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Healthy Ageing and Longevity

Cellular Ageing and Replicative Senescence

Editors: Rattan, Suresh I.S., Hayflick, Leonard (Eds.)

  • Provides a review of historical development of ideas in cellular ageing and replicative senescence
  • Presents a discussion of ageing and cancer in cell proliferation regulation
  • Explains usage of the cellular ageing model system for testing ageing modulators or anti-ageing compounds
  • Offers practical suggestions for future research and development in human health and disease
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eBook 118,99 €
price for Spain (gross)
  • ISBN 978-3-319-26239-0
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover 155,99 €
price for Spain (gross)
  • ISBN 978-3-319-26237-6
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
  • The final prices may differ from the prices shown due to specifics of VAT rules
Softcover 155,99 €
price for Spain (gross)
  • ISBN 978-3-319-79912-4
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
  • The final prices may differ from the prices shown due to specifics of VAT rules
About this book

This book covers the origins and subsequent history of research results in which attempts have been made to clarify issues related to cellular ageing, senescence, and age-related pathologies including cancer. Cellular Ageing and Replicative Senescence revisits more than fifty-five years of research based on the discovery that cultured normal cells are mortal and the interpretation that this phenomenon is associated with the origins of ageing. The mortality of normal cells and the immortality of cancer cells were also reported to have in vivo counterparts. Thus began the field of cytogerontology.
Cellular Ageing and Replicative Senescence is organized into five sections: history and origins; serial passaging and progressive ageing; cell cycle arrest and senescence; system modulation; and recapitulation and future expectations. These issues are discussed by leading thinkers and researchers in biogerontology and cytogerontology. This collection of articles provides state-of-the-art information, and will encourage students, teachers, health care professionals and others interested in the biology of ageing to explore the fascinating and challenging question of why and how our cells age, and what can and cannot be done about it.

Table of contents (17 chapters)

  • Origins of the Hayflick System, the Phenomenon and the Limit

    Rattan, Suresh I. S.

    Pages 3-14

    Preview Buy Chapter 30,19 €
  • Experimental Foundations of the Hayflick System

    Rattan, Suresh I. S.

    Pages 15-26

    Preview Buy Chapter 30,19 €
  • Slowing Down of the Cell Cycle During Fibroblast Proliferation

    Macieira-Coelho, Alvaro

    Pages 29-47

    Preview Buy Chapter 30,19 €
  • Influence of Donor Age and Species Longevity on Replicative Cellular Senescence

    Lorenzini, Antonello (et al.)

    Pages 49-70

    Preview Buy Chapter 30,19 €
  • Ageing of the Stem Cells: The Conjoined Twosome Growing Old: Stem Cell and Its Niche

    Lepperdinger, Günter

    Pages 71-83

    Preview Buy Chapter 30,19 €

Buy this book

eBook 118,99 €
price for Spain (gross)
  • ISBN 978-3-319-26239-0
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover 155,99 €
price for Spain (gross)
  • ISBN 978-3-319-26237-6
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
  • The final prices may differ from the prices shown due to specifics of VAT rules
Softcover 155,99 €
price for Spain (gross)
  • ISBN 978-3-319-79912-4
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
  • The final prices may differ from the prices shown due to specifics of VAT rules
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Bibliographic Information

Bibliographic Information
Book Title
Cellular Ageing and Replicative Senescence
Editors
  • Suresh I.S. Rattan
  • Leonard Hayflick
Series Title
Healthy Ageing and Longevity
Series Volume
4
Copyright
2016
Publisher
Springer International Publishing
Copyright Holder
Springer International Publishing Switzerland
eBook ISBN
978-3-319-26239-0
DOI
10.1007/978-3-319-26239-0
Hardcover ISBN
978-3-319-26237-6
Softcover ISBN
978-3-319-79912-4
Series ISSN
2199-9007
Edition Number
1
Number of Pages
VIII, 364
Number of Illustrations
9 b/w illustrations, 18 illustrations in colour
Topics