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Enzyme Cascade Design and Modelling

  • Book
  • © 2021

Overview

Editors:
  1. Selin Kara

    1. Department of Biological and Chemical Engineering, Aarhus University, Aarhus, Denmark

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    You can also search for this editor in PubMed   Google Scholar

  2. Florian Rudroff

    1. Institute of Applied Synthetic Chemistry, TU Wien, Vienna, Austria

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    You can also search for this editor in PubMed   Google Scholar

  • Creates the basis for pathway design via the concept of ‘biocatalytic retrosynthesis’
  • Enhances the readers’ understanding on kinetic modelling and reaction engineering
  • Introduces process design, process modelling, monitoring and control of catalytic cascades
  • Discusses both multi-enzymatic and chemo-enzymatic cascades
  • Provides an outlook on industrial applications and future developments

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Table of contents (11 chapters)

  1. Front Matter

    Pages i-vii
    Download chapter PDF

  2. Introduction

    • Selin Kara, Florian Rudroff
    Pages 1-6

  3. Enzyme Cascade Design: Retrosynthesis Approach

    • William Finnigan, Sabine L. Flitsch, Lorna J. Hepworth, Nicholas J. Turner
    Pages 7-30

  4. Multi-Enzymatic Cascades In Vitro

    • Sandy Schmidt, Anett Schallmey, Robert Kourist
    Pages 31-48

  5. Multi-Enzymatic Cascades In Vivo

    • Lydia Suchy, Florian Rudroff
    Pages 49-63

  6. Design and Development of Chemoenzymatic Cascades

    • Harald Gröger
    Pages 65-89

  7. Enzyme Cascade Kinetic Modelling

    • Martina Sudar, Zvjezdana Findrik Blažević
    Pages 91-108

  8. Enzyme Cascade Reaction Engineering

    • Philipp Petermeier, Selin Kara
    Pages 109-124

  9. Enzyme Cascade Process Design and Modelling

    • John M. Woodley
    Pages 125-139

  10. Enzyme Cascade Reaction Monitoring and Control

    • Robert Hiessl, Joscha Kleber, Andreas Liese
    Pages 141-163

  11. Enzymatic Cascade Reactions in Non-Conventional Media

    • Javier González-Sabín
    Pages 165-178

  12. Perspectives

    • Selin Kara, Florian Rudroff
    Pages 179-181
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Keywords

About this book

This book provides a comprehensive overview of the recent developments achieved in the field of chemo/enzymatic cascades with topics spanning from design (in vitro and in vivo) to kinetic- and process modelling as well as process control. Opportunities and challenges of building multi-step chemo/enzymatic reactions are discussed, whereby the latter are critically assessed in each chapter and methods to ease the implementation are explored. Both, multi-enzymatic cascades and chemo-enzymatic cascades are presented with the motivation of combining the strengths of these two worlds (e.g. selectivity, activity and robustness) not neglecting the obstacles and challenges of such endeavour. Furthermore, the use of non-conventional media for catalytic cascade reactions, recent achievements and potential for future developments in a technical environment are addressed.   



Editors and Affiliations

  • Department of Biological and Chemical Engineering, Aarhus University, Aarhus, Denmark

    Selin Kara

  • Institute of Applied Synthetic Chemistry, TU Wien, Vienna, Austria

    Florian Rudroff

About the editors

Prof. Dr. Selin Kara, Department of Biological and Chemical Engineering, Aarhus University, Aarhus, Denmark


Assoc. Prof. Dr. Florian Rudroff, Institute of Applied Synthetic Chemistry, Vienna University of Technology, Vienna, Austria   




Bibliographic Information

  • Book Title: Enzyme Cascade Design and Modelling

  • Editors: Selin Kara, Florian Rudroff

  • DOI: https://doi.org/10.1007/978-3-030-65718-5

  • Publisher: Springer Cham

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: Springer Nature Switzerland AG 2021

  • Hardcover ISBN: 978-3-030-65717-8Published: 25 February 2021

  • Softcover ISBN: 978-3-030-65720-8Published: 25 February 2022

  • eBook ISBN: 978-3-030-65718-5Published: 24 February 2021

  • Edition Number: 1

  • Number of Pages: VII, 181

  • Number of Illustrations: 42 b/w illustrations, 61 illustrations in colour

  • Topics: Protein Science, Biochemical Engineering, Enzymology, Bioorganic Chemistry

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