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Organic Cation Transporters

Integration of Physiology, Pathology, and Pharmacology

Editors: Ciarimboli, Giuliano, Gautron, Sophie, Schlatter, Eberhard (Eds.)

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  • ​Conjugates integrative transporter physiology, with structural and molecular biology, genetics, pharmacology and pathophysiology, offering an integration of the knowledge in these fields
  • Provides important information on the involvement of transporters for organic cations in determining specific effects but also side effects induced by particular drugs, offering new approaches for a successful translation from physiology to clinical therapy
  • Discusses the role of transporters for organic cations in plants for the environmental cycling of pharmaceutical residues
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eBook 117,69 €
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  • ISBN 978-3-319-23793-0
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Hardcover 155,99 €
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  • ISBN 978-3-319-23792-3
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  • Immediate ebook access, if available*, with your print order
  • Usually ready to be dispatched within 3 to 5 business days.
  • The final prices may differ from the prices shown due to specifics of VAT rules
Softcover 155,99 €
price for Spain (gross)
  • ISBN 978-3-319-79534-8
  • Free shipping for individuals worldwide
  • Immediate ebook access, if available*, with your print order
  • Usually ready to be dispatched within 3 to 5 business days.
  • The final prices may differ from the prices shown due to specifics of VAT rules
About this book

This innovative text explores the cellular transport of organic cations, from functional and structural properties to pharmacological implications and psychiatric developments. The authoritative chapters introduce organic cation transporters and then proceed to discuss their mechanisms such as binding of substrates and inhibitors; their drug dispositions and toxicity; their relationships to genetic and pathophysiological variability; and their roles in endocrine, metabolic, and neurological systems. The final chapters delve into the use of animal models for the study of organic cation transporter function and their possible use in environmental cycling of pharmaceutical residues.

This comprehensive volume unites integrative transporter physiology with structural and molecular biology, genetics, pharmacology and pathophysiology, offering a holistic approach to utilizing this novel technique in physiological contexts. It will prove invaluable reading for researchers and students in various areas of integrative, organ, cell and molecular physiology as well as pharmacologists and neurologists.

Reviews

“This encyclopedic resource provides extensively detailed, state-of-the-art information about cellular organic cation transporters and their relevance to human function and disease. … This is a magnificent resource for scientists actively engaged in any research related to the biology of organic ion transporters. Every conceivable topic related to these transporters is addressed, making it useful for active researchers in a wide variety of biomedical and biological disciplines.” (David R. Bell, Doody’s Book Reviews, April, 2016)


Table of contents (10 chapters)

Table of contents (10 chapters)
  • Introduction to the Cellular Transport of Organic Cations

    Pages 1-47

    Ciarimboli, Giuliano

  • Functional Properties of Organic Cation Transporter OCT1, Binding of Substrates and Inhibitors, and Presumed Transport Mechanism

    Pages 49-72

    Koepsell, Hermann (et al.)

  • Pharmacological and Toxicological Significance of the Organic Cation Transporters OCT and MATE: Drug Disposition, Interaction and Toxicity

    Pages 73-92

    Motohashi, Hideyuki, Ph.D. (et al.)

  • Genetic Variability in Organic Cation Transporters: Pathophysiological Manifestations and Consequences for Drug Pharmacokinetics and Efficacy

    Pages 93-137

    Tzvetkov, Mladen Vassilev (et al.)

  • Physiological and Pathophysiological Regulation of Transporters for Organic Cations

    Pages 139-169

    Schlatter, Eberhard

Buy this book

eBook 117,69 €
price for Spain (gross)
  • ISBN 978-3-319-23793-0
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover 155,99 €
price for Spain (gross)
  • ISBN 978-3-319-23792-3
  • Free shipping for individuals worldwide
  • Immediate ebook access, if available*, with your print order
  • Usually ready to be dispatched within 3 to 5 business days.
  • The final prices may differ from the prices shown due to specifics of VAT rules
Softcover 155,99 €
price for Spain (gross)
  • ISBN 978-3-319-79534-8
  • Free shipping for individuals worldwide
  • Immediate ebook access, if available*, with your print order
  • Usually ready to be dispatched within 3 to 5 business days.
  • The final prices may differ from the prices shown due to specifics of VAT rules
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Bibliographic Information

Bibliographic Information
Book Title
Organic Cation Transporters
Book Subtitle
Integration of Physiology, Pathology, and Pharmacology
Editors
  • Giuliano Ciarimboli
  • Sophie Gautron
  • Eberhard Schlatter
Copyright
2016
Publisher
Springer International Publishing
Copyright Holder
Springer International Publishing Switzerland
eBook ISBN
978-3-319-23793-0
DOI
10.1007/978-3-319-23793-0
Hardcover ISBN
978-3-319-23792-3
Softcover ISBN
978-3-319-79534-8
Edition Number
1
Number of Pages
XV, 264
Number of Illustrations
20 b/w illustrations, 14 illustrations in colour
Topics

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