Advances in Anatomy, Embryology and Cell Biology

Animal Models for Endometriosis

Evolution, Utility and Clinical Relevance

Editors: Sharpe-Timms, Kathy L. (Ed.)

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  • Explores the use of animal models for endometriosis research
  • Provides insights into disease-associated subfertility and pain
  • Elaborates on the role of endocrine disrupters and miRNA
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eBook 74,89 €
price for Spain (gross)
  • ISBN 978-3-030-51856-1
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Softcover 93,59 €
price for Spain (gross)
  • ISBN 978-3-030-51855-4
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  • Usually ready to be dispatched within 3 to 5 business days, if in stock
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About this book

This new volume of our successful book series Advances in Anatomy, Embryology and Cell Biology focuses on the need for and use of animal models when studying endometriosis. Covering models ranging from rodents to baboons, it explores novel mechanisms involved in the pathophysiology of endometriosis. Topics range from the role of miRNAs and environmental endocrine disrupters to pain and endometriosis-associated subfertility.

Estimated to affect up to 10% of women, endometriosis is a widespread and in some cases debilitating disease. While studies on the pathophysiology of the disease and the development of treatments for endometriosis-associated subfertility are called for, acquiring appropriate tissues from women with and without endometriosis in combination with physiologically relevant in vitro and in vivo laboratory models is an essential aspect. However, control subjects with similar ages, living environments and medical histories, besides endometriosis, are hard to find and attaining suitable human reproductive tissues is linked to an ongoing ethical discussion, especially when studying embryos. Laboratory models like rodent and monkey models are therefore needed to fill the research gap and support hypothesis-driven, randomized, controlled experimental design studies. In this book we highlight the latest developments and findings in endometriosis research using animal models.

The book was written for scientists, physicians and medical students working in the field of reproductive science, and for women with endometriosis.

About the authors

Dr. Sharpe-Timms received her Ph.D. in Reproductive Pathophysiology from the University of Tennessee and completed a postdoctoral fellowship at the University of Kentucky. She served at the Department of Obstetrics, Gynecology and Women’s Health at the University of Missouri (MU) for over 30 years, advancing to Full Professor. Her research has identified proteins synthesized and secreted by endometriotic lesions, first in a rat model and later reproducing these results in women with endometriosis. She has also identified transgenerational subfertility in three generations of offspring using a rat model for endometriosis. Primarily funded by the National Institutes of Health, Dr. Sharpe-Timms’ endometriosis research has led to over 185 publications, abstracts, and invited oral presentations at national and international meetings. She retired from MU in 2019, now serving as Professor Emerita and collaborating with colleagues.


Table of contents (6 chapters)

Table of contents (6 chapters)
  • Introduction to Preclinical Evidence from Animal Models of Endometriosis

    Pages 1-8

    Sharpe-Timms, Kathy L. (et al.)

  • Identifying Mechanisms of Endometriosis-Associated Reduced Fecundity in a Rat Model: Novel Insights toward Understanding Human Infertility

    Pages 9-24

    Sharpe-Timms, Kathy L. (et al.)

  • Endometriosis-Associated Pain – Do Preclinical Rodent Models Provide a Good Platform for Translation?

    Pages 25-55

    Greaves, Erin (et al.)

  • Environmental Endocrine Disruptors and Endometriosis

    Pages 57-78

    Rumph, Jelonia T. (et al.)

  • Deciphering the Role of miRNAs in Endometriosis Pathophysiology Using Experimental Endometriosis Mouse Models

    Pages 79-97

    Vashisht, Ayushi (et al.)

Buy this book

eBook 74,89 €
price for Spain (gross)
  • ISBN 978-3-030-51856-1
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Softcover 93,59 €
price for Spain (gross)
  • ISBN 978-3-030-51855-4
  • Free shipping for individuals worldwide
  • Institutional customers should get in touch with their account manager
  • Shipping restrictions
  • Usually ready to be dispatched within 3 to 5 business days, if in stock
  • The final prices may differ from the prices shown due to specifics of VAT rules
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Bibliographic Information

Bibliographic Information
Book Title
Animal Models for Endometriosis
Book Subtitle
Evolution, Utility and Clinical Relevance
Editors
  • Kathy L. Sharpe-Timms
Series Title
Advances in Anatomy, Embryology and Cell Biology
Series Volume
232
Copyright
2020
Publisher
Springer International Publishing
Copyright Holder
Springer Nature Switzerland AG
eBook ISBN
978-3-030-51856-1
DOI
10.1007/978-3-030-51856-1
Softcover ISBN
978-3-030-51855-4
Series ISSN
0301-5556
Edition Number
1
Number of Pages
VII, 111
Number of Illustrations
4 b/w illustrations, 8 illustrations in colour
Topics