Topics in Medicinal Chemistry

Chemical Epigenetics

Editors: Mai, Antonello (Ed.)

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  • Offers a comprehensive review of the chemical mechanisms involved in epigenetics
  • Covers the significant findings about epigenetic targets
  • Explores the design, synthesis and biological validation of epigenetic chemical modulators
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eBook 160,49 €
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  • ISBN 978-3-030-42982-9
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Hardcover 291,19 €
price for Spain (gross)
  • ISBN 978-3-030-42981-2
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Softcover 207,99 €
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  • ISBN 978-3-030-42984-3
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About this book

This book presents an authoritative review of the most significant findings about all the epigenetic targets (writers, readers, and erasers) and their implication in physiology and pathology. The book also covers the design, synthesis and biological validation of epigenetic chemical modulators, which can be useful as novel chemotherapeutic agents. Particular attention is given to the chemical mechanisms of action of these molecules and to the drug discovery prose which allows their identification.

This book will appeal to students who want to know the extensive progresses made by epigenetics (targets and modulators) in the last years from the beginning, and to specialized scientists who need an instrument to quickly search and check historical and/or updated notices about epigenetics. 

About the authors

Antonello Mai is a Full Professor of Medicinal Chemistry at the Faculty of Pharmacy and Medicine, Sapienza University of Rome, since 2011. He completed his Pharmacy degree in 1984, and his PhD in Medicinal Chemistry and Pharmaceutical Sciences in 1992, both at Sapienza. In 1998 he was appointed as Associate Professor of Medicinal Chemistry at Sapienza’s Faculty of Pharmacy. From 2012 to 2018 he was the Coordinator of the PhD Course in Pharmaceutical Science, and from 2013 to 2019 he was President of the Degree Course in Pharmaceutical Chemistry and Technologies.

From 2004 to 2009, Prof. Mai was a member of the Executive Committee of the Medicinal Chemistry Division of the Italian Chemical Society, and from 2009 to 2014 he was a member of the Scientific Committee of the European School of Medicinal Chemistry. He is an Editor of the journal ChemMedChem (Wiley), Regional Editor of Mini Reviews in Medicinal Chemistry and Medicinal Chemistry (Bentham), and Associate Editor of Clinical Epigenetics (Springer) and the Journal of Enzyme Inhibition and Medicinal Chemistry (Taylor and Francis).

His career has largely focused on the synthesis of new potential bioactive compounds, particularly in the field of epigenetics (since 1999: inhibitors of HDACs, HATs, sirtuins, PRMTs, HKMTs, KDMs and DNMTs). Prof. Mai is the author of more than 280 publications in high-impact international journals [h-index = 52] and three book chapters.

Table of contents (16 chapters)

Table of contents (16 chapters)

Buy this book

eBook 160,49 €
price for Spain (gross)
  • ISBN 978-3-030-42982-9
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover 291,19 €
price for Spain (gross)
  • ISBN 978-3-030-42981-2
  • Free shipping for individuals worldwide
  • Institutional customers should get in touch with their account manager
  • Shipping restrictions
  • Usually ready to be dispatched within 3 to 5 business days, if in stock
  • The final prices may differ from the prices shown due to specifics of VAT rules
Softcover 207,99 €
price for Spain (gross)
  • ISBN 978-3-030-42984-3
  • Free shipping for individuals worldwide
  • Institutional customers should get in touch with their account manager
  • Shipping restrictions
  • Usually ready to be dispatched within 3 to 5 business days, if in stock
  • The final prices may differ from the prices shown due to specifics of VAT rules
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Bibliographic Information

Bibliographic Information
Book Title
Chemical Epigenetics
Editors
  • Antonello Mai
Series Title
Topics in Medicinal Chemistry
Series Volume
33
Copyright
2020
Publisher
Springer International Publishing
Copyright Holder
Springer Nature Switzerland AG
eBook ISBN
978-3-030-42982-9
DOI
10.1007/978-3-030-42982-9
Hardcover ISBN
978-3-030-42981-2
Softcover ISBN
978-3-030-42984-3
Series ISSN
1862-2461
Edition Number
1
Number of Pages
IX, 567
Number of Illustrations
30 b/w illustrations, 50 illustrations in colour
Topics