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Topics in Medicinal Chemistry

Structure and Function of GPCRs

Editors: Lebon, Guillaume (Ed.)

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  • Reviews the structural basis of ligand binding and allosteric mechanisms
  • Presents concrete examples of structure-based drug discovery
  • Illustrates GPCR biased signaling in physiological contexts
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eBook 178,49 €
price for Spain (gross)
  • ISBN 978-3-030-24591-7
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Hardcover 228,79 €
price for Spain (gross)
  • ISBN 978-3-030-24589-4
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  • Usually dispatched within 3 to 5 business days.
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About this book

This book introduces readers to the latest advances in G protein-coupled receptor (GPCR) biology. It reviews our current understanding of the structural basis of ligand binding and allosteric mechanisms, following a decade of technological breakthroughs. Several examples of structure-based drug discovery are presented, together with the future challenges involved in designing better drugs that target GPCRs. In turn, the book illustrates the important concept of GPCR biased signaling in physiological contexts, and presents fluorescent- and light-based methodologies frequently used to measure GPCR signaling or to trace their dynamics in cells upon ligand activation. 
Taken together, the chapters provide an essential overview and toolkit for new scientific investigators who plan to develop GPCR projects. All chapters were written by experts in their respective fields, and share valuable insights and powerful methodologies for the GPCR field.

Table of contents (10 chapters)

Table of contents (10 chapters)

Buy this book

eBook 178,49 €
price for Spain (gross)
  • ISBN 978-3-030-24591-7
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover 228,79 €
price for Spain (gross)
  • ISBN 978-3-030-24589-4
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
  • The final prices may differ from the prices shown due to specifics of VAT rules
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Bibliographic Information

Bibliographic Information
Book Title
Structure and Function of GPCRs
Editors
  • Guillaume Lebon
Series Title
Topics in Medicinal Chemistry
Series Volume
30
Copyright
2019
Publisher
Springer International Publishing
Copyright Holder
Springer Nature Switzerland AG
eBook ISBN
978-3-030-24591-7
DOI
10.1007/978-3-030-24591-7
Hardcover ISBN
978-3-030-24589-4
Series ISSN
1862-2461
Edition Number
1
Number of Pages
XIV, 289
Number of Illustrations
19 b/w illustrations, 52 illustrations in colour
Topics