Editors:
- Provides state-of-the-art reviews on host-pathogen interactions
- Offers comprehensive information on the immunological processes involved in pathogen defense in different organisms
- Written by international experts from different fields
- Includes supplementary material: sn.pub/extras
Part of the book series: Results and Problems in Cell Differentiation (RESULTS, volume 57)
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Table of contents (13 chapters)
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Front Matter
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Pathogens: Antigen Repertoires and Variations
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Front Matter
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Hosts: Anticipatory and Adapting Mechanisms
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Front Matter
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Back Matter
About this book
This volume provides in-depth reviews of model systems that exemplify the arms race in host-pathogen interactions. Somatic adaptations are responsible for the individualization of biological responses to the environment, and the continual struggle between host immune systems and invading pathogens has given rise to corresponding processes that produce molecular variation. Whether in mollusks or human beings, various host somatic mechanisms have evolved independently, providing responses to counter rapidly-changing pathogens. The pathways they utilize can include non-heritable changes involving RNA and post-translational modifications, or changes that produce somatic DNA recombination and mutation. For infectious organisms such as protozoans and flatworms, antigenic variation is central to their survival strategy. Evolving the ability to evade the host immune system not only increases their chances of survival but is also necessary for successful re-infection within the host population.
Editors and Affiliations
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Department of Physiology and Pharmacology, SUNY Downstate Medical Center, Brooklyn, USA
Ellen Hsu
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Institute of Zoology and Evolutionary Biology, University of Basel, Basel, Switzerland
Louis Du Pasquier
Bibliographic Information
Book Title: Pathogen-Host Interactions: Antigenic Variation v. Somatic Adaptations
Editors: Ellen Hsu, Louis Du Pasquier
Series Title: Results and Problems in Cell Differentiation
DOI: https://doi.org/10.1007/978-3-319-20819-0
Publisher: Springer Cham
eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)
Copyright Information: Springer International Publishing Switzerland 2015
Hardcover ISBN: 978-3-319-20818-3Published: 13 November 2015
Softcover ISBN: 978-3-319-37182-5Published: 23 August 2016
eBook ISBN: 978-3-319-20819-0Published: 04 November 2015
Series ISSN: 0080-1844
Series E-ISSN: 1861-0412
Edition Number: 1
Number of Pages: VIII, 336
Topics: Immunology, Evolutionary Biology, Cell Biology, Parasitology