Oral Infections and General Health

1. Front Matter

   Pages i-x

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2. Background Topics

   1. Front Matter

      Pages 1-1

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   2. Introduction

      • Anne Marie Lynge Pedersen

      Pages 3-5

3. Oral Infections and General Health

   1. Front Matter

      Pages 7-7

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   2. Dental Caries and General Health in Children and Adults

      • Svante Twetman

      Pages 9-17

   3. Plausible Mechanisms Explaining the Association of Periodontitis with Cardiovascular Diseases

      • Bruno G. Loos, Wijnand J. Teeuw, Elena A. Nicu

      Pages 19-33

   4. Linkage Between Periodontal Disease and Diabetes Mellitus

      • Palle Holmstrup, Allan Flyvbjerg

      Pages 35-44

   5. Linkage Between Periodontal Disease and Rheumatoid Arthritis

      • Palle Holmstrup, Claus H. Nielsen

      Pages 45-51

   6. Association Between Dental Infections and Renal and Liver Diseases

      • Jukka H. Meurman

      Pages 53-57

   7. Association Between Oral Infections and Cancer Risk

      • Jukka H. Meurman

      Pages 59-64

   8. Oral Candidiasis and the Medically Compromised Patient

      • Camilla Kragelund, Jesper Reibel, Anne Marie Lynge Pedersen

      Pages 65-77

   9. Association Between Oral Infections and Salivary Gland Hypofunction

      • Siri Beier Jensen, Anne Marie Lynge Pedersen

      Pages 79-94

4. Future Diagnostic Methods and Techniques

   1. Front Matter

      Pages 95-95

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   2. The Oral Microbiome in Health and Disease

      • Ingar Olsen

      Pages 97-114

   3. Salivary Microbiota in Oral Health and Disease

      • Daniel Belstrøm

      Pages 115-122

5. Future Perspectives in Management of Oral Infections

   1. Front Matter

      Pages 123-123

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   2. Use of Probiotics in Future Prevention and Treatment of Oral Infections

      • Mette Rose Jørgensen, Mette Kirstine Keller

      Pages 125-136

   3. Management of Patients with Oral Candidiasis

      • Camilla Kragelund, Jesper Reibel, Anne Marie Lynge Pedersen

      Pages 137-144

6. Back Matter

   Pages 145-149

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​This book provides a wide-ranging update on the associations between oral infections and general health. Detailed consideration is given to the underlying mechanisms or pathways linking oral infections to general health, including metastatic spread of infection from the oral cavity as a result of transient bacteremia, metastatic injury from the effects of circulating oral microbial toxins, and metastatic inflammation caused by immunological dysfunction induced by oral microorganisms. The book also reviews the complex structure and development of oral biofilms in health and disease, and the molecular tools that are currently available for their analysis. The advantages and limitations of such techniques, as well as their impact on the future of diagnostics, prevention and patient management, are discussed.

• Cancer risk
• Cardiovascular disease
• Diabetes
• Inflammation
• Oral microbiome
• Periodontitis

• Department of Odontology, University of Copenhagen, Copenhagen, Denmark

  Anne Marie Lynge Pedersen

Anne Marie Lynge Pedersen, DDS, PhD, is Associate Professor and Head of the Department of Odontology/Dental Dean in the Faculty of Health and Medical Sciences, University of Copenhagen, Denmark. Dr. Pedersen graduated in 1992 from the Royal Dental College, Copenhagen, Denmark, and gained her PhD from the University of Copenhagen in 1997 for a thesis entitled Salivary gland dysfunction in patients with primary Sjögren’s syndrome. She then joined the Section of Oral Physiology and Oral Pathology & Medicine, Department of Odontology, University of Copenhagen, as a research assistant, and progressed to become head of the department in 2013. From 2009 to 2012 Dr. Pedersen was Vice President and board member of the Scandinavian Division of the International Association of Dental Research (IADR), and she became President of the Division in January 2013. She has also served as an appointed board member of the Danish Dental Association Research Foundation (2007-2013) and acts as a consultant to the Danish Dental Association on topics such as xerostomia, salivary gland function, oral mucosal diseases, and pharmacology. Dr. Pedersen has been the organizer of national and international conferences, seminars, and symposia and is a referee for many leading international scientific journals. She is the author of more than 80 national and international scientific papers and book chapters.

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