Advances in Experimental Medicine and Biology

Tumor Microenvironment

The Main Driver of Metabolic Adaptation

Editors: Serpa, Jacinta (Ed.)

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  • An integrative view of tumor microenvironment and cancer metabolic adaptations, focusing different cancer contexts and interspecific cellular actions
  • A wide range of traits, showing the way cancer adapts metabolically to the microenvironment
  • A clear presentation of different cancer models and analytical techniques, their usefulness, advantages and limitations
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eBook 128,39 €
price for Spain (gross)
  • ISBN 978-3-030-34025-4
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Hardcover 166,39 €
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About this book

The way a cell undergoes malignant transformation should meet their capacity of surviving in the microenvironment of the organ where the cancer will develop. Metabolic adaptation is for sure one of the criteria that must be accomplished, driven by metabolic plasticity that allows the adaptation of cancer cells to the availability of energy and biomass sources that will sustain cell survival and proliferation. Each human organ has a particular microenvironment which depends on several cell types and in some cases also on symbiotic microorganisms. These biological partners are constantly sharing organic compounds and signaling molecules that will control mitogenesis, cell death and differentiation, accounting for the organ's function. Nevertheless, cancer cells are capable of taking advantage of this metabolic and signaling microenvironmental dynamics.

In this book, we intend to present the different components of the microenvironment driving the metabolic fitness of cancer cells. The metabolic changes required for establishing a tumor in a given microenvironment and how these metabolic changes limit the response to drugs will generally be the major items addressed. It is important to mention not only aspects of the microenvironment that stimulate metabolic changes and that select better adapted tumor cells, but also how this regulation of cell plasticity is made. Thus, the signaling pathways that orchestrate and are orchestrated throughout this panoply of metabolic rearrangements will also be addressed in this book.

The subjects will be presented from the conceptual point of view of the cross-cancer mechanisms and also particularizing some models that can be examples and enlightening within the different areas.

About the authors

Jacinta Serpa is an Assistant Professor and Senior Researcher at the Universidade Nova de Lisboa. 

Table of contents (23 chapters)

Table of contents (23 chapters)
  • Metabolic Remodeling as a Way of Adapting to Tumor Microenvironment (TME), a Job of Several Holders

    Pages 1-34

    Serpa, Jacinta

  • Tumor Microenvironment – Selective Pressures Boosting Cancer Progression

    Pages 35-49

    Nunes, Sofia C.

  • Lactate and Lactate Transporters as Key Players in the Maintenance of the Warburg Effect

    Pages 51-74

    Pereira-Nunes, Andreia (et al.)

  • Recycling the Interspecific Relations with Epithelial Cells: Bacteria and Cancer Metabolic Symbiosis

    Pages 77-91

    Nunes, Sofia C. (et al.)

  • Gut Microbiota and Cancer of the Host: Colliding Interests

    Pages 93-107

    Baffy, Gyorgy

Buy this book

eBook 128,39 €
price for Spain (gross)
  • ISBN 978-3-030-34025-4
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover 166,39 €
price for Spain (gross)
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Bibliographic Information

Bibliographic Information
Book Title
Tumor Microenvironment
Book Subtitle
The Main Driver of Metabolic Adaptation
Editors
  • Jacinta Serpa
Series Title
Advances in Experimental Medicine and Biology
Series Volume
1219
Copyright
2020
Publisher
Springer International Publishing
Copyright Holder
Springer Nature Switzerland AG
eBook ISBN
978-3-030-34025-4
DOI
10.1007/978-3-030-34025-4
Hardcover ISBN
978-3-030-34024-7
Series ISSN
0065-2598
Edition Number
1
Number of Pages
VII, 443
Number of Illustrations
2 b/w illustrations, 61 illustrations in colour
Topics