Antidepressants

1. Front Matter

   Pages I-X

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2. Clinical issues

   1. Front Matter

      Pages 1-1

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   2. Long-term course, comorbidity and long-term outcome in depressive disorders

      • Kerstin Bingefors, Lisa Ekselius, Lars von Knorring

      Pages 3-19

   3. Do antidepressants really take several weeks to show effect?

      • Jules Angst, Hans H. Stassen

      Pages 21-30

   4. Commentary on the limitation of antidepressants in current use

      • Stephen M. Stahl

      Pages 31-43

3. Mechanisms of action

   1. Front Matter

      Pages 45-45

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   2. Mechanisms underlying the speed of onset of antidepressant response

      • Caroline McGrath, Trevor R. Norman

      Pages 47-61

   3. Calcium signaling cascades, antidepressants and major depressive disorders

      • Ian A. Paul

      Pages 63-79

4. Markers of depression

   1. Front Matter

      Pages 81-81

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   2. The hypothalamic-pituitary-adrenal axis and antidepressant action

      • Timothy G. Dinan

      Pages 83-94

   3. Neuroendocrine markers of depression and antidepressant drug action

      • Philip J. Cowen

      Pages 95-107

   4. Brain cytokines and the psychopathology of depression

      • Brian E. Leonard

      Pages 109-120

5. The future of antidepressants

   1. Front Matter

      Pages 121-121

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   2. Chemistry and pharmacology of novel antidepressants

      • John S. Andrews, Roger M. Pinder

      Pages 123-145

6. Back Matter

   Pages 147-150

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Important clinical issues as the outcome of long term treatment with antidepressants, the time of onset of the antidepressant response and the limitations of the antidepressants currently available are covered in this monograph. Leading researchers in the area of clinical and experimental psychopharmacology critically assess the progress in their specialist fields. The mechanisms of action of antidepressants are considered, followed by clinical research into the role of the hypothalamic-pituitary-adrenal axis and the immune system in the biology of depression and in response to treatment. The final chapter deals with the important chemical entities now undergoing development as antidepressants. The purpose of this monograph is not only to inform but also to stimulate research into the biology of depression and the mechanisms behind the action of effective antidepressants. This monograph is of interest to psychiatrists, psychologists, pharmacologists, neuroscientists and endocrinologists.

• clinical research
• depression
• immune system
• pharmacology
• psychopharmacology
• research

• Pharmacology Department, University College Galway, Galway, Ireland

  Brian E. Leonard

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