- Written by leading scientists who apply quantitative systems methodology in their biological research
- Covers a broad range of methods with a proven record of application to a wide variety of biomedical research problems
- Contains step-by-step instructions for implementing computational techniques, much like in a laboratory protocol
- Addresses the caveats of applying the systems analysis to biology from the practical researcher’s standpoint
- Offers uniquely broad coverage of quantitative methods that account for the complex structural organization in biological systems
Buy this book
- About this book
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The rapidly developing methods of systems biology can help investigators to make inference and predictions from their data that intuition alone would not discern; however, the difficulty lies in the broad knowledge of mathematics and engineering that seems to be required to even evaluate the applicability of the methods to the problem at hand. In Systems Biology, scientists who possess that mathematical knowledge and have applied it effectively to various biological problems contribute methods which reflect their experience, crystallized in a form very similar to typical biological laboratory protocols. In order to best aid researchers, the chapters supply the theory behind the method, its step-by-step implementation, and the pitfalls explained thoroughly and from the practical angle. As a volume of the highly successful Methods in Molecular Biology™ series, this work provides the kind of detailed description and implementation advice that is crucial for getting optimal results.
Cutting-edge and easy to use, Systems Biology shatters the perceived insurmountable barrier between the laboratory and systems-biological research techniques.
- Reviews
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From the reviews: “This volume considers systems biology in the broadest terms: the integration of experimental and mathematical approaches to biological systems with the aim of gaining both predictive and explanatory power. … the methods are clearly explained and well-illustrated … . Therefore, this volume will generally be of most value as an institutional purchase.” (Conrad Nieduszynski, Microbiology Today, January, 2010)
- Table of contents (16 chapters)
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Introduction: A Practical Guide to the Systems Approach in Biology
Pages 1-11
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Computational Modeling of Biochemical Networks Using COPASI
Pages 17-59
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Flux Balance Analysis: Interrogating Genome-Scale Metabolic Networks
Pages 61-80
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Modeling Molecular Regulatory Networks with JigCell and PET
Pages 81-111
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Rule-Based Modeling of Biochemical Systems with BioNetGen
Pages 113-167
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Table of contents (16 chapters)
- Download Preface 1 PDF (65.8 KB)
- Download Sample pages 1 PDF (1.2 MB)
- Download Table of contents PDF (93.2 KB)
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Bibliographic Information
- Bibliographic Information
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- Book Title
- Systems Biology
- Editors
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- Ivan V. Maly
- Series Title
- Methods in Molecular Biology
- Series Volume
- 500
- Copyright
- 2009
- Publisher
- Humana Press
- Copyright Holder
- Humana Press
- Distribution Rights
- Distribution rights for India: Atlantic Pub. & Distr. (P) Ltd., New Delhi, India
- eBook ISBN
- 978-1-59745-525-1
- DOI
- 10.1007/978-1-59745-525-1
- Hardcover ISBN
- 978-1-934115-64-0
- Softcover ISBN
- 978-1-62703-949-9
- Series ISSN
- 1064-3745
- Edition Number
- 1
- Number of Pages
- XI, 500
- Topics
