The Mechanobiology of Obesity and Related Diseases
Editors: Gefen, Amit, Benayahu, Dafna (Eds.)
Free Preview- Describes the state-of-knowledge in the study of the relationships between mechanical loading states in tissues and common pathophysiologies
- Includes the important topics at the frontier of this field
- Written by important scientists in the field
Buy this book
- About this book
-
This volume describes the state-of-knowledge in the study of the relationships between mechanical loading states in tissues and common pathophysiologies related to increase in mass of adipose tissues and/or hyperglycemia which eventually lead to obesity, diabetes, insulin resistance, hyperlipidemia, metabolic inflammations, certain types of cancer and other related diseases.
There appears to be an interaction between the loading states in tissues and cells and these chronic conditions, as well as with factors such as age, gender and genetics of the individual. Bioengineering has made key contributions to this research field in providing technologies for cell biomechanics experimentation, microscopy and image processing, tissue engineering and multi-scale, multi-physics computational modeling. Topics at the frontier of this field of study include: the continuous monitoring of cell growth, proliferation and differentiation in response to mechanical factors such as stiffness of the extracellular matrix (ECM) and mechanical loads transferred through the ECM; mechanically-activated signaling pathways and molecular mechanisms; effects of different loading regimes and mechanical environments on differentiation fates of mesenchymal stem cells (MSCs) into myogenic and osteogenic versus adipogenic lineages; the interactions between nutrition and mechanotransduction; cell morphology, focal adhesion patterns and cytoskeletal remodeling changes in adipogenesis; activation of receptors related to diabetes by mechanical forces; brown and white adipose plasticity and its regulation by mechanical factors.
- Table of contents (12 chapters)
-
-
Mechanical Behavior and Properties of Adipose Tissue
Pages 3-9
-
Mathematical Models of Adipose Tissue Dynamics
Pages 11-34
-
Mechanical Stretching and Signaling Pathways in Adipogenesis
Pages 35-62
-
Role of Mechanical Stimulations in Directing Mesenchymal Stem Cell Adipogenesis
Pages 63-87
-
The Vicious Cycle of Estrogen Consumption and Obesity: The Role of Mechanotransduction
Pages 89-103
-
Table of contents (12 chapters)
- Download Preface 1 PDF (47.5 KB)
- Download Sample pages 2 PDF (865.7 KB)
- Download Table of contents PDF (48.9 KB)
Recommended for you
Bibliographic Information
- Bibliographic Information
-
- Book Title
- The Mechanobiology of Obesity and Related Diseases
- Editors
-
- Amit Gefen
- Dafna Benayahu
- Series Title
- Studies in Mechanobiology, Tissue Engineering and Biomaterials
- Series Volume
- 16
- Copyright
- 2015
- Publisher
- Springer International Publishing
- Copyright Holder
- Springer-Verlag Berlin Heidelberg
- eBook ISBN
- 978-3-319-09336-9
- DOI
- 10.1007/978-3-319-09336-9
- Hardcover ISBN
- 978-3-319-09335-2
- Softcover ISBN
- 978-3-319-37626-4
- Series ISSN
- 1868-2006
- Edition Number
- 1
- Number of Pages
- X, 296
- Topics
