Illuminating Colorectal Cancer Genomics by Next-Generation Sequencing

A Big Chapter in the Tale

Editors: El Bairi, Khalid (Ed.)

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  • Reviews the potential of next-generation sequencing in colorectal cancer management
  • Discusses the role of NGS in understanding the link between gut microbiota, immune-checkpoint blockade and CRC
  • Highlights the limitations of NGS
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eBook 117,69 €
price for Spain (gross)
  • ISBN 978-3-030-53821-7
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
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  • Immediate eBook download after purchase
Hardcover 145,59 €
price for Spain (gross)
  • ISBN 978-3-030-53820-0
  • Free shipping for individuals worldwide
  • Institutional customers should get in touch with their account manager
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  • Usually ready to be dispatched within 3 to 5 business days, if in stock
  • The final prices may differ from the prices shown due to specifics of VAT rules
Softcover 103,99 €
price for Spain (gross)
  • Due: October 13, 2021
  • ISBN 978-3-030-53823-1
  • Free shipping for individuals worldwide
  • Institutional customers should get in touch with their account manager
  • Shipping restrictions
  • The final prices may differ from the prices shown due to specifics of VAT rules
About this book

This book reviews the potential of next-generation sequencing (NGS) in research on and management of colorectal cancer (CRC), a leading cause of death worldwide and one of the most biologically and clinically heterogeneous cancers. It critically discusses findings from recent large-scale studies, clinical trials and meta-analyses and offers an introduction to the management of CRC in the era of precision medicine. In CRC, dozens of driver and passenger mutations are associated with the malignant transformation of epithelial cells. Consequently, the book discusses recent advances in our understanding of the genetics of CRC as a biomarker, the advent of NGS technologies in modern genomics, and the impact of NGS technology on the management of CRC. Furthermore, it highlights the potential of NGS in the context of liquid biopsy and single-cell sequencing in CRC, as well as its role in shedding light on the link between gut microbiota, immune-checkpoint blockade and CRC. The book concludes with a chapter on the limitations and cost-effectiveness of NGS in CRC.

Given its scope, the book will appeal to all those interested in learning about the potential of NGS in advancing CRC research and patient care. 

About the authors

Khalid El Bairi is the founder of The Cancer Biomarkers Working Group, and he is currently pursuing clinical and translational research in medical oncology. He has published many peer-reviewed articles in the field of predictive and prognostic cancer biomarkers to improve survival outcomes in several WoS and Medline-indexed journals. His research focuses particularly on biomarkers for digestive and gynecological cancers such as ovarian and colorectal malignancies. He is currently a member of the board of various international scientific societies such as the International Gynecologic Cancer Society (IGCS), European Society for Medical Oncology (ESMO), American Society of Clinical Oncology (ASCO), European Society of Gynaecological Oncology (ESGO), and the American Association for Cancer Research (AACR). He is also an editor and reviewer for more than 40 journals including BMC Cancer, PLoS ONE and Frontiers in Oncology and a guest editor for several special issues on gynecological cancers including Seminars in Cancer Biology and Current Drug Targets. He is also highly interested in teaching evidence-based medicine, clinical research methods, and publishing ethics to medical and Ph.D students and was selected for the 70th Lindau Nobel Laureate Meeting as a young scientist.

Table of contents (7 chapters)

Table of contents (7 chapters)
  • An Introduction to the Current Management of Colorectal Cancer in the Era of Personalized Oncology

    Pages 1-27

    Petrillo, Angelica (et al.)

  • Colorectal Cancer Genetics: An Overview of the Actionable Building Blocks

    Pages 29-71

    El Bairi, Khalid (et al.)

  • The Arrival of Next-Generation Sequencing: An Overview of Current Technologies

    Pages 73-89

    El Bairi, Khalid (et al.)

  • Next-Generation Sequencing for Colorectal Cancer Management

    Pages 91-110

    El Bairi, Khalid (et al.)

  • Gut Microbiota, Next-Generation Sequencing, Immune-Checkpoint Inhibitors, and Colorectal Cancer: How Hot Is the Link?

    Pages 111-145

    El Bairi, Khalid (et al.)

Buy this book

eBook 117,69 €
price for Spain (gross)
  • ISBN 978-3-030-53821-7
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover 145,59 €
price for Spain (gross)
  • ISBN 978-3-030-53820-0
  • Free shipping for individuals worldwide
  • Institutional customers should get in touch with their account manager
  • Shipping restrictions
  • Usually ready to be dispatched within 3 to 5 business days, if in stock
  • The final prices may differ from the prices shown due to specifics of VAT rules
Softcover 103,99 €
price for Spain (gross)
  • Due: October 13, 2021
  • ISBN 978-3-030-53823-1
  • Free shipping for individuals worldwide
  • Institutional customers should get in touch with their account manager
  • Shipping restrictions
  • The final prices may differ from the prices shown due to specifics of VAT rules
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Bibliographic Information

Bibliographic Information
Book Title
Illuminating Colorectal Cancer Genomics by Next-Generation Sequencing
Book Subtitle
A Big Chapter in the Tale
Editors
  • Khalid El Bairi
Copyright
2020
Publisher
Springer International Publishing
Copyright Holder
The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Switzerland AG
eBook ISBN
978-3-030-53821-7
DOI
10.1007/978-3-030-53821-7
Hardcover ISBN
978-3-030-53820-0
Softcover ISBN
978-3-030-53823-1
Edition Number
1
Number of Pages
XV, 185
Number of Illustrations
1 b/w illustrations, 25 illustrations in colour
Topics