Epilepsy Towards the Next Decade

1. Front Matter

   Pages i-x

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2. Copy Number Variants and Epilepsy: New Emerging Syndromes

   • Antonietta Coppola, Maurizio Elia

   Pages 1-14

3. Mutations of Ion Channels in Genetic Epilepsies

   • Massimo Mantegazza, Raffaella Rusconi, Sandrine Cestèle

   Pages 15-34

4. LGI1 Dysfunction in Inherited and Acquired Epileptic Disorders

   • Carlo Nobile

   Pages 35-45

5. Glioneuronal Tumors and Epilepsy: Clinico-Diagnostic Features and Surgical Strategies

   • Alessandro Consales, Paolo Nozza, Maria Luisa Zoli, Giovanni Morana, Armando Cama

   Pages 47-70

6. Metabolic Causes of Epilepsy

   • Laura Papetti, Francesco Nicita, Stella Maiolo, Vincenzo Leuzzi, Alberto Spalice

   Pages 71-99

7. New Insights into Mechanisms Underlying Generalized Reflex Seizures

   • Edoardo Ferlazzo, Domenico Italiano, Sara Gasparini, Giovanbattista Gaspare Tripodi, Tiziana D’Agostino, Umberto Aguglia

   Pages 101-107

8. Current Status and Future Prospective of Neuroimaging for Epilepsy

   • F. Caranci, F. D’Arco, A. D’Amico, C. Russo, F. Briganti, M. Quarantelli et al.

   Pages 109-137

9. The Complex Relationship Between Epilepsy and Headache and the Concept of Ictal Epileptic Headache

   • Pasquale Parisi

   Pages 139-162

10. Epilepsy and Immune System: A Tour Around the Current Literature

    • Laura Mumoli, Angelo Labate, Antonietta Coppola, Giovambattista De Sarro, Emilio Russo, Antonio Gambardella

    Pages 163-182

11. Novel Molecular Targets for Drug-Treatment of Epilepsy

    • Vincenzo Belcastro, Alberto Verrotti

    Pages 183-199

12. Reproductive Hormones in Epilepsy Therapy: From Old Promises to New Hopes

    • Alberto Verrotti, Giovanni Prezioso, Claudia D’Egidio, Vincenzo Belcastro

    Pages 201-211

13. Neuromodulation for the Treatment of Drug-Resistant Epilepsy

    • Pantaleo Romanelli, Alfredo Conti

    Pages 213-230

14. New Radiosurgical Paradigms to Treat Epilepsy Using Synchrotron Radiation

    • Pantaleo Romanelli, Alberto Bravin, Erminia Fardone, Giuseppe Battaglia

    Pages 231-236

15. Back Matter

    Pages 237-238

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A comprehensive collection of the most recent knowledge on the biological bases of various kinds of epilepsies and modern clinical approaches to their treatment. Epilepsy affects about 0.5-1% of the world's population (about 50,000,000 individuals) and the main goal of its treatment is to eliminate seizures without creating side effects. Despite numerous advances in the treatment of epilepsy and the approval of several new antiepileptic drugs, about 30% of patients continue to experience recurrent seizures which are medically, physically, and/or socially disabling. The editor of this volume hopes that by bridging the gap between the fundamental biology of epilepsy and its clinical implications he might spur further research and treatment options.​

• biology
• classification
• diagnosis
• epilepsy
• etiology
• treatment

• DINOGMI, University of Genoa, Genova, Italy

  Pasquale Striano

Dr. Pasquale Striano is a Research Associate at the University of Genova's Pediatric Neurology and Muscular Diseases Unit, where his main field of interest is molecular genetics of idiopathic epilepsies with a special interest in structural genomic variation and genotype-phenotype relationships. Dr. Striano is actively included in multicenter projects in Italy, Europe, and around the world. He is also a member of the Board of Italian League Against Epilepsy (LICE), a scientific association focused on promoting knowledge of Epilepsy in order to improve patient care.

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