Journal of Neural Transmission. Supplementa

Generalized Non-Convulsive Epilepsy: Focus on GABA-B Receptors

Editors: Marescaux, C., Vergnes, M., Bernasconi, R. (Eds.)

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About this book

Generalized non convulsive epilepsy (GNCE), also called absence or petit mal epilepsy, is a disease appearing during childhood. EEG, clinical, pharmacological and genetic characteristics differ from those of convulsive or focal epilepsies. No underlying structural or biochemical abnormality has been identified for generalized absence seizures and the etiology of this disorder is unknown. It is unlikely that the precise pathophysiology of GNCE can be resolved in studies that focus on humans. Therefore a number of animal models reproducing the human disease have been developed. The aim of this supplementum is to characterize such models in rodents. First, recent models are extensively described. These include the genetic model of spontaneous GNCE in Strasbourg's Wistar rats and in tottering mice as well as bilateral spike and wave discharges induced by GHB, PTZ or GABA mimetics. Second, this supplementum will also provide very recent information on putative mechanisms underlying generalized absence seizures. Third, various experimental approaches aimed at investigating the neural substrate of this particular kind of epilepsy are described with various electrophysiological, pharmacological, biochemical, metabolic, ionic and molecular data. This supplementum provides an original multidisciplinary approach to the mechanisms involved in GNCE and demonstrates that rodent models are a promising tool which complements the classical feline penicillin model.

Table of contents (13 chapters)

Table of contents (13 chapters)

Buy this book

eBook 71,68 €
price for Spain (gross)
  • ISBN 978-3-7091-9206-1
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Softcover 90,47 €
price for Spain (gross)
  • ISBN 978-3-211-82340-8
  • Free shipping for individuals worldwide
  • Institutional customers should get in touch with their account manager
  • Shipping restrictions
  • Usually ready to be dispatched within 3 to 5 business days, if in stock
  • The final prices may differ from the prices shown due to specifics of VAT rules
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Bibliographic Information

Bibliographic Information
Book Title
Generalized Non-Convulsive Epilepsy: Focus on GABA-B Receptors
Editors
  • C. Marescaux
  • M. Vergnes
  • R. Bernasconi
Series Title
Journal of Neural Transmission. Supplementa
Series Volume
35
Copyright
1992
Publisher
Springer-Verlag Wien
Copyright Holder
Springer-Verlag Wien
eBook ISBN
978-3-7091-9206-1
DOI
10.1007/978-3-7091-9206-1
Softcover ISBN
978-3-211-82340-8
Series ISSN
0303-6995
Edition Number
1
Number of Pages
VII, 200
Topics