Advances in Application of Stem Cells: From Bench to Clinics

1. Front Matter

   Pages i-xi

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2. Basics of Stem Cells

   • Dhvani H. Kuntawala, Glen J. P. McCann

   Pages 1-23

3. Types and Classification of Stem Cells

   • Aayush A. Shah, Firdos Alam Khan

   Pages 25-49

4. Isolation and Characterization of Stem Cells

   • Hassan Ahmed Khan

   Pages 51-71

5. Differentiation of Stem Cells into Neuronal Lineage: In Vitro Cell Culture and In Vivo Transplantation in Animal Models

   • Shahid S. Siddiqui, Khaled Aboshamat, Sivakumar Loganathan, Zeba K. Siddiqui

   Pages 73-102

6. Differentiation of Stem Cells into Cardiomyocyte Lineage: In Vitro Cell Culture, In Vivo Transplantation in Animal Models

   • Sumira Malik, Archna Dhasmana

   Pages 103-121

7. Differentiation of Stem Cells into Hepatocyte Lineage: In Vitro Cell Culture, In Vivo Transplantation in Animal Models

   • Munther Alomari

   Pages 123-154

8. Differentiation of Stem Cells into Pancreatic Lineage: In vitro Cell Culture, in vivo Transplantation in Animal Models

   • Reham M. Balahmar

   Pages 155-191

9. Application of Stem Cells in Treatment of Bone Diseases: Pre-clinical and Clinical Perspectives

   • Mir Sadat-Ali

   Pages 193-213

10. Stem Cells in Regenerative Medicine: Clinical Trials

    • Firdos Alam Khan, Razan Aldahhan, Noor Alrushaid

    Pages 215-242

11. Stem Cell Production: Scale Up, GMP Production, Bioreactor

    • Naseem A. Almezel

    Pages 243-267

12. Stem Cell-Based Products in the Market

    • Alaa A. A. Aljabali, Khaled I. Seetan, Walhan Alshaer, Ejlal Abu-El-Rub, Mohammad A. Obeid, Dua Kamal et al.

    Pages 269-298

13. Commercialization, IPR, and Market of Stem Cell Products

    • Sumira Malik

    Pages 299-314

14. Back Matter

    Pages 315-316

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The field of stem cell biology is expanding with a continued surge of new information related to its applications. Over past few years, stem cells have been extensively used in cell therapy, tissue engineering, in vitro drug testing among others. At the moment there is no single book available which comprehensively describes the significance of various application of stem cells derived from embryonic and adult sources from lab to clinics. In this edited volume, we discuss basics and advanced topics of stem cells to help researchers, students and professional find the most important information in a single source of updated information about stem cells and relevant applications. This book is divided in 12 chapters and covers topics such as in vitro cell culture, 3D cell culture, cell therapy, tissue engineering, cell factory, cell functionality, in vitro drug testing, organ development, autologous transplantation, allogeneic transplantation, adult stem cells, multipotent stem cells, induced pluripotent stem cells, a pluripotent and embryonic stem cells.

• In vitro cell culture
• 3D cell culture
• tissue engineering
• induced pluripotent stem cells
• Transplantation
• organ development
• in vitro drug testing

• Department of Stem Cell Research, Institute for Research and Medical Consultations, Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia

  Firdos Alam Khan

Professor Firdos Alam Khan is Professor and Chairman, Department of Stem Cell Biology, Institute for Research and Medical Consultations (IRMC), Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia. In addition to his research work, he has been teaching (Cell Physiology and Biochemistry and Stem Cell Biology and Regenerative Medicine) courses to MSc students. Professor Khan has done his Ph.D. degree in Zoology with a Neuroscience specialization from Nagpur University, India.  Over the past 25 years, Professor Khan has been involved in teaching various courses such as Cell Biology, Pharmacology, Business of Biotechnology, Biomedicine, Cell & Tissue Engineering, Bioethics & IPR to undergraduate and postgraduate students. Professor Khan was associated with Manipal University (now Manipal Academy of Higher Education) Dubai Campus, United Arab Emirates. He was a Professor and Chairperson, School of Life Sciences and served as Chairman of the Research & Development Program. Professor Khan did his first postdoctoral fellowship from the National Centre for Biological Sciences (NCBS), Bangalore, India, and a second postdoctoral fellowship from Massachusetts Institute of Technology (MIT), Cambridge, USA. Professor Khan has also worked with the Reliance Life Sciences as a Research Scientist in the Stem Cell Research Laboratory. Professor Khan has been granted two US patents in stem cell biology and published 3 US patents on the use of biomaterials in cancer treatment. Professor Khan has authored two books, namely “Biotechnology Fundamentals (textbook)” (1st edition 2009, 2nd edition 2014, 3rd edition 2020) and “Biotechnology in Medical Science” published by CRC Press, Taylor & Francis Group. Also edited one book, “Application of Nanomaterials in Human Health,” in 2020 published by Springer Nature. Professor Khan was an Associate Editor of research journal 3Biotech from 2010 to 2020. Professor Khan has been a recognized reviewer for the scientific journals -Nanomedicine, International Journal of Nanomedicine, Scientific Reports, IET Nanobiotechnology, Drug Design, Development, and Therapy, Journal of Nanostructure in Chemistry, Aging, Current Pharmaceutical Biotechnology, Tissue Engineering, Nano Express, . He has published more than 70 research papers in peer-reviewed journals.  Professor Khan is currently studying the impact of different biomolecules, biomaterials, and nanomaterials on stem cell differentiation and cancer treatment.

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