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Cellular Ageing and Replicative Senescence

  • Book
  • © 2016

Overview

Editors:
  1. Suresh I.S. Rattan

    1. Dep of Molecular Biology and Genetics, Aarhus University, Aarhus, Denmark

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  2. Leonard Hayflick

    1. Department of Anatomy,School of Medicine, University of California, San Francisco, USA

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    You can also search for this editor in PubMed   Google Scholar

  • Provides a review of historical development of ideas in cellular ageing and replicative senescence
  • Presents a discussion of ageing and cancer in cell proliferation regulation
  • Explains usage of the cellular ageing model system for testing ageing modulators or anti-ageing compounds
  • Offers practical suggestions for future research and development in human health and disease
  • Includes supplementary material: sn.pub/extras

Part of the book series: Healthy Ageing and Longevity (HAL)

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Table of contents (17 chapters)

  1. Front Matter

    Pages i-viii
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  2. History and Origins

    1. Front Matter

      Pages 1-1
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    2. Origins of the Hayflick System, the Phenomenon and the Limit

      • Suresh I. S. Rattan
      Pages 3-14

    3. Experimental Foundations of the Hayflick System

      • Suresh I. S. Rattan
      Pages 15-26

  3. Serial Passaging and Progressive Changes

    1. Front Matter

      Pages 27-27
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    2. Slowing Down of the Cell Cycle During Fibroblast Proliferation

      • Alvaro Macieira-Coelho
      Pages 29-47

    3. Influence of Donor Age and Species Longevity on Replicative Cellular Senescence

      • Antonello Lorenzini, Andrea B. Maier
      Pages 49-70

    4. Ageing of the Stem Cells: The Conjoined Twosome Growing Old: Stem Cell and Its Niche

      • Günter Lepperdinger
      Pages 71-83

    5. Ageing and Senescence in Immune Cells In Vitro and In Vivo

      • Graham Pawelec, Yvonne Barnett
      Pages 85-95

    6. Telomeres Shortening: A Mere Replicometer?

      • Stella Victorelli, João F. Passos
      Pages 97-115

    7. Modeling Cellular Aging: An Introduction – Mathematical and Computational Approaches

      • Tarynn M. Witten
      Pages 117-141

  4. Ageing, Cancer and Senescence

    1. Front Matter

      Pages 143-143
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    2. Cell Cycle Checkpoints and Senescence

      • Renu Wadhwa, Zeenia Kaul, Sunil C. Kaul
      Pages 145-167

    3. Mitochondrial Reactive Oxygen Species in Cellular Senescence

      • Timothy Nacarelli, Claudio Torres, Christian Sell
      Pages 169-185

    4. Cellular Aging and Tumor Regulation

      • Andreas Simm, Barbara Seliger, Lars-Oliver Klotz
      Pages 187-201

    5. Biomarkers of Replicative Senescence Revisited

      • Jan O. Nehlin
      Pages 203-239

  5. Ageing Modulators

    1. Front Matter

      Pages 241-241
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    2. Stress-Induced (Premature) Senescence

      • Florence Debacq-Chainiaux, Randa Ben Ameur, Emilie Bauwens, Elise Dumortier, Marie Toutfaire, Olivier Toussaint
      Pages 243-262

    3. Implications of Cellular Senescence on Aging and Disease in the Brain

      • Elizabeth P. Crowe, S. Ferit Tuzer, Justin Cohen, Emre C. Yetkin, Luca D’Agostino, Christian Sell et al.
      Pages 263-286

    4. Small Noncoding RNAs in Senescence and Aging

      • Joseph M. Dhahbi
      Pages 287-312
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Keywords

About this book

This book covers the origins and subsequent history of research results in which attempts have been made to clarify issues related to cellular ageing, senescence, and age-related pathologies including cancer. Cellular Ageing and Replicative Senescence revisits more than fifty-five years of research based on the discovery that cultured normal cells are mortal and the interpretation that this phenomenon is associated with the origins of ageing. The mortality of normal cells and the immortality of cancer cells were also reported to have in vivo counterparts. Thus began the field of cytogerontology.

Cellular Ageing and Replicative Senescence is organized into five sections: history and origins; serial passaging and progressive ageing; cell cycle arrest and senescence; system modulation; and recapitulation and future expectations. These issues are discussed by leading thinkers and researchers in biogerontology and cytogerontology. This collection of articles provides state-of-the-art information, and will encourage students, teachers, health care professionals and others interested in the biology of ageing to explore the fascinating and challenging question of why and how our cells age, and what can and cannot be done about it.


Editors and Affiliations

  • Dep of Molecular Biology and Genetics, Aarhus University, Aarhus, Denmark

    Suresh I.S. Rattan

  • Department of Anatomy,School of Medicine, University of California, San Francisco, USA

    Leonard Hayflick

Bibliographic Information

  • Book Title: Cellular Ageing and Replicative Senescence

  • Editors: Suresh I.S. Rattan, Leonard Hayflick

  • Series Title: Healthy Ageing and Longevity

  • DOI: https://doi.org/10.1007/978-3-319-26239-0

  • Publisher: Springer Cham

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Switzerland AG 2016

  • Hardcover ISBN: 978-3-319-26237-6Published: 17 May 2016

  • Softcover ISBN: 978-3-319-79912-4Published: 26 May 2018

  • eBook ISBN: 978-3-319-26239-0Published: 09 May 2016

  • Series ISSN: 2199-9007

  • Series E-ISSN: 2199-9015

  • Edition Number: 1

  • Number of Pages: VIII, 364

  • Number of Illustrations: 9 b/w illustrations, 18 illustrations in colour

  • Topics: Cytogenetics, Cell Biology, Geriatrics/Gerontology

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