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Quantile Regression in Clinical Research

Complete analysis for data at a loss of homogeneity

  • Quantile regression is a novel virtually unpublished approach to data analysis
  • It is excellent for the analysis of clinical data with outliers, skewness, and inconstant variability
  • It is suitable for current big data analysis like omics data and canonical networks
  • 7588 Accesses

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Table of contents (27 chapters)

  1. Front Matter

    Pages i-xii
  2. General Introduction

    • Ton J. Cleophas, Aeilko H. Zwinderman
    Pages 1-8
  3. Mathematical Models for Separating Quantiles from One Another

    • Ton J. Cleophas, Aeilko H. Zwinderman
    Pages 9-19
  4. Simple Univariate Regressions Versus Quantile

    1. Front Matter

      Pages 21-21
    2. Traditional and Robust Regressions Versus Quantile

      • Ton J. Cleophas, Aeilko H. Zwinderman
      Pages 23-34
    3. Autocorrelations Versus Quantile Regressions

      • Ton J. Cleophas, Aeilko H. Zwinderman
      Pages 35-44
    4. Discrete Trend Testing Versus Quantile Regression

      • Ton J. Cleophas, Aeilko H. Zwinderman
      Pages 45-50
    5. Continuous Trend Testing Versus Quantile Regression

      • Ton J. Cleophas, Aeilko H. Zwinderman
      Pages 51-57
    6. Binary Poisson/Negative Binomial Regressions Versus Quantile

      • Ton J. Cleophas, Aeilko H. Zwinderman
      Pages 59-67
    7. Robust Standard Errors Regressions Versus Quantile

      • Ton J. Cleophas, Aeilko H. Zwinderman
      Pages 69-73
    8. Optimal Scaling Versus Quantile Regression

      • Ton J. Cleophas, Aeilko H. Zwinderman
      Pages 75-81
    9. Intercept only Poisson Regression Versus Quantile

      • Ton J. Cleophas, Aeilko H. Zwinderman
      Pages 83-87
  5. Multiple Variables Regressions Versus Quantile

    1. Front Matter

      Pages 89-89
    2. Four Predictors Regressions Versus Quantile

      • Ton J. Cleophas, Aeilko H. Zwinderman
      Pages 91-101
    3. Gene Expressions Regressions, Traditional Versus Quantile

      • Ton J. Cleophas, Aeilko H. Zwinderman
      Pages 103-111
    4. Koenker’s Multiple Variables Analysis with Quantile Modeling

      • Ton J. Cleophas, Aeilko H. Zwinderman
      Pages 113-120
    5. Interaction Adjusted Regression Versus Quantile

      • Ton J. Cleophas, Aeilko H. Zwinderman
      Pages 121-130
    6. Quantile Regression to Study Corona Deaths

      • Ton J. Cleophas, Aeilko H. Zwinderman
      Pages 131-135
    7. Laboratory Values Predict Survival Sepsis, Traditional Regression Versus Quantile

      • Ton J. Cleophas, Aeilko H. Zwinderman
      Pages 137-149
    8. Multinomial Regression Versus Quantile

      • Ton J. Cleophas, Aeilko H. Zwinderman
      Pages 151-163

About this book

Quantile regression is an approach to data at a loss of homogeneity, for example (1) data with outliers, (2) skewed data like corona - deaths data, (3) data with inconstant variability, (4) big data. In clinical research many examples can be given like circadian phenomena, and diseases where spreading may be dependent on subsets with frailty, low weight, low hygiene, and many forms of lack of healthiness. Stratified analyses is the laborious and rather explorative way of analysis, but quantile analysis is a more fruitful, faster and completer alternative for the purpose. Considering all of this, we are on the verge of a revolution in data analysis. The current edition is the first textbook and tutorial of quantile regressions for medical and healthcare students as well as recollection/update bench, and help desk for professionals. Each chapter can be studied as a standalone and covers one of the many fields in the fast growing world of quantile regressions. Step by step analyses of over 20 data files stored at extras.springer.com are included for self-assessment. We should add that the authors are well qualified in their field. Professor Zwinderman is past-president of the International Society of Biostatistics (2012-2015) and Professor Cleophas is past-president of the American College of Angiology(2000-2002). From their expertise they should be able to make adequate selections of modern quantile regression methods for the benefit of physicians, students, and investigators.

 


Authors and Affiliations

  • Albert Schweitzer Hospital, Department Medicine, SLIEDRECHT, The Netherlands

    Ton J. Cleophas

  • Dept. Biostatistics and Epidemiology, Academic Medical Center, Amsterdam, The Netherlands

    Aeilko H. Zwinderman

About the authors

Ton J Cleophas is internist-clinical pharmacologist at the Department of Medicine Albert Schweitzer Hospital Dordrecht the Netherlands. He is also professor of Statistics and member of the Scientific Committee of the European College of Pharmaceutical Medicine Lyon France. He is particularly interested in machine learning methodologies and published many complete-overview-textbooks of the subject.

Aeilko H Zwinderman is professor of Statistics and Chair of the Department of Biostatistics and Epidemiology at the University of Amsterdam the Netherlands. His current work focuses on development and validation of multivariable models, particularly in genetic research, and he is a major developer of penalized canonical analysis. 

Bibliographic Information

  • Book Title: Quantile Regression in Clinical Research

  • Book Subtitle: Complete analysis for data at a loss of homogeneity

  • Authors: Ton J. Cleophas, Aeilko H. Zwinderman

  • DOI: https://doi.org/10.1007/978-3-030-82840-0

  • Publisher: Springer Cham

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Switzerland AG 2021

  • Hardcover ISBN: 978-3-030-82839-4Published: 18 January 2022

  • Softcover ISBN: 978-3-030-82842-4Published: 19 January 2023

  • eBook ISBN: 978-3-030-82840-0Published: 17 January 2022

  • Edition Number: 1

  • Number of Pages: XII, 290

  • Number of Illustrations: 1 b/w illustrations

  • Topics: Biomedicine, general, Applied Statistics, Data Mining and Knowledge Discovery, Big Data

Buy it now

Buying options

eBook USD 54.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book USD 69.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book USD 99.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Other ways to access