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  • © 2015

The Networking of Chaperones by Co-chaperones

Control of Cellular Protein Homeostasis

  • This is the only book that specifically reviews the knowledge on co-chaperones as opposed to chaperones
  • Excellent information resource for researchers entering the specialized field of cell stress and chaperones
  • Excellent information resource for researchers in the broader field of diseases related to protein folding (e.g. Alzheimers)
  • Includes supplementary material: sn.pub/extras

Part of the book series: Subcellular Biochemistry (SCBI, volume 78)

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Table of contents (12 chapters)

  1. Front Matter

    Pages i-xv
  2. Functions of the Hsp90-Binding FKBP Immunophilins

    • Naihsuan C. Guy, Yenni A. Garcia, Jeffrey C. Sivils, Mario D. Galigniana, Marc B. Cox
    Pages 35-68
  3. Hsp70/Hsp90 Organising Protein (Hop): Beyond Interactions with Chaperones and Prion Proteins

    • Swati Baindur-Hudson, Adrienne L. Edkins, Gregory L. Blatch
    Pages 69-90
  4. Specification of Hsp70 Function by Type I and Type II Hsp40

    • Douglas M. Cyr, Carlos H. Ramos
    Pages 91-102
  5. Cdc37 as a Co-chaperone to Hsp90

    • Stuart K. Calderwood
    Pages 103-112
  6. p23 and Aha1

    • Alexandra Beatrice Rehn, Johannes Buchner
    Pages 113-131
  7. UCS Proteins: Chaperones for Myosin and Co-Chaperones for Hsp90

    • Weiming Ni, Odutayo O. Odunuga
    Pages 133-152
  8. Chaperonin—Co-chaperonin Interactions

    • Aileen Boshoff
    Pages 153-178
  9. Co-chaperones of the Mammalian Endoplasmic Reticulum

    • Armin Melnyk, Heiko Rieger, Richard Zimmermann
    Pages 179-200
  10. The Evolution and Function of Co-Chaperones in Mitochondria

    • Neta Regev-Rudzki, Kip Gabriel, Dejan Bursać
    Pages 201-217
  11. The Role of HSP70 and Its Co-chaperones in Protein Misfolding, Aggregation and Disease

    • Emma J. Duncan, Michael E. Cheetham, J. Paul Chapple, Jacqueline van der Spuy
    Pages 243-273
  12. Back Matter

    Pages 275-276

About this book

Co-chaperones are important mediators of the outcome of chaperone assisted protein homeostasis, which is a dynamic balance between the integrated processes of protein folding, degradation and translocation. The Networking of Chaperones by Co-chaperones describes how the function of the major molecular chaperones is regulated by a cohort of diverse non-client proteins, known as co-chaperones. The second edition includes the current status of the field and descriptions of a number of novel co-chaperones that have been recently identified. This new edition has a strong focus on the role of co-chaperones in human disease and as putative drug targets. The book will be a resource for both newcomers and established researchers in the field of cell stress and chaperones, as well as those interested in cross-cutting disciplines such as cellular networks and systems biology.

Editors and Affiliations

  • Victoria University, College of Health and Biomedicine, Melbourne, Australia

    Gregory Lloyd Blatch

  • Department of Biochemistry and Microbiology, Rhodes University, Biomedical Biotechnology Research Unit, Grahamstown, South Africa

    Adrienne Lesley Edkins

Bibliographic Information

  • Book Title: The Networking of Chaperones by Co-chaperones

  • Book Subtitle: Control of Cellular Protein Homeostasis

  • Editors: Gregory Lloyd Blatch, Adrienne Lesley Edkins

  • Series Title: Subcellular Biochemistry

  • DOI: https://doi.org/10.1007/978-3-319-11731-7

  • Publisher: Springer Cham

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: Springer International Publishing Switzerland 2015

  • Hardcover ISBN: 978-3-319-11730-0Published: 12 January 2015

  • Softcover ISBN: 978-3-319-38149-7Published: 24 September 2016

  • eBook ISBN: 978-3-319-11731-7Published: 08 December 2014

  • Series ISSN: 0306-0225

  • Series E-ISSN: 2542-8810

  • Edition Number: 1

  • Number of Pages: XV, 276

  • Number of Illustrations: 4 b/w illustrations, 31 illustrations in colour

  • Topics: Biomedicine general, Life Sciences, general, Biochemistry, general

Buy it now

Buying options

eBook USD 129.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Hardcover Book USD 169.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Other ways to access