Physiology in Health and Disease

Inflammation, Infection, and Microbiome in Cancers

Evidence, Mechanisms, and Implications

Editors: Sun, Jun (Ed.)

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  • Highlights connections between infection, inflammation and various cancers
  • Offers insights into the progress of immune therapy and stem cell research in cancer
  • Discusses emerging roles of the microbiome in pathogenesis of cancers and outcome of therapy
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eBook 117,69 €
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  • ISBN 978-3-030-67951-4
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Hardcover 155,99 €
price for Spain (gross)
  • ISBN 978-3-030-67950-7
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About this book

This book offers a summary and discussion of the advances of inflammation and infection in various cancers. The authors cover the classically known virus infections in cancer, novel roles of other pathogens (e.g. bacteria and fungi), as well as biomarkers for diagnosis and therapy. Further, the chapters highlight the progress of immune therapy, stem cells and the role of the microbiome in the pathophysiology of cancers.

Readers will gain insights into complex microbial communities, that inhabit most external human surfaces and play a key role in health and disease. Perturbations of host-microbe interactions often lead to altered host responses that can promote cancer development. Thus, this book highlights emerging roles of the microbiome in pathogenesis of cancers and outcome of therapy. The focus is on mechanistic concepts that underlie the complex relationships between host and microbes. Approaches that can inhibit infection, suppress chronic inflammation and reverse the dysbiosis are discussed, as a means for restoring the balance between host and microbes.

This comprehensive work will be beneficial to researchers and students interested in infectious diseases, microbiome, and cancer as well as clinicians and general physiologists.

About the authors

Dr. Jun Sun is a tenured Professor of Medicine at the University of Illinois at Chicago (UIC), U.S.A.. She is an elected fellow of American Gastroenterological Association (AGA) and American Physiological Society (APS). She chairs the AGA microbiome section. Her research interests are host-microbiome interactions in inflammation and cancer. Her key achievements include 1) characterization of vitamin D receptor regulation of intestinal barrier and microbiome in inflammation and cancer, 2) identification of dysbiosis and intestinal dysfunction in amyotrophic lateral sclerosis (ALS), 3) characterization of bacteria in regulating intestinal stem cells and leading to cancer, and 4) identification and characterization of the Salmonella protein AvrA in host-bacterial interactions. Dr. Sun has published over 190 scientific articles in peer-reviewed journals, including Gut, Gastroenterolog, Cell Stem Cells, Nature Genetics, JBC, Autophagy, American Journal of Pathology, & American Journal of Physiology-GI.  She is the leading editor of 4 books on microbiome, including a Nature/Spring book entitled “Mechanisms underlying host-microbiome interactions in pathophysiology of human diseases.”  This book has shown a novel theme and multiple disciplinary topics of microbiome research for a broad audience. She is the author of Nature/Spring book “Statistical Analysis of Microbiome Data with R. This timely book addresses the statistical modelling and analysis of microbiome data using cutting-edge R software. She serves on the editorial board of more than 10 peer-reviewed international scientific journals. She services study sections for the NIH, American Cancer Society, and other national and international research foundations. She has been invited to chair meetings on microbiome, be a keynote speaker, and to write reviews, editorials, and comments on microbiome in human diseases published for peer-reviewed journals. She is actively involved in advocating microbiome research at the international, national, and institutional levels. Her research is supported by the NIH, DOD, VA, and other research awards.

Dr. Sun is a believer of scientific art and artistic science. She enjoys writing her science papers in English and poems in Chinese. She teaches her medical fellows biomedical knowledge and also the way to translate the Chinese poems. In addition to her research papers and books, her poetry collection《让时间停留在这一刻 》“Let time stay still at this moment”, is published in 2018 by the Chinese Literature and History Press (中国文史出版社).

 

Table of contents (16 chapters)

Table of contents (16 chapters)

Buy this book

eBook 117,69 €
price for Spain (gross)
  • ISBN 978-3-030-67951-4
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover 155,99 €
price for Spain (gross)
  • ISBN 978-3-030-67950-7
  • Free shipping for individuals worldwide
  • Institutional customers should get in touch with their account manager
  • Covid-19 shipping restrictions
  • Usually ready to be dispatched within 3 to 5 business days, if in stock
  • The final prices may differ from the prices shown due to specifics of VAT rules
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Bibliographic Information

Bibliographic Information
Book Title
Inflammation, Infection, and Microbiome in Cancers
Book Subtitle
Evidence, Mechanisms, and Implications
Editors
  • Jun Sun
Series Title
Physiology in Health and Disease
Copyright
2021
Publisher
Springer International Publishing
Copyright Holder
The American Physiological Society
eBook ISBN
978-3-030-67951-4
DOI
10.1007/978-3-030-67951-4
Hardcover ISBN
978-3-030-67950-7
Series ISSN
2625-252X
Edition Number
1
Number of Pages
XII, 509
Number of Illustrations
3 b/w illustrations, 28 illustrations in colour
Topics