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GABA and Sleep

Molecular, Functional and Clinical Aspects

  • Book
  • © 2010

Overview

Editors:
  1. Jaime M. Monti

    1. School of Medicine, Dept. Pharmacology & Therapeutics, Clinics Hospital Montevideo, Montevideo, Uruguay

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  2. Seithikurippu Ratnas Pandi-Perumal

    1. Somnogen, Inc., Toronto, Canada

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  3. Hanns Möhler

    1. Institut für Pharmakologie und, Toxikologie, Universität Zürich, Zürich, Switzerland

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  • Focuses on the neuropsychopharmacology of GABA and its role in sleep and wakefulness

  • Presents neurochemical, electrophysiological, and neuropharmacological approaches to understand GABAergic mechanisms

  • Offers an overview of current approaches and medications

  • Features contributing authors who are leading experts in the field of sleep and neuropharmacology

  • Includes supplementary material: sn.pub/extras

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Table of contents (20 chapters)

  1. Front Matter

    Pages i-xxiv
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  3. Sleep Science and Circuitry

    1. Front Matter

      Pages 119-119
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    2. Sleep and Its Modulation by Substances That Affect GABAA Receptor Function

      • Axel Steiger
      Pages 121-146

    3. Subcortical Neuromodulation of Feedforward and Feedback Inhibitory Microcircuits by the Reticular Activating System

      • J. Josh Lawrence
      Pages 147-168

    4. Function of GABAB and ρ-Containing GABAA Receptors (GABAC Receptors) in the Regulation of Basic and Higher Integrated Sleep-Waking Processes

      • Claude Gottesmann
      Pages 169-188

    5. Interactions Between GABAergic and Serotonergic Processes in the Dorsal Raphe Nucleus in the Control of REM Sleep and Wakefulness

      • Jaime M. Monti
      Pages 189-198

    6. GABA-ergic Modulation of Pontine Cholinergic and Noradrenergic Neurons for REM Sleep Generation

      • Dinesh Pal, Birendra Nath Mallick
      Pages 199-212

    7. Involvement of GABAergic Mechanisms in the Laterodorsal and Pedunculopontine Tegmental Nuclei (LDT–PPT) in the Promotion of REM Sleep

      • Pablo Torterolo, Giancarlo Vanini
      Pages 213-231

    8. GABAergic Mechanisms in the Ventral Oral Pontine Tegmentum: The REM Sleep-Induction Site – in the Modulation of Sleep–Wake States

      • Fernando Reinoso-Suárez, Carmen de la Roza, Margarita L Rodrigo-Angulo, Isabel de Andrés, Ángel Núñez, Miguel Garzón
      Pages 233-252

    9. The Role of GABAergic Modulation of Mesopontine Cholinergic Neurotransmission in Rapid Eye Movement (REM) Sleep

      • Gerald A Marks, Christopher M Sinton
      Pages 253-277

    10. Melatonin and Sleep: Possible Involvement of GABAergic Mechanisms

      • Daniel P. Cardinali, S. R. Pandi-Perumal, Lennard P. Niles, Gregory M. Brown
      Pages 279-301

    11. GABA Involvement in the Circadian Regulation of Sleep

      • J. Christopher Ehlen, Daniel L. Hummer, Ketema N. Paul, H. Elliott Albers
      Pages 303-321

  4. Hypnotics

    1. Front Matter

      Pages 323-323
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    2. Pathophysiology of Sleep Disorders

      • Thomas C. Wetter, Pierre A. Beitinger, Marie E. Beitinger, Bastian Wollweber
      Pages 325-361

    3. Insomnia: Differential Diagnosis and Current Treatment Approach

      • J. F Pagel, Gerald Kram
      Pages 363-381
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Keywords

About this book

GABA (gamma-aminobutyric acid) is the main neurotransmitter regulating sleep. The majority of drugs presently in use for the treatment of sleep disorders act by enhancing GABAergic neuronal inhibition. The GABA system is, therefore, of prime clinical relevance for the therapy of insomnia.

The focus of this volume is on the neuropsychopharmacology and the clinical impact of the GABA system in regulating sleep and wakefulness. It presents molecular, neuropharmacological, systems-biological and clinical approaches to the understanding of the mechanism of action of GABA and GABAergic drugs. It also explores the role of GABA in the basic drives that affect sleep, and the influences that adapt sleep and wakefulness to external events.

 

Editors and Affiliations

  • School of Medicine, Dept. Pharmacology & Therapeutics, Clinics Hospital Montevideo, Montevideo, Uruguay

    Jaime M. Monti

  • Somnogen, Inc., Toronto, Canada

    Seithikurippu Ratnas Pandi-Perumal

  • Institut für Pharmakologie und, Toxikologie, Universität Zürich, Zürich, Switzerland

    Hanns Möhler

Bibliographic Information

  • Book Title: GABA and Sleep

  • Book Subtitle: Molecular, Functional and Clinical Aspects

  • Editors: Jaime M. Monti, Seithikurippu Ratnas Pandi-Perumal, Hanns Möhler

  • DOI: https://doi.org/10.1007/978-3-0346-0226-6

  • Publisher: Springer Basel

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: Springer Basel AG 2010

  • Hardcover ISBN: 978-3-0346-0225-9Published: 30 September 2010

  • Softcover ISBN: 978-3-0348-0740-1Published: 23 September 2014

  • eBook ISBN: 978-3-0346-0226-6Published: 28 September 2010

  • Edition Number: 1

  • Number of Pages: XXIV, 486

  • Topics: Human Physiology

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