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Progress in Inflammation Research

The M2 Macrophage

Authors: Röszer, Tamás

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  • Provides a comprehensive summary of M2 macrophage functions
  • Fills an important gap in the literature on leukocyte biology
  • Can be used as a textbook or reference guide
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eBook 106,99 €
price for Spain (gross)
  • ISBN 978-3-030-50480-9
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Hardcover 135,19 €
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About this book

Macrophages are core components of the innate immune system. Once activated, they may have either pro- or anti-inflammatory effects that include pathogen killing, safe disposal of apoptotic cells or tissue renewal. The activation state of macrophages is conceptualized by the so-called M1/M2 model of polarization. M2 macrophages are not simply antagonists of M1 macrophages; rather, they represent a network of tissue resident macrophages with roles in tissue development and organ homeostasis. M2 macrophages govern functions at the interfaces of immunity, tissue development and turnover, metabolism, and endocrine signaling. Dysfunction in M2 macrophages can ruin the healthy interplay between the immune system and metabolic processes, and lead to diseases such as insulin resistance, metabolic syndrome, and type 1 and 2 diabetes mellitus. Furthermore, M2 macrophages are essential for healthy tissue development and immunological self-tolerance. Worryingly, these functions of M2 macrophages can also be disrupted, resulting in tumor growth and autoimmunity. This book comprehensively discusses the biology of M2 macrophages, summarizes the current state of knowledge, and highlights key questions that remain unanswered.

About the authors

Tamás Röszer is a Research Group Leader and Lecturer (Privatdozent) at the Institute of Neurobiology, Ulm University, Germany. His chief research interests are the endocrine control of immunity and metabolism, and macrophage biology in the context of development and physiology. He is the author of several research articles in the field of immunometabolism, diabetes and comparative molecular endocrinology, and reference books in nitric oxide biology and pathophysiology.

Table of contents (11 chapters)

Table of contents (11 chapters)

Buy this book

eBook 106,99 €
price for Spain (gross)
  • ISBN 978-3-030-50480-9
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover 135,19 €
price for Spain (gross)
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Bibliographic Information

Bibliographic Information
Book Title
The M2 Macrophage
Authors
Series Title
Progress in Inflammation Research
Series Volume
86
Copyright
2020
Publisher
Springer International Publishing
Copyright Holder
Springer Nature Switzerland AG
eBook ISBN
978-3-030-50480-9
DOI
10.1007/978-3-030-50480-9
Hardcover ISBN
978-3-030-50479-3
Series ISSN
0379-0363
Edition Number
1
Number of Pages
XIII, 224
Number of Illustrations
7 b/w illustrations, 49 illustrations in colour
Topics