Advances in Experimental Medicine and Biology

Lipids in Protein Misfolding

Editors: Gursky, Olga (Ed.)

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  • Explains how protein misfolding is an important biological phenomenon underlying over 20 major human diseases
  • Shows that Lipids importantly influence protein misfolding and amyloid diseases
  • Provides an up-to-date analysis of the roles of lipids in protein misfolding
  • Discusses a wide array of proteins, lipids and their modes of interaction
  • Focusses on the biophysical and structural properties of the interacting partners
  • Complements the small collection of books on this topic in this rapidly developing field
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eBook 117,69 €
price for Spain (gross)
  • ISBN 978-3-319-17344-3
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • Immediate eBook download after purchase and usable on all devices
  • Bulk discounts from 10 eBooks
Hardcover 166,39 €
price for Spain (gross)
Softcover 145,78 €
price for Spain (gross)
About this book

​Protein conversion from a water-soluble native conformation to the insoluble aggregates and fibrils, which can deposit in amyloid plaques, underlies more than 20 human diseases, representing a major public health problem and a scientific challenge. Such a conversion is called protein misfolding. Protein misfolding can also involve errors in the topology of the folded proteins and their assembly in lipid membranes. Lipids are found in nearly all amyloid deposits in vivo, and can critically influence  protein misfolding in vitro and in vivo in many different ways. This book focuses on recent advances in our understanding of the role of lipids in modulating the misfolding of various proteins. The main emphasis is on the basic biophysical studies that address molecular basis of protein misfolding and amyloid formation, and the role of lipids in this complex process.

Table of contents (10 chapters)

Table of contents (10 chapters)
  • Role of Lipids in Folding, Misfolding and Function of Integral Membrane Proteins

    Pages 1-31

    Hong, Heedeok

  • Protein Misfolding in Lipid-Mimetic Environments

    Pages 33-66

    Uversky, Vladimir N.

  • Lipids in Amyloid-β Processing, Aggregation, and Toxicity

    Pages 67-94

    Morgado, Isabel (et al.)

  • Role of Cholesterol and Phospholipids in Amylin Misfolding, Aggregation and Etiology of Islet Amyloidosis

    Pages 95-116

    Singh, Sanghamitra (et al.)

  • Intrinsic Stability, Oligomerization, and Amyloidogenicity of HDL-Free Serum Amyloid A

    Pages 117-134

    Colón, Wilfredo (et al.)

Buy this book

eBook 117,69 €
price for Spain (gross)
  • ISBN 978-3-319-17344-3
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • Immediate eBook download after purchase and usable on all devices
  • Bulk discounts from 10 eBooks
Hardcover 166,39 €
price for Spain (gross)
Softcover 145,78 €
price for Spain (gross)
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Bibliographic Information

Bibliographic Information
Book Title
Lipids in Protein Misfolding
Editors
  • Olga Gursky
Series Title
Advances in Experimental Medicine and Biology
Series Volume
855
Copyright
2015
Publisher
Springer International Publishing
Copyright Holder
Springer International Publishing Switzerland
eBook ISBN
978-3-319-17344-3
DOI
10.1007/978-3-319-17344-3
Hardcover ISBN
978-3-319-17343-6
Softcover ISBN
978-3-319-37205-1
Series ISSN
0065-2598
Edition Number
1
Number of Pages
XIII, 260
Number of Illustrations
26 b/w illustrations, 57 illustrations in colour
Topics