Advances in Anatomy, Embryology and Cell Biology

The Origin of a New Progenitor Stem Cell Group in Human Development

An Immunohistochemical-, Light- and Electronmicroscopical Analysis

Authors: Wartenberg, Hubert, Miething, Andreas, Møllgård, Kjeld

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  • Comprehensive overview of a new group of human progenitor stem cells
  • Highlights that these newly detected stem cells represent a specific developmental step which is found only in humans.
  • Detailed description of the development and formation of the different types of stem cells
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eBook 85,59 €
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  • ISBN 978-3-030-02050-7
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Softcover 103,99 €
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  • ISBN 978-3-030-02049-1
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About this book

This book presents an overview of a new group of progenitor stem cells. Their origins were originally detected in light- and electron microscopical sections of plastic embedded human embryonal and fetal organs.

The distribution of these cells can result in a large quantity of ectopic stem cells. The observation of these ectopic stem cells leads us to postulate the existence of a basic wave of stem cell progenitors. This process proceeds earlier and independently from germ cell migration. This first wave of progenitor stem cell migration initially reaches the peri-aortal AMG-region (Aortal-Mesonephric-Gonadal region). From here, some of these progenitor cells enter the aorta, are distributed through the vascular system and become the embryonal stem cells (reserve cells) in many peripheral tissues. A second part delivers progenitor cells for the adrenal 'anlage'. Within the peripheral Zona definitiva of the adrenal cortex the progenitor cells multiplicate and subsequently leave the adrenal cortex through a gate of the capsule. The progenitor cells arrive at the pre-aortal sympathic plexus ('second brain'). Within the plexus ganglia they form new organ-like clusters, the paraganglia. In a second process the progenitor cells (Chromaffine cells) enter sympathetic nerve bundles. Here an 'axonal migration' starts, which guides the progenitor cells to several peripheral organs. During this migration process the stem cells develop into their final state. In the adrenal cortex the ingrowing nerves guide the stem cells to the adrenal medulla. In the pancreas the ingrowing nerve fibers guide the stem cells to the islets. 

These newly detected stem cells represent a specific developmental step which is found only in humans. 

Reviews

“This expert‐level book is most appropriate for developmental biologists with an understanding of embryology and histology. … The book includes numerous light‐ and electron‐microscope images that complement the main points. … This monograph offers a unique hypothesis on the origin and migration of a newly identified source of fetal stem cells.” (Erin Rae Leslie, Doody's Book Reviews, June 07, 2019)


Table of contents (1 chapters)

Table of contents (1 chapters)
  • The Origin of a New Progenitor Stem Cell Group in Human Development

    Pages 1-70

    Wartenberg, Hubert (et al.)

Buy this book

eBook 85,59 €
price for Spain (gross)
  • ISBN 978-3-030-02050-7
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Softcover 103,99 €
price for Spain (gross)
  • ISBN 978-3-030-02049-1
  • Free shipping for individuals worldwide
  • Institutional customers should get in touch with their account manager
  • Shipping restrictions
  • Usually ready to be dispatched within 3 to 5 business days, if in stock
  • The final prices may differ from the prices shown due to specifics of VAT rules
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Bibliographic Information

Bibliographic Information
Book Title
The Origin of a New Progenitor Stem Cell Group in Human Development
Book Subtitle
An Immunohistochemical-, Light- and Electronmicroscopical Analysis
Authors
Series Title
Advances in Anatomy, Embryology and Cell Biology
Series Volume
230
Copyright
2019
Publisher
Springer International Publishing
Copyright Holder
Springer Nature Switzerland AG
eBook ISBN
978-3-030-02050-7
DOI
10.1007/978-3-030-02050-7
Softcover ISBN
978-3-030-02049-1
Series ISSN
0301-5556
Edition Number
1
Number of Pages
XII, 79
Number of Illustrations
76 b/w illustrations, 2 illustrations in colour
Topics