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Tumor Suppressor Par-4

Structural Features, Molecular Mechanisms and Function

  • Book
  • © 2022

Overview

Editors:
  1. Vivek M. Rangnekar

    1. Associate Director, Markey Cancer Center, University of Kentucky, Lexington, USA

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  • Highlights the structural features and molecular mechanisms of Par-4 function by global researchers

  • Provides researchers and clinicians with new insights into potential drug discovery and development for cancer and other human diseases

  • Describes future directions for research studies and novel, translational facets of the tumor suppressor protein

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Table of contents (11 chapters)

  1. Front Matter

    Pages i-x
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  2. Discovery and Overview of Par-4

    • Saptadwipa Ganguly, Ravshan Burikhanov, Shirley Qiu, Vivek M. Rangnekar
    Pages 1-59

  3. Par-4 in Cell Cycle Regulation

    • Yanquan Zhang, Fengyi Mao, Xiaoqi Liu
    Pages 61-93

  4. Conformational Studies of the Par-4 C-Terminal Domain

    • David S. Libich, Samjhana Pandey, Steven M. Pascal
    Pages 95-126

  5. Structural Analysis of Par-4 and Crystallographic Analysis of the Regulatory Domain

    • J. Labahn, U. K. Tiruttani Subhramanyam
    Pages 127-150

  6. Regulation of Par-4 by Ubiquitinases

    • Nikhil Hebbar, Vivek M. Rangnekar
    Pages 151-183

  7. Regulation of Par-4 Function by Phosphorylation

    • Margaux Sevin, John E. Eriksson, Valérie Mezger, Carmen Garrido, Aurélie de Thonel
    Pages 185-208

  8. Role of Par-4 in GRP78 Translocation

    • Daniel Bastida-Ruiz, Alexia Childress, Marie Cohen
    Pages 209-238

  9. PAR-4 in the Regulation of Stem Cell Death and Embryo Development

    • Ahmed Elsherbini, Erhard Bieberich
    Pages 239-252

  10. RASSF2 and the PAR-4 Connection

    • Howard Donninger, Geoffrey J. Clark
    Pages 253-262

  11. Regulation of Tumor Suppressor Par-4 by Ceramide

    • Sehamuddin Galadari, Anees Rahman Cheratta, Faisal Thayyullathil
    Pages 263-291

  12. PAWR as a Direct SRC-1/HOXC11 Suppression Target

    • Damir VareÅ¡lija, Leonie Young
    Pages 293-308

  13. Back Matter

    Pages 309-323
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Keywords

About this book

Par-4 is a tumor suppressor protein first discovered and identified in 1993 by Dr. Vivek Rangnekar’s laboratory in prostate cancer cells undergoing apoptosis.  Par-4 (later also known as PAWR) is a naturally occurring tumor suppressor. Studies have indicated that Par-4 selectively induces apoptosis in cancer cells while leaving normal, healthy, cells unaffected. Mechanisms contributing to the cancer-selective action of Par-4 have been associated with protein kinase A activation of intracellular Par-4 in cancer cells or GRP78 expression primarily on the surface of cancer cells. Par-4 is downregulated, inactivated or mutated in diverse cancers. This first of two volumes will be the first on the market on the topic of Par-4, and will provide the opportunity for researchers to discuss the future direction of studies, broaden the scope of research, and contribute a more complete understanding of the molecule’s structural features, key functional domains, regulation and relevant basic and clinical/translational facets.

Editors and Affiliations

  • Associate Director, Markey Cancer Center, University of Kentucky, Lexington, USA

    Vivek M. Rangnekar

About the editor

​Vivek M. Rangnekar, Ph.D. is Professor and Alfred Cohen Chair in Oncology Research in the Department of Radiation Medicine and Associate Director of the Markey Cancer Center at the University of Kentucky. His laboratory studies the molecular cross-talk between oncogenes and tumor suppressor genes in an effort to tilt the balance in favor of tumor suppressor function. Dr. Rangnekar originally discovered and identified the tumor suppressor protein Par-4/PAWR in 1993. 

Bibliographic Information

  • Book Title: Tumor Suppressor Par-4

  • Book Subtitle: Structural Features, Molecular Mechanisms and Function

  • Editors: Vivek M. Rangnekar

  • DOI: https://doi.org/10.1007/978-3-030-73572-2

  • Publisher: Springer Cham

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: Springer Nature Switzerland AG 2022

  • Hardcover ISBN: 978-3-030-73571-5Published: 09 January 2022

  • eBook ISBN: 978-3-030-73572-2Published: 08 January 2022

  • Edition Number: 1

  • Number of Pages: X, 323

  • Number of Illustrations: 3 b/w illustrations, 81 illustrations in colour

  • Topics: Cancer Research, Oncology

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