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Bone Regulators and Osteoporosis Therapy

  • Book
  • © 2020

Overview

Editors:
  1. Paula H. Stern

    1. Department of Pharmacology, Northwestern University Feinberg School of Medicine, Chicago, USA

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  • Provides an understanding of the mechanisms by which multiple factors and therapeutic agents affect bones
  • Gives an overview of the genetics of bone disorders and discusses the pathophysiology of osteoporosis
  • Maximizes insights in current and potential osteoporosis therapies and treatments

Part of the book series: Handbook of Experimental Pharmacology (HEP, volume 262)

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Table of contents (20 chapters)

  1. Front Matter

    Pages i-x
    Download chapter PDF

  2. The Cells of Bone and Their Interactions

    • Niloufar Ansari, Natalie A. Sims
    Pages 1-25

  3. PTH and PTHrP Actions on Bone

    • Larry J. Suva, Peter A. Friedman
    Pages 27-45

  4. Vitamin D and Bone

    • Sylvia Christakos, Shanshan Li, Jessica DeLa Cruz, Lieve Verlinden, Geert Carmeliet
    Pages 47-63

  5. Gonadal Hormones and Bone

    • Tomohiko Yoshida, Jun Wang, Paula H. Stern
    Pages 65-91

  6. Thyroid Hormones, Glucocorticoids, Insulin, and Bone

    • Peter Lakatos, Balazs Szili, Bence Bakos, Istvan Takacs, Zsuzsanna Putz, Ildiko Istenes
    Pages 93-120

  7. Growth Factors, Carrier Materials, and Bone Repair

    • Erin L. Hsu, Stuart R. Stock
    Pages 121-156

  8. Prostaglandins and Bone

    • Carol Pilbeam
    Pages 157-175

  9. Cytokines and Bone: Osteoimmunology

    • Joseph Lorenzo
    Pages 177-230

  10. Chemokines and Bone

    • Annette Gilchrist
    Pages 231-258

  11. Calcium and Bone

    • Ian R. Reid, Sarah M. Bristow
    Pages 259-280

  12. FGF23 and Bone and Mineral Metabolism

    • Seiji Fukumoto
    Pages 281-308

  13. The Central Regulation of Bone Mass: Genetic Evidence and Molecular Bases

    • Gerard Karsenty
    Pages 309-323

  14. Genetics of Skeletal Disorders

    • Fadil M. Hannan, Paul J. Newey, Michael P. Whyte, Rajesh V. Thakker
    Pages 325-351

  15. Pathogenesis of Osteoporosis

    • Ahmed Al Saedi, Nicole Stupka, Gustavo Duque
    Pages 353-367

  16. Structural and Metabolic Assessment of Bone

    • Radhika R. Narla, Susan M. Ott
    Pages 369-396

  17. Osteoporosis Therapeutics 2020

    • Roland Kocijan, Klaus Klaushofer, Barbara M. Misof
    Pages 397-422

  18. Reduced Bone Modeling and Unbalanced Bone Remodeling: Targets for Antiresorptive and Anabolic Therapy

    • Sabashini K. Ramchand, Ego Seeman
    Pages 423-450

  19. New Targets and Emergent Therapies for Osteoporosis

    • Robert Brommage
    Pages 451-473

  20. Drugs Causing Bone Loss

    • Peter Vestergaard
    Pages 475-497
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Keywords

About this book

This volume is designed to provide an understanding of current and potential therapies for osteoporosis. The opening chapter introduces the  cells of bone and their interactions.  Several following chapters describe factors affecting bone including systemic hormones with significant effects on bone, and local mediators including growth factors, prostaglandins, cytokines and chemokines. Topics that have commanded particular attention recently are calcium, FGF-23, nervous system bone interactions. Drugs that cause bone loss provide important information on mechanism as well as therapeutic considerations. An overview of the genetics of bone disorders and a discussion of the pathophysiology of osteoporosis establish the clinical context. The final chapters discuss current and potential osteoporosis treatments. 

Editors and Affiliations

  • Department of Pharmacology, Northwestern University Feinberg School of Medicine, Chicago, USA

    Paula H. Stern

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