Physiology in Health and Disease

Basic Epithelial Ion Transport Principles and Function

Ion Channels and Transporters of Epithelia in Health and Disease - Vol. 1

Editors: Hamilton, Kirk L., Devor, Daniel C. (Eds.)

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  • Offers a much more comprehensive second edition with several new chapters on various ion channels
    Builds a bridge between historical fundamentals and the latest advances in ion channel research
    Provides insights and methods from leading laboratories around the world

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eBook 93,08 €
price for Spain (gross)
  • ISBN 978-3-030-52780-8
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover 114,39 €
price for Spain (gross)
  • ISBN 978-3-030-52779-2
  • Free shipping for individuals worldwide
  • Institutional customers should get in touch with their account manager
  • Covid-19 shipping restrictions & severe weather in the US may cause delays
  • Usually ready to be dispatched within 3 to 5 business days, if in stock
  • The final prices may differ from the prices shown due to specifics of VAT rules
About this book

This book discusses unique ion channels and transporters that are located within epithelial tissues of various organs including the kidney, intestine, pancreas and respiratory tract. As the authors show, these channels and transporters play crucial roles in transepithelial ion and fluid transport across epithelia and their contribution to maintaining homeostasis. Readers will be introduced to the fundamentals of ion transport in terms of function, modelling, regulation, structure and pharmacology. This is the first of three volumes highlighting the importance of epithelial ion channels and transporters in basic physiology and pathophysiology of human diseases. 
This volume focuses  on basic fundamentals of epithelial transport physiology. There is a range of chapters dedicated to specific aspects of epithelial ion transport and cell function. Accordingly, the authors discuss techniques used to determine epithelial function, principles of epithelia transport, polarization of epithelial cells, mathematical modelling of epithelial ion transport, protein folding of ion channels, degradation epithelial ion channels, fundamentals of epithelial sodium, potassium and chloride transport, fundamentals of bicarbonate secretion, volume regulation, and microRNA regulation of epithelial channels and transporters. Given its scope, Volume 1 offers a valuable resource for physiology students, scientists and clinicians alike. 

About the authors

Kirk L. Hamilton was born in Baltimore, Maryland in 1953. He gained his undergraduate (biology/chemistry) and M.Sc. (ecology) degrees from the University of Texas at Arlington. He obtained his Ph.D. at Utah State University under the tutelage of Dr. James A. Gessaman, where he studied incubation physiology of Barn owls. His first post-doctoral position was at the University of Texas Medical Branch in Galveston, Texas under the mentorship of Dr. Douglas C. Eaton where he studied epithelial ion transport, specifically, the epithelial sodium channel (ENaC).  He then moved to the Department of Physiology at the University of Alabama, Birmingham for additional post-doctoral training under the supervision of the late Dr. Dale J. Benos where he further studied ENaC, and non-specific cation channels. He took his first academic post in the Department of Biology at Xavier University of Louisiana in New Orleans (1990-1994). He then joined the Department of Physiology at the University of Otago in 1994, and he is currently an Associate Professor. He has focused his research on the molecular physiology and trafficking of potassium channels (specifically KCa3.1). He has published more than 60 papers and book chapters. His research work has been funded by the NIH, American Heart Association, Cystic Fibrosis Foundation, and Lottery Health Board New Zealand. Dr. Devor and he have been collaborators since 1999. When he not working, he enjoys playing guitar (blues and jazz) and volleyball. Kirk is married to Judith Rodda, a recent Ph.D. graduate in spatial ecology. They have 2 children, Nathan (b. 1995) and Emma (b. 1998).

Daniel C. Devor was born in Vandercook Lake, Michigan in 1961. His education took him through Southampton College of Long Island University, where he studied Marine Biology, before entering SUNY Buffalo for his Ph.D., under the guidance of Dr. Michael E. Duffey. During this time, he studied the role of basolateral potassium channels in regulating transepithelial ion transport. He subsequently did his post-doctoral work at the University of Alabama, Birmingham, under the mentorship of Dr. Raymond A. Frizzell, where he studied both apical CFTR and basolateral KCa3.1 in intestinal and airway epithelia. He joined the University of Pittsburgh faculty in 1995 where he is currently a Professor of Cell Biology. During this time, he has continued to study the regulation, gating and trafficking of KCa3.1 as well as the related family member, KCa2.3, publishing more than 50 papers on these topics. These studies have been funded by the NIH, Cystic Fibrosis Foundation, American Heart Association and pharmaceutical industry. When not in the lab, he enjoys photography and growing exotic plants. Dan is married to Catherine Seluga, an elementary school teacher. They have 3 children, Caitlin (b. 1990), Emily (b. 1993) and Daniel (b. 1997).

Table of contents (13 chapters)

Table of contents (13 chapters)

Buy this book

eBook 93,08 €
price for Spain (gross)
  • ISBN 978-3-030-52780-8
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover 114,39 €
price for Spain (gross)
  • ISBN 978-3-030-52779-2
  • Free shipping for individuals worldwide
  • Institutional customers should get in touch with their account manager
  • Covid-19 shipping restrictions & severe weather in the US may cause delays
  • Usually ready to be dispatched within 3 to 5 business days, if in stock
  • The final prices may differ from the prices shown due to specifics of VAT rules
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Bibliographic Information

Bibliographic Information
Book Title
Basic Epithelial Ion Transport Principles and Function
Book Subtitle
Ion Channels and Transporters of Epithelia in Health and Disease - Vol. 1
Editors
  • Kirk L. Hamilton
  • Daniel C. Devor
Series Title
Physiology in Health and Disease
Copyright
2020
Publisher
Springer International Publishing
Copyright Holder
The American Physiological Society
eBook ISBN
978-3-030-52780-8
DOI
10.1007/978-3-030-52780-8
Hardcover ISBN
978-3-030-52779-2
Series ISSN
2625-252X
Edition Number
2
Number of Pages
XIX, 563
Number of Illustrations
35 b/w illustrations, 71 illustrations in colour
Topics