Anoikis

How the Extracellular Matrix Regulates Life-or-Death Decisions

Editors: Frisch, Steven M. (Ed.)

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  • Is the first to summarize the past 26 years of research in this field
  • Provides both mechanistic and translational information regarding anoikis, in a convenient format
  • Serves as a unique resource for cell-, molecular- and cancer biologists, as well as their students
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eBook 106,99 €
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  • ISBN 978-3-030-73856-3
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Hardcover 135,19 €
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  • ISBN 978-3-030-73854-9
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About this book

Anoikis is defined broadly as apoptosis that is inhibited by appropriate cell-matrix interactions.  Normal and tumor cells vary widely in their sensitivity to anoikis, but, in general, metastatic tumor cells are inevitably anoikis-resistant.  In particular, tumor cells that possess a cancer stem cell or mesenchymal phenotype, arising from the oncogenic Epithelial-Mesenchymal Transition (EMT), are transcriptionally re-programmed to resist anoikis.  While the anoikis response occurs through the mitochondrial pathway typically found in other apoptotic responses (e.g., DNA damage, death receptors, oxidative stress), the regulation of anoikis by cell-matrix signalling is unique and only partially characterized.  The uniqueness of anoikis is: a. regulation by integrins, non-integrin matrix receptors, and the signaling complexes associated with them; b. regulation by metabolic changes occurring in response to attachment/detachment;  c. regulation by oncogenes and tumor suppressor genes d. regulation by tumor microenvironment;  e. regulation by EMT.

About the authors

Steven M. Frisch received his Ph.D. in Biochemistry from the University of California, Berkeley (where he worked with Dr. Zena Werb, at U.C.S.F). Following postdoctoral training at the M.I.T. Center for Cancer Research, Dr. Frisch served on the faculties of Washington University, St. Louis and the Sanford-Burnham-Prebys Institute, and is currently a Professor of Biochemistry at West Virginia University. Dr. Frisch has published extensively in the area of cancer cell biology and is internationally recognized for his important contributions to the field.

Table of contents (10 chapters)

Table of contents (10 chapters)

Buy this book

eBook 106,99 €
price for Spain (gross)
  • ISBN 978-3-030-73856-3
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover 135,19 €
price for Spain (gross)
  • ISBN 978-3-030-73854-9
  • Free shipping for individuals worldwide
  • Institutional customers should get in touch with their account manager
  • Covid-19 shipping restrictions
  • Usually ready to be dispatched within 3 to 5 business days, if in stock
  • The final prices may differ from the prices shown due to specifics of VAT rules
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Bibliographic Information

Bibliographic Information
Book Title
Anoikis
Book Subtitle
How the Extracellular Matrix Regulates Life-or-Death Decisions
Editors
  • Steven M. Frisch
Copyright
2021
Publisher
Springer International Publishing
Copyright Holder
Springer Nature Switzerland AG
eBook ISBN
978-3-030-73856-3
DOI
10.1007/978-3-030-73856-3
Hardcover ISBN
978-3-030-73854-9
Edition Number
1
Number of Pages
VIII, 202
Number of Illustrations
6 b/w illustrations
Topics