cover

Mechanisms of Gene Regulation: How Science Works

Authors: Carlberg, Carsten, Molnár, Ferdinand

  • Includes a high figure to text ratio to improve learningBased of 18 years teaching experience on the topicProvides in a condensed form an overview on the present understanding of the mechanisms of gene regulation

Buy this book

eBook 50,28 €
price for Spain (gross)
  • Due: December 12, 2020
  • ISBN 978-3-030-52321-3
  • Digitally watermarked, DRM-free
  • Included format:
  • Immediate eBook download after purchase and usable on all devices
Softcover 62,39 €
price for Spain (gross)
About this Textbook

This textbook aims to describe the fascinating area of eukaryotic gene regulation for graduate students in all areas of the biomedical sciences. Gene expression is essential in shaping the various phenotypes of cells and tissues and as such, regulation of gene expression is a fundamental aspect of nearly all processes in physiology, both in healthy and in diseased states. Th is pivotal role for the regulation of gene expression makes this textbook essential reading for students of all the biomedical sciences, in order to be better prepared for their specialized disciplines. A complete understanding of transcription factors and the processes that alter their activity is a major goal of modern life science research. The availability of the whole human genome sequence (and that of other eukaryotic genomes) and the consequent development of next-generation sequencing technologies have significantly changed nearly all areas of the biological sciences. For example, the genome-wide location of histone modifications and transcription factor binding sites, such as provided by the ENCODE consortium, has greatly improved our understanding of gene regulation. Therefore, the focus of this book is the description of the post-genome understanding of gene regulation.

About the authors

Carsten Carlberg graduated 1989 with a PhD in biochemistry at the Free University Berlin (Germany). After positions as postdoc at Roche (Basel, Switzerland), group leader at the University of Geneva (Switzerland) and docent at the University of Düsseldorf (Germany) he is since 2000 full professor of biochemistry at the University of Eastern Finland in Kuopio (Finland). His work focuses on mechanisms of gene regulation by nuclear hormones, in particular on vitamin D. At present Prof. Carlberg focuses projects on epigenome-wide effects of vitamin D on the human immune system.

 

Ferdinand Molnár received his PhD in biochemistry from the University of Kuopio (Kuopio, Finland) in 2006. He did his postdoctoral training in Structural Biology at the IGBMC (Illkirch, France). In 2008 he joined the School of Pharmacy at the University of Eastern Finland (Kuopio, Finland) studying nuclear receptor-ligand, - protein and -DNA interactions. In 2018 he moved to the Nazarbayev University (Nur-Sultan, Kazakhstan) where he holds an Associate Professor position at the Department of Biology. Prof. Molnár interests are integrative structural biology and bioinformatics, eukaryotic transcriptional regulation in health and disease and recombinant protein production.

Table of contents (9 chapters)

Table of contents (9 chapters)
  • Genes and Chromatin

    Pages 1-17

    Carlberg, Carsten (et al.)

  • Basal Transcriptional Machinery

    Pages 19-33

    Carlberg, Carsten (et al.)

  • Transcription Factors and Signal Transduction

    Pages 35-57

    Carlberg, Carsten (et al.)

  • A Key Transcription Factor Family: Nuclear Receptors

    Pages 59-70

    Carlberg, Carsten (et al.)

  • Genome-Wide Principles of Gene Regulation

    Pages 71-82

    Carlberg, Carsten (et al.)

Buy this book

eBook 50,28 €
price for Spain (gross)
  • Due: December 12, 2020
  • ISBN 978-3-030-52321-3
  • Digitally watermarked, DRM-free
  • Included format:
  • Immediate eBook download after purchase and usable on all devices
Softcover 62,39 €
price for Spain (gross)
Loading...

Recommended for you

Loading...

Bibliographic Information

Bibliographic Information
Book Title
Mechanisms of Gene Regulation: How Science Works
Authors
Copyright
2020
Publisher
Springer International Publishing
Copyright Holder
Springer Nature Switzerland AG
eBook ISBN
978-3-030-52321-3
DOI
10.1007/978-3-030-52321-3
Softcover ISBN
978-3-030-52320-6
Edition Number
1
Number of Pages
XVI, 149
Number of Illustrations
1 b/w illustrations, 70 illustrations in colour
Topics