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Handbook of Experimental Pharmacology

Bile Acids and Their Receptors

Editors: Fiorucci, Stefano, Distrutti, Eleonora (Eds.)

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  • Gives an overview on latest findings in the novel field of research of bile acids as signaling molecules  
  • Offers a cross-country view of the functional role of bile acids as signaling molecules,  virtuallyacting on all major areas of metabolism
  • Describes different approaches of bile acids pharmacology by providing authors' diverse perspectives  
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price for Spain (gross)
  • ISBN 978-3-030-22005-1
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About this book

This book focusses on the latest results related to the field of  bile acids as signaling molecules  and describes how these receptors have become a major pharmacological target. It covers all major areas of research in this field, from genetics, chemistry, in silico modeling, molecular biology to clinical applications, offering a cross-country view of the functional role of bile acids as signaling molecules, virtually acting on all major areas of metabolism. While FXR  and GPBAR1 are essential bile acid sensors that  integrate the de novo bile acid synthesis with intestinal microbiota and  liver metabolism, in a broader sense,  BARs  play a pathogenic role in the development of common human alignments  including  liver, intestinal and metabolic disorders, such as steatosis (NAFLD) and steato-hepatitis (NASH), diabetes, obesity and atherosclerosis. 

Table of contents (15 chapters)

Table of contents (15 chapters)
  • The Pharmacology of Bile Acids and Their Receptors

    Pages 3-18

    Fiorucci, Stefano (et al.)

  • Bile Acid-Activated Receptors: GPBAR1 (TGR5) and Other G Protein-Coupled Receptors

    Pages 19-49

    Keitel, Verena (et al.)

  • Bile Acid-Activated Receptors: A Review on FXR and Other Nuclear Receptors

    Pages 51-72

    Shin, Dong-Ju (et al.)

  • The Enterokine Fibroblast Growth Factor 15/19 in Bile Acid Metabolism

    Pages 73-93

    Cariello, Marica (et al.)

  • Signaling from Intestine to the Host: How Bile Acids Regulate Intestinal and Liver Immunity

    Pages 95-108

    Biagioli, Michele (et al.)

Buy this book

eBook 117,69 €
price for Spain (gross)
  • ISBN 978-3-030-22005-1
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover 155,99 €
price for Spain (gross)
  • ISBN 978-3-030-22004-4
  • Free shipping for individuals worldwide
  • Immediate ebook access, if available*, with your print order
  • Usually dispatched within 3 to 5 business days.
  • The final prices may differ from the prices shown due to specifics of VAT rules
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Bibliographic Information

Bibliographic Information
Book Title
Bile Acids and Their Receptors
Editors
  • Stefano Fiorucci
  • Eleonora Distrutti
Series Title
Handbook of Experimental Pharmacology
Series Volume
256
Copyright
2019
Publisher
Springer International Publishing
Copyright Holder
Springer Nature Switzerland AG
eBook ISBN
978-3-030-22005-1
DOI
10.1007/978-3-030-22005-1
Hardcover ISBN
978-3-030-22004-4
Series ISSN
0171-2004
Edition Number
1
Number of Pages
X, 378
Number of Illustrations
20 b/w illustrations, 37 illustrations in colour
Topics

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