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Clinical Genetics and Genomics of Aging

  • Book
  • © 2020

Overview

Editors:
  1. Juan Carlos Gomez-Verjan

    1. Basic Sciencies Division, National Institute of Geriatrics, Ciudad de México, Mexico

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    You can also search for this editor in PubMed   Google Scholar

  2. Nadia Alejandra Rivero-Segura

    1. Instituto Nacional de Geriatría (INGER), Ciudad de México, Mexico

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

  • Moves from the molecular pillars of aging to a perspective of the pharmacological, clinical and diagnostic applications using genetic approaches and techniques

  • Adopts the perspective of geroscience, which seeks to understand the genetic, molecular and cellular mechanisms of aging

  • Makes a significant contribution to support aging research as move and move people benefit from increased longevity

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Table of contents (13 chapters)

  1. Front Matter

    Pages i-xv
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  2. An Update on the Molecular Pillars of Aging

    • Lizbeth García-Velázquez, Clorinda Arias
    Pages 1-25

  3. Age-Related Neurodegenerative Diseases: An Update

    • Nadia Alejandra Rivero-Segura, A. A. Guerrero-Cruz, O. S. Barrera-Vázquez
    Pages 27-41

  4. Molecular Aspects of Hippocampal Aging

    • Mariana Temido-Ferreira, Luísa V. Lopes
    Pages 43-63

  5. Mitochondrial Function in Aging

    • S. L. Morales-Rosales, Nadia Alejandra Rivero-Segura, M. Königsberg
    Pages 65-85

  6. Genomic Tools Used in Molecular Clinical Aging Research

    • Alfredo García-Venzor, Edna Ayerim Mandujano-Tinoco
    Pages 87-109

  7. Molecular Biomarkers of Aging Studies in Humans

    • G. Pedraza-Vázquez, A. Alarcón-Aguilar, A. Luna-López
    Pages 111-123

  8. Alternative Splicing and Aging

    • J. C. Yustis-Rubio, Juan Carlos Gomez-Verjan
    Pages 125-139

  9. Epigenetics and Ageing

    • Nancy Monroy-Jaramillo, Edgar Ricardo Vázquez-Martínez
    Pages 141-166

  10. Microbiome Research and Aging

    • B. P. Chávez-Elizalde, O. S. Barrera-Vázquez, M. F. Carrillo-Vega
    Pages 167-185

  11. Molecular Basis of Progeroid Diseases

    • Ian García-Aguirre, Feliciano Monterrubio-Ledezma, Alma Alamillo-Iniesta, Susana Castro-Obregón, Bulmaro Cisneros
    Pages 187-211

  12. Applications of CRISPR-Cas in Ageing Research

    • Scott Haston, Sara Pozzi, Jose Mario Gonzalez-Meljem
    Pages 213-230

  13. Pharmacological Treatment for Aging: Are We There?

    • O. S. Barrera-Vázquez, Juan Carlos Gomez-Verjan
    Pages 231-245

  14. Integrative Outlooks About Clinical and Biomedical Research in Ageing

    • C. García-Peña, Raúl Medina-Campos, E. Delgado-de Anda, O. S. Barrera-Vázquez
    Pages 247-264

  15. Back Matter

    Pages 265-271
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Keywords

About this book

The world population is rapidly aging—it is estimated that by 1950, around 17% of the population will be elderly. In this context, aging involves several physiological, psychological and highly complex social processes that vary from one person to another. For a long time, medical care for older adults has focused on treating chronic, age-related diseases and their associated consequences. Recently, biomedical research brings a novel point of view to develop more effective interventions by targeting the aging process itself rather than separate conditions. There is a growing number of reports indicating that aging is driven by several interconnected mechanisms and biological components referred to as the molecular pillars of aging. Interfering with these mechanisms could help to treat, prevent, and understand the development of age-related diseases and associated syndromes. This book provides a clinical perspective and general update on biomedical and genetic research in aging, moving from an update in the molecular pillars of aging to a perspective of the most recent pharmacological, clinical, and diagnostic applications using genomic approaches and techniques. While this book focuses on the specifics of genetics and genomics, it also adopts a clinical perspective of geroscience, which seeks to understand the genetic, molecular and cellular mechanisms that make aging an important risk factor and, sometimes, a determining factor in the diseases and common chronic conditions of older people. Additionally, Clinical Genetics and Genomics of Aging is a significant contribution to support aging research, as it shows that collaboration across disciplines is relevant to progress in the field. As more and more people benefit from increased longevity, clinician and researchers will be empowered by this knowledge to contribute to the progress of aging research. 

Editors and Affiliations

  • Basic Sciencies Division, National Institute of Geriatrics, Ciudad de México, Mexico

    Juan Carlos Gomez-Verjan

  • Instituto Nacional de Geriatría (INGER), Ciudad de México, Mexico

    Nadia Alejandra Rivero-Segura

About the editors

Juan Carlos Gomez-Verjan, PhD
Basic Sciences Division
National Institute of Geriatrics
Mexico City, Mexico 

Nadia Alejandra Rivero-Segura, PhD
Basic Sciences Division
National Institute of Geriatrics
Mexico City, Mexico

Bibliographic Information

  • Book Title: Clinical Genetics and Genomics of Aging

  • Editors: Juan Carlos Gomez-Verjan, Nadia Alejandra Rivero-Segura

  • DOI: https://doi.org/10.1007/978-3-030-40955-5

  • Publisher: Springer Cham

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: Springer Nature Switzerland AG 2020

  • Hardcover ISBN: 978-3-030-40954-8Published: 14 April 2020

  • Softcover ISBN: 978-3-030-40957-9Published: 14 April 2021

  • eBook ISBN: 978-3-030-40955-5Published: 13 April 2020

  • Edition Number: 1

  • Number of Pages: XV, 271

  • Number of Illustrations: 1 b/w illustrations, 11 illustrations in colour

  • Topics: Human Genetics

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