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Advances in Experimental Medicine and Biology

Systems Biology of Tumor Microenvironment

Quantitative Modeling and Simulations

Editors: Rejniak, Katarzyna A. (Ed.)

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  • First book devoted entirely to quantitative modeling of tumor microenvironment
  • Includes examples of integration between math modeling and cancer experiments that can be followed in readers' research
  • Gives the reader a compendium knowledge of a current state of the art in systems biology of tumor microenvironment
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  • ISBN 978-3-319-42023-3
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Hardcover 166,39 €
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Softcover 166,39 €
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  • ISBN 978-3-319-82480-2
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About this book

This edited volume discusses the complexity of tumor microenvironments during cancer development, progression and treatment. Each chapter presents a different mathematical model designed to investigate the interactions between tumor cells and the surrounding stroma and stromal cells. The topics covered in this book include the quantitative image analysis of a tumor microenvironment, the microenvironmental barriers in oxygen and drug delivery to tumors, the development of tumor microenvironmental niches and sanctuaries, intravenous transport of the circulating tumor cells, the role of the tumor microenvironment in chemotherapeutic interventions, the interactions between tumor cells, the extracellular matrix, the interstitial fluid, and the immune and stromal cells. Mathematical models discussed here embrace both continuous and agent-based approaches, as well as mathematical frameworks of solid mechanics, fluid dynamics and optimal control theory. The topics in each chapter will be of interest to a biological community wishing to apply the mathematical methods to interpret their experimental data, and to a biomathematical audience interested in exploring how mathematical models can be used to address complex questions in cancer biology.

 

About the authors

PhD: Tulane University, Department of Mathematics, 2002

Postdoctoral Fellow: Mathematical Biosciences Institute, OSU, Columbus Ohio

Postdoctoral Researcher: University of Dundee, Scotland 






Table of contents (12 chapters)

Table of contents (12 chapters)
  • Image Analysis of the Tumor Microenvironment

    Pages 1-10

    Lloyd, Mark C. (et al.)

  • Hypoxia in Gliomas: Opening Therapeutical Opportunities Using a Mathematical-Based Approach

    Pages 11-29

    Martı́nez-González, Alicia (et al.)

  • Computer Simulations of the Tumor Vasculature: Applications to Interstitial Fluid Flow, Drug Delivery, and Oxygen Supply

    Pages 31-72

    Welter, Michael (et al.)

  • Cell-ECM Interactions in Tumor Invasion

    Pages 73-91

    He, Xiuxiu (et al.)

  • Circulating Tumor Cells: When a Solid Tumor Meets a Fluid Microenvironment

    Pages 93-106

    Rejniak, Katarzyna A.

Buy this book

eBook 128,39 €
price for Spain (gross)
  • ISBN 978-3-319-42023-3
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover 166,39 €
price for Spain (gross)
  • ISBN 978-3-319-42021-9
  • Free shipping for individuals worldwide
  • Immediate ebook access, if available*, with your print order
  • Usually dispatched within 3 to 5 business days.
  • The final prices may differ from the prices shown due to specifics of VAT rules
Softcover 166,39 €
price for Spain (gross)
  • ISBN 978-3-319-82480-2
  • Free shipping for individuals worldwide
  • Immediate ebook access, if available*, with your print order
  • Usually dispatched within 3 to 5 business days.
  • The final prices may differ from the prices shown due to specifics of VAT rules
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Bibliographic Information

Bibliographic Information
Book Title
Systems Biology of Tumor Microenvironment
Book Subtitle
Quantitative Modeling and Simulations
Editors
  • Katarzyna A. Rejniak
Series Title
Advances in Experimental Medicine and Biology
Series Volume
936
Copyright
2016
Publisher
Springer International Publishing
Copyright Holder
Springer International Publishing Switzerland
eBook ISBN
978-3-319-42023-3
DOI
10.1007/978-3-319-42023-3
Hardcover ISBN
978-3-319-42021-9
Softcover ISBN
978-3-319-82480-2
Series ISSN
0065-2598
Edition Number
1
Number of Pages
XVII, 249
Number of Illustrations
13 b/w illustrations, 80 illustrations in colour
Topics

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