- Provides the fundamental basic and applied clinical science at the cutting edge of CSS treatment
- First textbook devoted to Cytokine Storm Syndromes, covering all aspects of the disorder (clinical, genetics, pathophysiology, associations, therapy, and others)
- Extensive panel of contributing authors, made up of internationally-renowned experts in CSS research
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- About this book
-
Cytokine Storm Syndromes, including HLH and MAS, are frequently fatal disorders, particularly if not recognized early and treated during presentation. The genetics of Cytokine Storm Syndromes are being defined with many of the risk alleles giving rise to mutations in the perforin-mediated cytolytic pathway used by CD8 cytotoxic T cells and natural killer cells. These are being studied using murine models. Up to 10% of the general population may carry risk alleles for developing Cytokine Storm Syndromes, and Cytokine Storm Syndromes are being increasingly recognized around the world in pediatric and adult hospitals.
A variety of infectious, rheumatic, and oncologic triggers are commonly associated with Cytokine Storm Syndromes, but understanding this disorder is critical for all researchers and physicians to ensure timely and appropriate therapy. This textbook, the first of its kind, addresses all aspects of the disorder – from genetics, pathophysiology, and ongoing research, to clinical presentations, risk factors, and treatment.
- About the authors
-
Randy Q. Cron, MD, PhD
University of Alabama at Birmingham
Professor of Pediatrics and Medicine
Birmingham
Alabama
USA
Edward M. Behrens, MD
University of Pennsylvania Perelman School of Medicine
Perelman School of Medicine
Philadelphia
Pennsylvania
USA
- Table of contents (35 chapters)
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History of Hemophagocytic Lymphohistiocytosis
Pages 3-16
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The History of Macrophage Activation Syndrome in Autoimmune Diseases
Pages 17-29
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Clinical Features of Cytokine Storm Syndrome
Pages 31-41
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Laboratory Features and Pathology of the Cytokine Storm Syndromes
Pages 43-59
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Criteria for Cytokine Storm Syndromes
Pages 61-79
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Table of contents (35 chapters)
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Bibliographic Information
- Bibliographic Information
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- Book Title
- Cytokine Storm Syndrome
- Editors
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- Randy Cron
- Edward M. Behrens
- Copyright
- 2019
- Publisher
- Springer International Publishing
- Copyright Holder
- Springer Nature Switzerland AG
- eBook ISBN
- 978-3-030-22094-5
- DOI
- 10.1007/978-3-030-22094-5
- Hardcover ISBN
- 978-3-030-22093-8
- Edition Number
- 1
- Number of Pages
- XXI, 617
- Number of Illustrations
- 6 b/w illustrations, 25 illustrations in colour
- Topics
