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Cellular Primary Immunodeficiencies

  • Features updated management and all the latest genetic sof cellular primary immunodeficiencies
  • Offers in-depth description of the basis of cellular immune responses
  • Valued companion to immunologists, pediatricians, rheumatologists, oncologists, internists, and infectious disease specialists

Part of the book series: Rare Diseases of the Immune System (RDIS)

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Table of contents (19 chapters)

  1. Front Matter

    Pages i-xiv
  2. Primary Immunodeficiencies

    • Lorenzo Cosmi, Boaz Palterer, Francesco Annunziato
    Pages 1-4
  3. Genetics of Cellular Immunodeficiencies

    • Natalie Frede
    Pages 5-24
  4. Phenocopies of Primary Immunodeficiency Diseases

    • Nadezhda Camacho-Ordonez, Mario Milco D’Elios
    Pages 25-42
  5. Dysfunctional Immune Synapses in T Cell Immunodeficiencies

    • Nagaja Capitani, Laura Patrussi, Mario Milco D’Elios, Cosima Tatiana Baldari
    Pages 43-63
  6. Mucosal Immunity in Primary Immunodeficiencies

    • Arianna Troilo, Nadezhda Camacho-Ordonez, Chiara Della Bella, Mario Milco D’Elios
    Pages 65-74
  7. Combined Immunodeficiencies

    • Francesco Liotta, Lorenzo Salvati
    Pages 75-96
  8. Congenital Defects of Phagocytes

    • Delfien J. Bogaert, Filomeen Haerynck
    Pages 97-176
  9. Defects in Intrinsic and Innate Immunity

    • Laia Alsina, Carlos Rodriguez-Gallego, Ana Esteve-Solé, Alexandru Vlagea, Rebeca Pérez de Diego, Rubén Martínez-Barricarte et al.
    Pages 177-212
  10. Diseases of Immune Dysregulation

    • Michele Proietti
    Pages 213-244
  11. IPEX Syndrome and IPEX-Related Disorders

    • Ebe Schiavo, Rayan Goda, Sara Ciullini Mannurita, Eleonora Gambineri
    Pages 245-278
  12. Autoinflammatory Disorders

    • Mark Kacar, Sinisa Savic
    Pages 279-313
  13. Lung in Cellular Immunodeficiencies

    • Emanuele Vivarelli, Lorenzo Cosmi
    Pages 315-341
  14. Gut Involvement in Cellular Immunodeficiencies

    • Arianna Troilo, Natalie Frede, Chiara Della Bella, Mario Milco D’Elios
    Pages 343-360
  15. Malignancies in Cellular Immunodeficiencies

    • Jovanka R. King, Siobhan O. Burns, Emma C. Morris
    Pages 361-389
  16. Autoimmunity in Cellular Immunodeficiencies

    • Boaz Palterer, Gianfranco Vitiello, Emanuele Vivarelli, Paola Parronchi
    Pages 391-425
  17. Differential Diagnostic in Cellular Immunodeficiencies

    • Isabella Quinti, Marzia Miglionico, Cinzia Milito
    Pages 427-440
  18. Management of Cellular Immunodeficiencies

    • Carlo Agostini, Alessandro Dell’Edera
    Pages 441-453
  19. Vaccines in Cellular Immunodeficiencies

    • Chiara Azzari, Clementina Canessa
    Pages 455-471
  20. Gene Therapy in Cellular Immunodeficiencies

    • Tom Fox, Claire Booth, Emma C. Morris
    Pages 473-497

About this book

This volume of the series Rare Diseases of the Immune System presents detailed state of the art knowledge on the cellular primary immunodeficiencies; it includes extensive coverage of both basic science discoveries and the latest clinical advances in the field. The book is structured in accordance with the most recent classification of PIDs and also covers updates on the T cell immunological synapse. Readers will find comprehensive, in-depth descriptions of novel cellular PID genes and related clinical applications, mucosal T cells, and the various clinical phenotypes of cellular PIDs. Cellular Primary Immunodeficiencies  will be of high value for immunologists, pediatricians, rheumatologists, oncologists, internists, and infectious disease specialists and will also be informative for MD, Master and PhD students.

