Overview
- Written and edited by experts in the fields of pathology and neuropathology
- Includes the integration of molecular and histomorphological features pertinent to glioblastoma classification
- Includes chapters dedicated to resources for neuropathologists in low and middle income countries
Part of the book series: Molecular Pathology Library (MPLB)
Access this book
Tax calculation will be finalised at checkout
Other ways to access
Table of contents (14 chapters)
-
Front Matter
-
General Principles
-
Front Matter
-
-
Molecular Pathology of Glioblastoma
-
Front Matter
-
-
Key Molecular Pathways in Glioblastoma Development and Progression
-
Front Matter
-
-
Back Matter
Keywords
About this book
This volume provides a balanced and realistic review of the current state of glioblastoma, ranging from traditional histological review, molecular pathology of glioma, modern radiomics, neurosurgical focus, and integration of treatment plans by neuro-oncologists. The book reviews basic principles such as epidemiology and etiology, and modern 2016 WHO classification of CNS tumors. Chapters cover a general overview of common molecular techniques used in molecular pathology, molecular pathology in a developing country, key drivers of patient outcomes and predictors of response to radiation and/or chemotherapy treatment, and immunohistochemical surrogates for key molecular pathology. It concludes with reviews on radiomics, animal and stem cell models of glioblastoma, and a chapter on the emerging field of Glioblastoma Neuroscience.
Precision Molecular Pathology of Glioblastoma is intended for pathology residents and fellows interested in glioblastoma, generalsurgical pathologists who need reviews on how to implement modern glioblastoma classification, as well as neuro-radiologists, oncologists, and radiation oncologists needing a holistic perspective to glioblastoma diagnosis and management.Editors and Affiliations
About the editors
The Ohio State University College of Medicine
Department of Pathology
333 West 10th Ave.
Columbus, OH 43210
Dr. Otero is the Director of Neuropathology at The Ohio State University College of Medicine. Neuropathology at Ohio State is responsible for all Surgical Neuropathology and Autopsy Diagnostics for James Cancer Center and Wexner Medical Center, in addition to reviewing consults from community pathologists throughout the United States. Dr. Otero obtained his M.D., Ph.D. degree from Northwestern University (Chicago, IL) where he was mentored by Dr. John Kessler during his graduate dissertation. He then transitioned to University of California, San Francisco for anatomic pathology and neuropathology residency, followed by a post-doctoral fellowship in the laboratory of Dr. David Rowitch. Dr. Otero is an expert in developmental neurobiologyand surgical neuropathology.
Aline Becker, M.D., Ph.D.
The Ohio State University Comprehensive Cancer Center - James Cancer Hospital
Department of Radiation Oncology400 W 12th Avenue
Columbus, OH 43210
E-Mail: aline.becker@osumc.edu
Dr. Becker is a physician-scientist formally trained as anatomic pathologist in her home country of Brazil, with large experience in Neuropathology and Molecular Pathology of adult and pediatric brain tumors. She obtained her Neuropathology training at the University of Sao Paulo, campus Ribeirao Preto, a world-renowned institution and one of the premier academic centers for Neuro-Oncology in Brazil. Her Doctoral degree in Molecular Pathology was obtained under the mentorship from Dr. Rui Manuel Reis. She is currently the Research Neuropathologist (Senior Research Associate) in the Chakravarti laboratory at The Ohio State University, where she has worked inthe discovery and validation of molecular biomarkers, development of new treatments with small molecule inhibitors and FLASH radiation, and elucidation of treatment resistance mechanisms in glioblastoma.
Bibliographic Information
Book Title: Precision Molecular Pathology of Glioblastoma
Editors: José Javier Otero, Aline Paixao Becker
Series Title: Molecular Pathology Library
DOI: https://doi.org/10.1007/978-3-030-69170-7
Publisher: Springer Cham
eBook Packages: Medicine, Medicine (R0)
Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Switzerland AG 2021
Hardcover ISBN: 978-3-030-69169-1Published: 01 May 2021
Softcover ISBN: 978-3-030-69172-1Published: 02 May 2022
eBook ISBN: 978-3-030-69170-7Published: 30 April 2021
Series ISSN: 1935-987X
Series E-ISSN: 1935-9888
Edition Number: 1
Number of Pages: XV, 266
Number of Illustrations: 7 b/w illustrations, 55 illustrations in colour