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Cytochrome P450

Structure, Mechanism, and Biochemistry

Editors: Ortiz de Montellano, Paul R. (Ed.)

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  • Two-volume Fourth Edition updated with the most cutting-edge research
  • Explores the advances of the past decade on the structure, mechanism, and biochemistry of cytochrome P450 enzymes
  • Discusses structure and role of cytochrome P450 in biology
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eBook 181,89 €
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  • ISBN 978-3-319-12108-6
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Hardcover 311,99 €
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  • ISBN 978-3-319-12107-9
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  • Immediate ebook access, if available*, with your print order
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Softcover 227,76 €
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  • ISBN 978-3-319-37437-6
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  • Immediate ebook access, if available*, with your print order
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About this Textbook

This authoritative Fourth Edition summarizes the advances of the past decade concerning the structure, mechanism, and biochemistry of cytochrome P450 enzymes, with sufficient coverage of earlier work to make each chapter a comprehensive review of the field. Thirteen chapters are divided into two detailed volumes, the first covering the fundamentals of cytochrome P450 biochemistry, as well as the microbial, plant, and insect systems, and the second exclusively focusing on mammalian systems.

Volume 1 begins with an exploration of the biophysics and mechanistic enzymology of cytochrome P450 enzymes, with a discussion of the structures of P450 enzymes and their electron donor partners, the mechanisms of oxygen activation and substrate oxidation, and the approaches and nature of cytochrome P450 inhibition. Two more chapters discuss the nature and roles of cytochrome P450 enzymes in microbes, plants and insects, and an eighth chapter is a survey of the potential utility of P450 enzymes in biotechnology. The first chapter of Volume 2 examines the roles of P450 enzymes in mammals, mainly humans. Four further chapters then deal with the genetic and hormonal regulation of P450 enzymes and their specific roles in the processing of sterols and lipids. Cytochrome P450: Structure, Mechanism, and Biochemistry is a key resource for scientists, professors, and students interested in fields as diverse as biochemistry, chemistry, biophysics, molecular biology, pharmacology and toxicology.

About the authors

Paul R. Ortiz de Montellano received his PhD in bioorganic chemistry from Harvard University, Cambridge, MA. After postdoctoral work as a North Atlantic Treaty Organization Fellow in Zürich, Switzerland, and a stint with Syntex in Mexico City and Palo Alto, California, he joined the faculty of the University of California in San Francisco, where he is currently Professor, Vice-chair of the Department of Pharmaceutical Chemistry, and Associate Dean for Research of the School of Pharmacy. His research interests center on the structure, mechanism, inhibition, and biochemistry of hemoproteins, including the cytochrome P450 enzymes. He has received the B.B. Brodie Award in Drug Metabolism from the American Society of Pharmacology and Experimental Therapeutics, the R.T. Williams Distinguished Scientific Achievement Award from the International Society for the Study of Xenobiotics, and the Ernest H. Volwiler Research Achievement Award from the American Association of Colleges of Pharmacy.

Table of contents (13 chapters)

Table of contents (13 chapters)

Buy this book

eBook 181,89 €
price for Spain (gross)
  • ISBN 978-3-319-12108-6
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover 311,99 €
price for Spain (gross)
  • ISBN 978-3-319-12107-9
  • Free shipping for individuals worldwide
  • Immediate ebook access, if available*, with your print order
  • Usually dispatched within 3 to 5 business days.
  • The final prices may differ from the prices shown due to specifics of VAT rules
Softcover 227,76 €
price for Spain (gross)
  • ISBN 978-3-319-37437-6
  • Free shipping for individuals worldwide
  • Immediate ebook access, if available*, with your print order
  • Usually dispatched within 3 to 5 business days.
  • The final prices may differ from the prices shown due to specifics of VAT rules
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Bibliographic Information

Bibliographic Information
Book Title
Cytochrome P450
Book Subtitle
Structure, Mechanism, and Biochemistry
Editors
  • Paul R. Ortiz de Montellano
Copyright
2015
Publisher
Springer International Publishing
Copyright Holder
Springer International Publishing Switzerland
eBook ISBN
978-3-319-12108-6
DOI
10.1007/978-3-319-12108-6
Hardcover ISBN
978-3-319-12107-9
Softcover ISBN
978-3-319-37437-6
Edition Number
4
Number of Pages
X, 912
Number of Illustrations
163 b/w illustrations, 80 illustrations in colour
Topics

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