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Structural and Functional Characterization of the Immunoproteasome

  • Book
  • © 2013

Overview

Authors:
  1. Eva Maria Huber

    1. Chair of Biochemistry, Technische Universität München, Garching, Germany

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  • Nominated as an outstanding Ph.D. thesis by the Technische Universität München, Germany
  • Detailed analysis of the X-ray structures of the murine immune- and constitutive proteasome
  • Yeast mutagenesis study to explore the differences between the constitutive proteasome, the immunoproteasome and the thymoproteasome
  • Inhibition studies on the immunoproteasome-selective compound ONX 0914
  • Includes supplementary material: sn.pub/extras

Part of the book series: Springer Theses (Springer Theses)

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Table of contents (5 chapters)

  1. Front Matter

    Pages i-xix
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  2. Introduction

    • Eva Maria Huber
    Pages 1-18

  3. Objective

    • Eva Maria Huber
    Pages 19-19

  4. Materials and Methods

    • Eva Maria Huber
    Pages 21-39

  5. Results

    • Eva Maria Huber
    Pages 41-70

  6. Discussion

    • Eva Maria Huber
    Pages 71-76

  7. Back Matter

    Pages 77-82
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Keywords

About this book

In this acclaimed thesis, Eva Maria Huber reveals ground-breaking results by elucidating the crystal structure of the murine immunoproteasome in complex with a selective inhibitor. Huber does this by performing multidisciplinary methodologies including X-ray crystallography, fluorescence spectroscopy and mutagenesis experiments. Her exceptional results explore the immunoproteasome complex structures and are of outstanding importance for future scientific research especially in the pharmaceutical industry. These results will enable the functional analysis of individual proteasome subunits and support the development of novel drugs for autoimmune diseases such as multiple sclerosis or rheumatoid arthritis.

Authors and Affiliations

  • Chair of Biochemistry, Technische Universität München, Garching, Germany

    Eva Maria Huber

About the author

Eva Huber studied biochemistry at the Technische Universität München (TUM) from 2004 till 2009. For her master studies, which were funded by the Studienstiftung des deutschen Volkes, she received the Jürgen-Manchot Studienpreis from the faculty of chemistry of the TUM. During her postgraduate studies (2009-2013) in the group of Prof. Groll at the TUM she succeeded in the elucidation of the mouse immuno- and constitutive proteasome X-ray structures in their unliganded state and in complex with the immunoproteasome-selective compound ONX 0914. For these results she has been awarded the “Management Engineers Presidential Award” in 2012.

Bibliographic Information

  • Book Title: Structural and Functional Characterization of the Immunoproteasome

  • Authors: Eva Maria Huber

  • Series Title: Springer Theses

  • DOI: https://doi.org/10.1007/978-3-319-01556-9

  • Publisher: Springer Cham

  • eBook Packages: Chemistry and Materials Science, Chemistry and Material Science (R0)

  • Copyright Information: Springer International Publishing Switzerland 2013

  • Hardcover ISBN: 978-3-319-01555-2Published: 01 October 2013

  • Softcover ISBN: 978-3-319-37810-7Published: 23 August 2016

  • eBook ISBN: 978-3-319-01556-9Published: 16 September 2013

  • Series ISSN: 2190-5053

  • Series E-ISSN: 2190-5061

  • Edition Number: 1

  • Number of Pages: XIX, 82

  • Number of Illustrations: 4 b/w illustrations, 29 illustrations in colour

  • Topics: Analytical Chemistry, Protein Science, Medicinal Chemistry

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