Epigenetics of Infectious Diseases

1. Front Matter

   Pages i-viii

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2. DNA Methylation of Human Papillomavirus Genomes During Infection and Cancer Progression

   • Hans-Ulrich Bernard

   Pages 1-14

3. Epigenetic Regulation of Gammaherpesviruses: A Focus on Kaposi’s Sarcoma-Associated Herpesvirus (KSHV/HHV-8)

   • Rosha Poudyal, Rolf Renne, Michael P. Kladde

   Pages 15-46

4. Discoveries in Molecular Genetics with the Adenovirus 12 System: Integration of Viral DNA and Epigenetic Consequences

   • Walter Doerfler

   Pages 47-63

5. Epigenetic Consequences of Epstein–Barr Virus Infection

   • Christine E. Birdwell, Krista Queen, Rona S. Scott

   Pages 65-87

6. Epigenetic Programming by Microbial Pathogens and Impacts on Acute and Chronic Disease

   • Michael J. Mahan, Douglas M. Heithoff, Lucien Barnes V, Robert L. Sinsheimer

   Pages 89-112

7. Cross Talk Between Bacteria and the Host Epigenetic Machinery

   • Hélène Bierne

   Pages 113-158

8. Epigenetic Phase Variation in Bacterial Pathogens

   • Marjan W. van der Woude

   Pages 159-173

9. Epigenetic Switching in the Human Fungal Pathogen Candida albicans

   • Han Du, Guanghua Huang

   Pages 175-187

10. Modification of the Host Epigenome by Parasitic Protists

    • Inessa Gendlina, Natalie Silmon de Monerri, Kami Kim

    Pages 189-220

11. Epigenetic Regulation in T. brucei: Changing Coats Is a Chance to Survive

    • Ana C. Pena, Francisco Aresta-Branco, Luísa M. Figueiredo

    Pages 221-241

12. Epigenetics of Malaria Parasites

    • Evelien M. Bunnik, Karine G. Le Roch

    Pages 243-264

13. Back Matter

    Pages 265-277

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The present volume of Epigenetics and Human Health is devoted to the patho-epigenetics of viral and microbial infections, an exiting new field of disease-related epigenetic research. As recognized during the past years, epigenetic reprogramming of pathogen and host genome functions – the latter frequently induced by pathogens – plays an important role in many infectious processes. Beyond their immediate relevance for pathogen proliferation and obligatorily associated symptoms, such alterations frequently contribute to severe additional complications, such as the development of immunodeficiency, cancer and various chronic disorders. This holds in particular for epigenetic dysregulation of host gene expression induced by latent infections. The present book summarizes current knowledge of the mechanisms underlying epigenetic changes caused by viral, bacterial, fungal and protozoan infections and their impact on human health.

• bacterial infections
• infected viral genomes
• integrated viral genomes
• parasitic protozoa
• protist infections
• virus-induced tumor cells

• Institute for Clinical and Molecular Virology, University Erlangen-Nürnberg Medical School, Erlangen, Germany

  Walter Doerfler

• Departamento de Genética, Universidad de Sevilla, Sevilla, Spain

  Josep Casadesús

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