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Clinical Xenotransplantation

Pathways and Progress in the Transplantation of Organs and Tissues Between Species

Editors: Cooper, David K. C., Byrne, Guerard (Eds.)

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  • First title of its kind that provides up-to-date information on the planning and preparation that goes toward clinical xenotransplantation
  • Features an authorship consisting of several leaders in the field of clinical organ transplantation as well as the leaders in the field of xenotransplantation research
  • Reviews and analyzes the research that has provided the recent experimental advances within the field
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eBook 109,99 €
price for Spain (gross)
  • ISBN 978-3-030-49127-7
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  • Immediate eBook download after purchase
Hardcover 145,59 €
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About this book

This title provides an illuminating examination of the current state of xenotransplantation – grafting or transplanting organs or tissues between members of different species – and how it might move forward into the clinic. To be sure, this is a critical topic, as a major problem that remains worldwide is an inadequate supply of organs from deceased human donors, severely limiting the number of organ transplants that can be performed each year.  Based on presentations given at a major conference on xenotransplantation, this title includes important views from many leading experts who were invited to present their data and opinions on how xenotransplantation can advance into the clinic. Attention was concentrated on pig kidney and heart transplantation as it is in regard to these organs that most progress has been made.  Collectively, these chapters effectively highlight the many advantages of xenotransplantation to patients with end-stage organ failure, thereby encouraging the mapping of a concrete pathway to clinical xenotransplantation.  
The book is organized across 22 chapters, beginning with background information on clinical and experimental xenotransplantation. Following this are discussions addressing how pigs can be genetically engineered for their organs to be resistant to the human immune response through deletion of pig xenoantigens, and the insertion of ‘protective’ human transgenes. Subsequent chapters analyze complications that arise in practice, comparing allotransplant and xenotransplant rejection. The selection of the ideal patients for the first clinical trials is discussed. Finally, the book concludes with an analysis on the regulatory, economic, and social aspects of this research, including FDA perspectives and the sensitive, psychosocial factors regarding allotransplantation and xenotransplantation. 
A major and timely addition to the literature, Clinical Xenotransplantation will be of great interest to all researchers, physicians, and academics from other disciplines with an interest in xenotransplantation.

About the authors

David K.C. Cooper MD, PhD, FRCSUniversity of Alabama at Birmingham (UAB)Co-Director, Xenotransplantation ProgramDepartment of SurgeryBirmingham, AL 
Guerard W. Byrne, PhDDepartment of SurgeryUniversity of Alabama at BirminghamBirmingham, ALUSA

Table of contents (22 chapters)

Table of contents (22 chapters)

Buy this book

eBook 109,99 €
price for Spain (gross)
  • ISBN 978-3-030-49127-7
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover 145,59 €
price for Spain (gross)
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Bibliographic Information

Bibliographic Information
Book Title
Clinical Xenotransplantation
Book Subtitle
Pathways and Progress in the Transplantation of Organs and Tissues Between Species
Editors
  • David K. C. Cooper
  • Guerard Byrne
Copyright
2020
Publisher
Springer International Publishing
Copyright Holder
Springer Nature Switzerland AG
eBook ISBN
978-3-030-49127-7
DOI
10.1007/978-3-030-49127-7
Hardcover ISBN
978-3-030-49126-0
Edition Number
1
Number of Pages
XXIX, 306
Number of Illustrations
23 b/w illustrations, 59 illustrations in colour
Topics

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