Translational Pancreatic Cancer Research

1. Front Matter

   Pages i-xii

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2. PDAC Variants and Risk of Disease

   1. Front Matter

      Pages 1-1

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   2. Subtypes of Pancreatic Adenocarcinoma

      • Luisa Ingenhoff, Lena Häberle, Irene Esposito

      Pages 3-16

3. PDAC Precursors and Early Diagnosis

   1. Front Matter

      Pages 17-17

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   2. Surveillance and Intervention in IPMN

      • A. Balduzzi, N. C. M. van Huijgevoort, G. Marchegiani, M. Engelbrecht, J. Stoker, J. Verheij et al.

      Pages 19-36

   3. Novel Biomarkers of Invasive IPMN

      • Stephen Hasak, Koushik K. Das

      Pages 37-70

4. Diagnosis, Biomarkers and Stratification

   1. Front Matter

      Pages 71-71

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   2. Challenges and Opportunities for Early Pancreatic Cancer Detection: Role for Protein Biomarkers

      • Lucy Oldfield, Lawrence Barrera, Dylan Williams, Anthony E. Evans, John Neoptolemos, Eithne Costello

      Pages 73-82

   3. Metabolic Biomarkers of Pancreatic Cancer

      • Ujjwal Mukund Mahajan, Qi Li, Beate Kamlage, Markus M. Lerch, Julia Mayerle

      Pages 83-96

   4. Blood-Based Circulating RNAs as Preventive, Diagnostic, Prognostic and Druggable Biomarkers for Pancreatic Ductal Adenocarcinoma

      • Bo Kong, Helmut Friess

      Pages 97-106

   5. Circulating Tumor DNA as a Novel Biomarker for Pancreatic Cancer

      • Andreas W. Berger, Alexander Kleger

      Pages 107-116

   6. PDAC Subtypes/Stratification

      • Holly Brunton, Giuseppina Caligiuri, Gareth J. Inman, Peter Bailey

      Pages 117-128

   7. Circulating Tumor Cells as Biomarkers in Pancreatic Cancer

      • Alina Hasanain, Christopher L. Wolfgang

      Pages 129-143

5. Personalized Treatment Approaches

   1. Front Matter

      Pages 145-145

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   2. Personalized Models of Human PDAC

      • Hanna Heikenwälder, Susanne Roth

      Pages 147-156

   3. Therapeutic Targeting of Stromal Components

      • Albrecht Neesse

      Pages 157-168

   4. Epigenetic Targeting

      • Svenja Pichlmeier, Ivonne Regel

      Pages 169-182

   5. Targeting Metabolism

      • Yoshiaki Sunami

      Pages 183-202

   6. Targeting the Immune System in Pancreatic Cancer

      • D. Kabacaoglu, D. A. Ruess, Hana Algül

      Pages 203-218

   7. Phase I Trials in Pancreatic Cancer

      • Thomas Seufferlein, Angelika Kestler, Alica Beutel, Lukas Perkhofer, Thomas Ettrich

      Pages 219-232

​This book incorporates a multi-disciplinary approach to present how research results can be translated into clinical trials. The first part begins with a chapter on variants of pancreatic cancer, precursor lesions and groups of people at risk to developing the disease. There is a particular focus on intraductal papillary mucinous neoplasia as a large-scale clinical challenge in pancreatology. The next two parts focus on diagnosis, biomarkers and stratification that emphasize how various approaches to biomarker development are important as both prognostic and predictive tools. The final part consists of personalized treatment approaches that include preclinical models of pancreatic cancer and stromal, epigenetic and metabolism targeting as promising approaches to be translated into early phase clinical trials. Chapters within this part also deal with approaches that are close to being implemented in clinical practice or are already being tested in (early) clinical trials, such asthose that targeting the immune systems and strategies to overcome immunotherapy resistance; phase 1 clinical trials and translational approaches in surgical treatment. 


Written by experts in their fields, Translational Pancreatic Cancer Research provides an outlook towards future directions by integrating information both from basic and clinical research and though demonstrating pathways to better understanding pancreatic cancer and current approaches to translating these into clinical practice.

• PDAC PRECURSORS
• BIOMARKERS AND STRATIFICATION
• PERSONALIZED TREATMENT
• Epigenetic targeting
• Molecular imaging

• Department of Visceral, Vascular and Endocrine Surgery, University Hospital Halle (Saale), Halle (Saale), Germany

  Christoph W. Michalski, Jörg Kleeff

• Department of Internal Medicine I, University Hospital Halle (Saale), Halle (Saale), Germany

  Jonas Rosendahl, Patrick Michl

Christoph W. Michalski
Department of Visceral, Vascular und Endocrine Surgery
University Hospital Halle (Saale)
Halle (Saale), Germany


Jonas Rosendahl
Department of Internal Medicine I
University Hospital Halle (Saale)
Halle (Saale), Germany


Patrick Michl
Department of Internal Medicine I
University Hospital Halle (Saale)
Halle (Saale), Germany


Jörg Kleeff
Department of Visceral, Vascular und Endocrine Surgery
University Hospital Halle (Saale)
Halle (Saale), Germany

Policies and ethics