages 387-426
    7. Complex and Nonlinear Analysis of Heart Rate Variability in the Assessment of Fetal and Neonatal Wellbeing

      • Maria G. Signorini, Giovanni Magenes, Manuela Ferrario, Maristella Lucchini
      Pages 427-450

About this book

This book reports on the latest advances in complex and nonlinear cardiovascular physiology aimed at  obtaining reliable, effective markers for the assessment of heartbeat, respiratory, and blood pressure dynamics. The chapters describe in detail methods that have been previously defined in theoretical physics such as entropy, multifractal spectra, and Lyapunov exponents, contextualized within physiological dynamics of cardiovascular control, including autonomic nervous system activity. Additionally, the book discusses several application scenarios of these methods. The text critically reviews the current state-of-the-art research in the field that has led to the description of dedicated experimental protocols and ad-hoc models of complex physiology. This text is ideal for biomedical engineers, physiologists, and neuroscientists. 

This book also:

Expertly reviews cutting-edge research, such as recent advances in measuring complexity, nonlinearity, and information-theoretic concepts applied to coupled dynamical systems

Comprehensively describes applications of analytic technique to clinical scenarios such as heart failure, depression and mental disorders, atrial fibrillation, acute brain lesions, and more

Broadens readers' understanding of cardiovascular signals, heart rate complexity, heart rate variability, and nonlinear analysis

Editors and Affiliations

  • Department of Electronics, Informatics and Bioengineering, Politecnico di Milano, Milan, Italy

    Riccardo Barbieri

  • Department of Information Engineering & Bioengineering and Robotics Research Center “E. Piaggio”, University of Pisa, School of Engineering, Pisa, Italy

    Enzo Pasquale Scilingo, Gaetano Valenza

About the editors

Riccardo Barbieri is a Professor in the Department of Electronics, Informatics and Bioengineering at the Politecnico di Milano, in Milan, Italy. 


Enzo P. Scilingo and Gaetano Valenza are both Professors at the Department of Information Engineering & Bioengineering and Robotics Research Center "E. Piaggio", at University of Pisa School of Engineering, in Pisa, Italy.

Bibliographic Information

Buy it now

Buying options

eBook USD 189.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book USD 249.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book USD 249.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Other ways to access