The Biology of mRNA: Structure and Function

1. Front Matter

   Pages i-viii

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2. Mechanism and Regulation of Co-transcriptional mRNP Assembly and Nuclear mRNA Export

   • Wolfgang Wende, Peter Friedhoff, Katja Sträßer

   Pages 1-31

3. It’s Not the Destination, It’s the Journey: Heterogeneity in mRNA Export Mechanisms

   • Daniel D. Scott, L. Carolina Aguilar, Mathew Kramar, Marlene Oeffinger

   Pages 33-81

4. View from an mRNP: The Roles of SR Proteins in Assembly, Maturation and Turnover

   • Marius Wegener, Michaela Müller-McNicoll

   Pages 83-112

5. The Nuclear RNA Exosome and Its Cofactors

   • Manfred Schmid, Torben Heick Jensen

   Pages 113-132

6. 3′-UTRs and the Control of Protein Expression in Space and Time

   • Traude H. Beilharz, Michael M. See, Peter R. Boag

   Pages 133-148

7. Communication Is Key: 5′–3′ Interactions that Regulate mRNA Translation and Turnover

   • Hana Fakim, Marc R. Fabian

   Pages 149-164

8. Bioinformatics Approaches to Gain Insights into cis-Regulatory Motifs Involved in mRNA Localization

   • Louis Philip Benoit Bouvrette, Mathieu Blanchette, Eric Lécuyer

   Pages 165-194

9. RNA Granules and Their Role in Neurodegenerative Diseases

   • Hadjara Sidibé, Christine Vande Velde

   Pages 195-245

10. Lessons from (pre-)mRNA Imaging

    • Srivathsan Adivarahan, Daniel Zenklusen

    Pages 247-284

11. Diverging RNPs: Toward Understanding lncRNA-Protein Interactions and Functions

    • Martin Sauvageau

    Pages 285-312

The book provides an overview on the different aspects of gene regulation from an mRNA centric viewpoint, including how mRNA is assembled and self-assembles in a complex consisting of RNA and proteins, and how its ability to be translated at the right time and space depends on many processes acting on the mRNAs, leading to a properly folded complex. 
This book shows how new technologies have led to a better understanding of these processes and their connected diseases.
The book is written for scientists in fundamental and applied biomedical research working on different aspects of gene regulation. It is also targeted to an audience that is not implicated in these fields directly, but wants to gain a better understanding of mRNA biology.

• mRNA
• R-loops
• RNA granules
• RNA binding proteins
• RNPs
• RNA structure
• structural biology
• transcription
• mRNA translation
• gene regulation
• mRNA editing
• messenger RNA
• genetic information
• mRNA imaging
• messenger ribonucleoprotein particle
• gene expression
• Protein-Ligand Interactions

• Systems biology (IRCM), Biochemistry and Molecular Medicine (UdeM), Experimental Medicine (McGill), Institut de recherches cliniques de Montréal (IRCM), Université de Montréal, McGill University, Montreal, Canada

  Marlene Oeffinger

• Department of Biochemistry and Molecular Medicine, Université de Montréal, Montréal, Canada

  Daniel Zenklusen

Marlene Oeffinger is Associate Research Professor at the Institut de recherches cliniques de Montréal (IRCM) and the Department of biochemistry and molecular medicine at the Université de Montréal in Montréal, Canada, and Adjunct Professor in the Division of Experimental Medicine at McGill University. Her laboratory uses Proteomic, RNomic and biochemical approaches to study the regulation, dynamics and functional niches of RNA maturation pathways and their implications in neurodegenerative diseases.

Daniel Zenklusen is an Associate Professor at the Department of biochemistry and molecular medicine at the Université de Montréal in Montréal, Canada. His laboratory uses single molecule and super-resolution microscopy approaches to study different aspects of gene expression in single cells, including RNA transport and localization, lncRNAs function and mRNP organization.

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