Current Cancer Research

Asbestos and Mesothelioma

Editors: Testa, Joseph R. (Ed.)

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  • Disseminates for the first time information from a study demonstrating that inherited mutations can influence a person’s risk of mesothelioma
  • Addresses the fact that, besides mesothelioma, some of the BAP1 mutation carriers developed ocular melanoma or other cancers, and this cancer susceptibility is now recognized as the BAP1 Syndrome
  • Highlights will be the various molecular signaling pathways that are hyper-activated in this disease, facilitating the identification of novel druggable targets for cancer therapy or prevention
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About this book

This volume is comprised of a multidisciplinary assessment of the interplay between asbestos and cancer as well as new research about the biology and treatment of malignant mesothelioma.  Chapters on the various types of asbestos and other mineral fibers, epidemiology, history and future of asbestos-related diseases are included.  Other reviews present new information about the role of asbestos-related inflammation and genetic factors, including the role of inherited mutations of BAP1, in mesothelioma causation, as well as recent research about gene signatures, cell signaling, and epigenetic mechanisms in asbestos-related diseases.  Other chapters provide updates of novel disease biomarkers and prevention, mechanistic lesson from genetically engineered mouse and 3-D models of mesothelioma tumorigenesis and therapeutic resistance.  Also included are up-to-date reviews of surgical, molecularly targeted chemotherapeutic, and immunotherapeutic approaches for mesothelioma as well as an overview of legal issues.

About the authors

Joseph R. Testa, PhD, FACMG is Senior Member/Professor, Carol and Kenneth E. Weg Chair in Human Genetics, Chief of Laboratory Genetics, and Co-Leader of the Cancer Biology Program at Fox Chase Cancer Center, Philadelphia, PA. His research interests focus on mesothelioma pathogenesis and AKT-related oncogenesis. He has published numerous papers and reviews, and serves on the editorial boards of several journals, including as Senior Editor for Cancer Research. He has received multiple science awards, including the J. Christopher Wagner Medal from the International Mesothelioma Interest Group and the Pioneer Research Award from the Mesothelioma Applied Research Foundation. He is also a Fellow of the American Association for the Advancement of Science.

Table of contents (18 chapters)

Table of contents (18 chapters)
  • Malignant Mesothelioma: An Asbestos Legacy

    Pages 1-9

    Testa, Joseph R.

  • Asbestos and Fibrous Erionite

    Pages 11-41

    Wylie, Ann G.

  • Epidemiology of Mesothelioma

    Pages 43-72

    Moolgavkar, Suresh H. (et al.)

  • Malignant Pleural Mesothelioma: History, Controversy, and Future of a Man-Made Epidemic

    Pages 73-101

    Røe, Oluf Dimitri (et al.)

  • Communities at High Risk in the Third Wave of Mesothelioma

    Pages 103-130

    Emmett, Edward A. (et al.)

Buy this book

eBook n/a
  • ISBN 978-3-319-53560-9
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
Hardcover n/a
  • ISBN 978-3-319-53558-6
  • Free shipping for individuals worldwide
Softcover n/a
  • ISBN 978-3-319-85183-9
  • Free shipping for individuals worldwide
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Bibliographic Information

Bibliographic Information
Book Title
Asbestos and Mesothelioma
Editors
  • Joseph R. Testa
Series Title
Current Cancer Research
Copyright
2017
Publisher
Springer International Publishing
Copyright Holder
Springer International Publishing AG
eBook ISBN
978-3-319-53560-9
DOI
10.1007/978-3-319-53560-9
Hardcover ISBN
978-3-319-53558-6
Softcover ISBN
978-3-319-85183-9
Series ISSN
2199-2584
Edition Number
1
Number of Pages
VIII, 407
Number of Illustrations
22 b/w illustrations, 43 illustrations in colour
Topics