Clinical Pharmacokinetic and Pharmacodynamic Drug Interactions Associated with Antimalarials

Authors: Kiang, Tony K. L., Wilby, Kyle John, Ensom, Mary H.H.

  • Discusses the clinical pharmacokinetic and pharmacodynamic drug interactions involving antimalarial drugs recommended by the WHO
  • Addresses the clinical significance of the interactions and provides a clinical decision making algorithm
  • Covers potential mechanisms of the identified drug interactions using known pre-clinical human data
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eBook 51,16 €
price for Spain (gross)
  • ISBN 978-3-319-10527-7
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover 67,59 €
price for Spain (gross)
  • ISBN 978-3-319-10526-0
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
  • The final prices may differ from the prices shown due to specifics of VAT rules
Softcover 62,39 €
price for Spain (gross)
  • ISBN 978-3-319-38193-0
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
  • The final prices may differ from the prices shown due to specifics of VAT rules
About this book

This comprehensive review provides a systematic, unbiased analysis, critique and summary of the available literature and generates novel clinical decision-making algorithms which can aid clinicians and scientists in practice management and research development. Potential mechanisms for the identified drug interactions are deduced from available preclinical and in vitro data which are interpreted in the context of the in vivo findings. Current limitations and gaps in the literature are summarized, and potential future research directions / experimentations are also suggested.  In addition to the main objective to review the available clinical pharmacokinetic and pharmacodynamic drug interactions associated with WHO-recommended antimalarial drugs on the market today (i.e. chloroquine, amodiaquine, sulfadoxine, pyrimethamine, mefloquine, artemisinin, artemether, artesunate, dihydroartemisinin, artemotil, lumefantrine, primaquine, atovaquone, proguanil, piperaquine and quinine), this book also provides succinct chapter summaries on the epidemiology of malaria infection, diagnosis and therapeutics, in vivo pharmacology and chemistry, preclinical pharmacology, in vitro pharmacodynamics, in vitro reaction phenotyping, and in vitro drug-drug interaction data associated with the identified antimalarial drugs.

Table of contents (8 chapters)

  • Introduction

    Kiang, Tony K. L. (et al.)

    Pages 1-7

    Preview Buy Chapter 30,19 €
  • Pharmacology of Recommended Antimalarial Agents

    Kiang, Tony K. L. (et al.)

    Pages 9-16

    Preview Buy Chapter 30,19 €
  • Drug Interaction Potential of Antimalarial Drugs Based on Known Metabolic Properties of Antimalarials

    Kiang, Tony K. L. (et al.)

    Pages 17-25

    Preview Buy Chapter 30,19 €
  • Pharmacokinetic Drug Interactions Affecting Antimalarials

    Kiang, Tony K. L. (et al.)

    Pages 27-55

    Preview Buy Chapter 30,19 €
  • Effects of Antimalarials on the Pharmacokinetics of Co-Administered Drugs

    Kiang, Tony K. L. (et al.)

    Pages 57-85

    Preview Buy Chapter 30,19 €

Buy this book

eBook 51,16 €
price for Spain (gross)
  • ISBN 978-3-319-10527-7
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover 67,59 €
price for Spain (gross)
  • ISBN 978-3-319-10526-0
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
  • The final prices may differ from the prices shown due to specifics of VAT rules
Softcover 62,39 €
price for Spain (gross)
  • ISBN 978-3-319-38193-0
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
  • The final prices may differ from the prices shown due to specifics of VAT rules
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Bibliographic Information

Bibliographic Information
Book Title
Clinical Pharmacokinetic and Pharmacodynamic Drug Interactions Associated with Antimalarials
Authors
Copyright
2015
Publisher
ADIS
Copyright Holder
Springer International Publishing Switzerland
eBook ISBN
978-3-319-10527-7
DOI
10.1007/978-3-319-10527-7
Hardcover ISBN
978-3-319-10526-0
Softcover ISBN
978-3-319-38193-0
Edition Number
1
Number of Pages
VII, 146
Number of Illustrations and Tables
1 illustrations in colour
Topics