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Neoadjuvant Immunotherapy Treatment of Localized Genitourinary Cancers

Multidisciplinary Management

  • Book
  • © 2022

Overview

Editors:
  1. Andrea Necchi

    1. Medical Oncology and Urology, Vita-Salute San Raffaele University, Milano, Italy

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    You can also search for this editor in PubMed   Google Scholar

  2. Philippe E. Spiess

    1. Department of Genitourinary Oncology, University of South Florida, Tampa, USA

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

  • Guides patient management with the most up-to-date scientific and clinical information

  • Stimulates investigative efforts

  • Written by international experts in their fields

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Table of contents (24 chapters)

  1. Front Matter

    Pages i-xviii
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  2. Immune Checkpoint Inhibitors in the Preoperative Setting of Urothelial Bladder Cancer

    1. Front Matter

      Pages 1-1
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    2. Background: State-of-the-Art and Ongoing Developments

      • Marco Moschini, Laura Marandino, Francesco Montorsi
      Pages 3-11

    3. Clinical Case Debate: Neoadjuvant Checkpoint Inhibition Versus Standard Chemotherapy

      • Marco Bandini, Giuseppe Basile, Andrea Gallina
      Pages 13-25

    4. Pathologic Features of Response to Neoadjuvant Therapies in Muscle-Invasive Bladder Cancer: More than Meets the Eye

      • Filippo Pederzoli, Roberta Lucianò, Ewan A. Gibb, Jeffrey S. Ross, Andrea Necchi
      Pages 27-36

    5. Biomarkers Predicting Outcomes Before and After Neoadjuvant Immune Checkpoint Inhibition Therapy for Muscle-Invasive Bladder Cancer

      • Joep J. de Jong, Ewan A. Gibb
      Pages 37-54

    6. The Role of Circulating Tumor DNA Analyses

      • Emil Christensen, Karin Birkenkamp-Demtröder, Lars Dyrskjøt
      Pages 55-61

    7. The Value of Tumor Sample Analyses Before and After Checkpoint Inhibition: Contextualizing the Treatment-Induced Changes in Gene Expression

      • Lauren Folgosa Cooley, A. Gordon Robertson, Joshua J. Meeks
      Pages 63-73

    8. Ongoing Trial and Clinical Trial Endpoint Debate: The Role of Pathologic Response as a Surrogate of Survival Endpoints

      • Praful Ravi, Guru P. Sonpavde
      Pages 75-89

    9. State-of-the-Art and Future Role of Molecular Biomarkers for Patient Selection

      • Tuomas Jalanko, Mathieu Roumiguie, Peter Black
      Pages 91-107

    10. The Role of Immunotherapy as Bladder-Sparing Solution for Muscle-Invasive and Non-muscle-Invasive Bladder Cancer: Current Status and Future Perspectives

      • Giuseppe Basile, Giovanni Enrico Cacciamani, Simone Scuderi, Francesco Barletta, Vito Cucchiara, Elio Mazzone
      Pages 109-122

  3. Management of High-Risk Prostate Cancer in the Perioperative Setting

    1. Front Matter

      Pages 123-123
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    2. An Introduction on Immunotherapy in Prostate Cancer

      • Giorgio Gandaglia, Riccardo Leni, Alberto Briganti
      Pages 125-131

    3. Preoperative Immunotherapy for Prostate Cancer: From Bench to Bedside

      • Charles G. Drake
      Pages 133-143

    4. Clinical Case Debate: Immunotherapy Versus Alternative Therapies in the Neoadjuvant and Adjuvant Setting of Localized, High-Risk Prostate Cancer

      • Giorgio Gandaglia, Riccardo Leni, Giuseppe Rosiello, Nicola Fossati, Alberto Briganti
      Pages 145-160

    5. Biomarkers of Immunotherapy Response and the Future Role of Targeted Therapies in Non-metastatic Prostate Cancer

      • Susan F. Slovin
      Pages 161-176

  4. Management of RCC in the Perioperative Setting

    1. Front Matter

      Pages 177-177
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    2. Cytoreductive Nephrectomy in the Era of Targeted Therapy and Immunotherapy

      • Umberto Capitanio
      Pages 179-185

    3. Clinical Cases Debate: Neoadjuvant Versus Adjuvant Immunotherapy in Localized Renal Cell Carcinoma (RCC)

      • William Paul Skelton IV, Aaron Dahmen, Monica Chatwal, Rohit K. Jain, Jad Chahoud, Philippe E. Spiess
      Pages 187-205

    4. The Search for the Optimal Immunotherapy Sequencing in the Perioperative Setting of RCC

      • Georgia Sofia Karachaliou, Deborah R. Kaye, Daniel J. George, Tian Zhang
      Pages 207-220
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Keywords

About this book

This book aims to provide readers with a current overview of enrolling trials with immune-checkpoint inhibitors in the preoperative setting of localized bladder cancer, renal cell carcinoma, and prostate cancer. The advent of immunotherapy has revolutionized treatments of genitourinary malignancy and evolved strategies for multidisciplinary management. This book explains neoadjuvant checkpoint inhibitors in localized genitourinary cancers, providing insights into the mechanisms of response and development of resistance of cancer cells to immunotherapy. It debates optimal trial design of preoperative checkpoint inhibitors in GU tumors, including optimal endpoints and the role of pathologic response as a surrogate endpoint of survival. It also illuminates clinical management of patients with organ-confined GU tumors, such as side effect management and perioperative safety, before providing an overview of biomarker use for patient selection across the early-stage GU malignancies. Lastly, the book provides the reader with the most up-to-date data emerging from clinical trials involving immunotherapy in early-stage GU malignancies. 


Neoadjuvant Immunotherapy Treatment of Localized Genitourinary Cancers: Multidisciplinary Management provides a comprehensive review of the field, serving as a valuable resource for urologists, medical oncologists, pathologists, fellows in urologic oncology, upper-level residents training in urology and medical oncology, as well as pharmacists interested in RCC clinicians.



Editors and Affiliations

  • Medical Oncology and Urology, Vita-Salute San Raffaele University, Milano, Italy

    Andrea Necchi

  • Department of Genitourinary Oncology, University of South Florida, Tampa, USA

    Philippe E. Spiess

About the editors

Andrea Necchi

Associate Professor, Vita-Salute San Raffaele University
Head of Genitourinary Medical Oncology
IRCCS San Raffaele Hospital and Scientific Institute
Via Olgettina 60, 20132
Milan, Italy




Philippe E. Spiess
Senior Member, Department of GU Oncology
Senior Member, Department of Tumor Biology
Assistant Chief of Surgical Services
Moffitt Cancer Center
Professor, Department of Urology
University of South Florida
Tampa, Florida
USA


Bibliographic Information

  • Book Title: Neoadjuvant Immunotherapy Treatment of Localized Genitourinary Cancers

  • Book Subtitle: Multidisciplinary Management

  • Editors: Andrea Necchi, Philippe E. Spiess

  • DOI: https://doi.org/10.1007/978-3-030-80546-3

  • Publisher: Springer Cham

  • eBook Packages: Medicine, Medicine (R0)

  • Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Switzerland AG 2022

  • Hardcover ISBN: 978-3-030-80545-6Published: 04 January 2022

  • Softcover ISBN: 978-3-030-80548-7Published: 05 January 2023

  • eBook ISBN: 978-3-030-80546-3Published: 03 January 2022

  • Edition Number: 1

  • Number of Pages: XVIII, 315

  • Number of Illustrations: 3 b/w illustrations, 26 illustrations in colour

  • Topics: Internal Medicine

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