Editors and Affiliations

  • Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy

    Mario Milco D'Elios

  • Department of Life Sciences, University of Siena, Siena, Italy

    Cosima Tatiana Baldari

  • Department of Experimental and Clinical Medicine, University of Florence, Firenze, Florence, Italy

    Francesco Annunziato

About the editors

Mario Milco D’Elios obtained his degree cum laude in Medicine and Surgery from the University of Florence (1990)  after which he specialized with honors in Allergology and Clinical Immunology (1993) at the same university. Member of Italian Society of Clinical Immunology and Allergy, he is also member of the European Scientific Committee on Gastrointestinal lymphomas since 2006 and member of the European Scientific Group on Immunology of Helicobacter pylori infection since 2004. Professor of Internal Medicine at the University of Florence, his fields of expertise are immunodeficiency, mucosal immunology and T cells.

Cosima T Baldari graduated in Biological Sciences from the University of Rome (1976). After a postdoctoral fellowship at the European Molecular Biology Laboratory (EMBL) in Heidelberg, Germany, she joined the University of Rome in 1981 as staff scientist, returning to EMBL as visiting scientist in 1983. In 1986 she moved to the University of Siena, where she set up her research group, starting as Associate Professor before being elected Full Professor in 2000. Prof. Baldari is Chair of the Department of Life Sciences, member of the Academic Senate and of  the European Molecular Biology Organization (EMBO),  the AcademiaNet. She also sits in the Scientific Advisory Board of Pompeu Fabra University (Barcelona, Spain). Her fields of expertise include immunodeficiency and immunological synapses.

Francesco Annunziato Full professor of General Pathology at the University of Florence. Gained his degree in Biological Sciences (1994, Florence University), and PhD in Clinical Immunology (honors, 1999, Bari University). Former EiC of the European Journal of Immunology (journal of European Federation of Immunological Societies EFIS) 2016-2019, then EiC of Immunology Letters (other official EFIS journal).  Past President Human Health Science School (Florence University 2016-2020), Head of the Clinical Sciences PhD program in Clinical Sciences (Florence University 2015-2018). Director of the Regenerative Therapy Unit at the University Hospital Careggi in Florence (AOUC) from 2010 to 2016. Since 2016 Director of the FlowCytometry diagnostic Corelab at the University Hospital Careggi in Florence (AOUC) and appointed 2020 Director of the Department of Clinical and Experimental Medicine, and  member of the Academic Senate of the University of Florence. His research work focuses on three main topics, which are: Human Th cell subsets characterization, Human T regulatory cells (Treg) characterization, Characterization of the immunomodulatory activity of human mesenchymal stem cells.


Bibliographic Information

  • Book Title: Cellular Primary Immunodeficiencies

  • Editors: Mario Milco D'Elios, Cosima Tatiana Baldari, Francesco Annunziato

  • Series Title: Rare Diseases of the Immune System

  • DOI: https://doi.org/10.1007/978-3-030-70107-9

  • Publisher: Springer Cham

  • eBook Packages: Medicine, Medicine (R0)

  • Copyright Information: Springer Nature Switzerland AG 2021

  • Hardcover ISBN: 978-3-030-70106-2Published: 12 June 2021

  • Softcover ISBN: 978-3-030-70109-3Published: 13 June 2022

  • eBook ISBN: 978-3-030-70107-9Published: 10 June 2021

  • Series ISSN: 2282-6505

  • Series E-ISSN: 2283-6403

  • Edition Number: 1

  • Number of Pages: XIV, 513

  • Number of Illustrations: 3 b/w illustrations, 38 illustrations in colour

  • Topics: Rheumatology, Immunology, Gene Therapy

Buy it now

Buying options

eBook USD 129.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book USD 169.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book USD 249.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Other ways to access