Overview
- Provides a comprehensive overview on pathogenic mechanisms, diagnostic aspects and treatment of necrotizing soft tissue infections
- Illustrated by various case reports
- Discusses the application of systems medicine in necrotizing soft tissue infections
Part of the book series: Advances in Experimental Medicine and Biology (AEMB, volume 1294)
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Table of contents (12 chapters)
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Front Matter
Keywords
About this book
Necrotizing soft tissue infections are rapidly spreading infections that may cause extensive soft tissue or limb loss, multiorgan failure and are associated with a considerable fatality rate. It is undisputed that rapid diagnosis and prompt intervention is directly related to survival. The initial presentation may be limited to unspecific symptoms such as tenderness, swelling, erythema and pain. Thus, diagnosis and management are challenging due to heterogeneity in clinical presentation, in co-morbidities, in microbiological aetiology, as well as in the pathogenic mechanisms. An international and multidisciplinary consortium, INFECT, has for the last 6 years been pursuing research aimed to advance the understanding of the clinical and pathogenic aspects of these infections. A central part has been to create a comprehensive clinical registry and associated biobank which have also formed the basis for the experimental studies. Using the INFECT patient cohort, as well as an integrated systems biology approach in patients and clinically relevant experimental models, an advanced insight of diagnostic features, causative microbial agents, treatment strategies, and pathogenic mechanisms (host and bacterial disease traits and their underlying interaction network) has been obtained.
Editors and Affiliations
Bibliographic Information
Book Title: Necrotizing Soft Tissue Infections
Book Subtitle: Clinical and Pathogenic Aspects
Editors: Anna Norrby-Teglund, Mattias Svensson, Steinar Skrede
Series Title: Advances in Experimental Medicine and Biology
DOI: https://doi.org/10.1007/978-3-030-57616-5
Publisher: Springer Cham
eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)
Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Switzerland AG 2020
Hardcover ISBN: 978-3-030-57615-8Published: 21 October 2020
Softcover ISBN: 978-3-030-57618-9Published: 22 October 2021
eBook ISBN: 978-3-030-57616-5Published: 20 October 2020
Series ISSN: 0065-2598
Series E-ISSN: 2214-8019
Edition Number: 1
Number of Pages: VIII, 207
Number of Illustrations: 13 b/w illustrations, 47 illustrations in colour
Topics: Medical Microbiology, Infectious Diseases, Microbiology