Direct Mechanisms in Cholesterol Modulation of Protein Function
Editors: Rosenhouse-Dantsker, Avia, Bukiya, Anna N. (Eds.)
Free Preview- Very timely topic as cholesterol, increasingly, has been implicated as a major regulator of protein function
- Contributors are well-known experts in their fields and provide international perspective
- Research will be invaluable across several areas from biochemistry to nutrition
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- About this book
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In this book, renowned scientists describe how cholesterol interacts with various proteins. Recent progress made in the high-resolution visualization of cholesterol-protein interactions using crystallography and cryogenic electron microscopy has substantially advanced the knowledge of critical features. These features enable specific recognition of the cholesterol molecule by proteins, a process that was built on earlier studies using binding assays, computational modeling and site-directed mutagenesis.
Direct Mechanisms in Cholesterol Modulation of Protein Function offers comprehensive insights into the current understanding of cholesterol-driven modulation of protein function via direct sensing. Its nine chapters are organized into two distinct parts. In the first part, the chapters introduce the reader to the general characteristics of cholesterol binding sites in proteins. This part starts with a tour into common cholesterol recognition motifs, followed by an overview of the major classes of steroid-binding proteins. It then continues with two chapters that present a comprehensive analysis of molecular and structural characteristics of cholesterol binding sites in transmembrane and soluble protein domains. In the second part of the book, examples of cholesterol binding sites and consequences of specific cholesterol recognition for protein function are presented for G protein-coupled receptors, ion channels and cholesterol-transporting proteins.
The book is valuable for undergraduate and graduate students in biochemistry and nutrition, as well as basic science and medical researchers with a keen interest in the biophysical properties of cholesterol and physiological consequences of cholesterol presence in biological systems.
- Table of contents (8 chapters)
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Cholesterol-Recognition Motifs in Membrane Proteins
Pages 3-25
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Crystallographic Studies of Steroid-Protein Interactions
Pages 27-45
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Molecular Determinants of Cholesterol Binding to Soluble and Transmembrane Protein Domains
Pages 47-66
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Modes of Cholesterol Binding in Membrane Proteins: A Joint Analysis of 73 Crystal Structures
Pages 67-86
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Effects of Cholesterol on GPCR Function: Insights from Computational and Experimental Studies
Pages 89-103
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Table of contents (8 chapters)
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Bibliographic Information
- Bibliographic Information
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- Book Title
- Direct Mechanisms in Cholesterol Modulation of Protein Function
- Editors
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- Avia Rosenhouse-Dantsker
- Anna N. Bukiya
- Series Title
- Advances in Experimental Medicine and Biology
- Series Volume
- 1135
- Copyright
- 2019
- Publisher
- Springer International Publishing
- Copyright Holder
- Springer Nature Switzerland AG
- eBook ISBN
- 978-3-030-14265-0
- DOI
- 10.1007/978-3-030-14265-0
- Hardcover ISBN
- 978-3-030-14264-3
- Softcover ISBN
- 978-3-030-14267-4
- Series ISSN
- 0065-2598
- Edition Number
- 1
- Number of Pages
- IX, 168
- Number of Illustrations
- 1 b/w illustrations, 50 illustrations in colour
- Topics
