Cancer Drug Discovery and Development

Chemokine Receptors in Cancer

Editors: Fulton, Amy (Ed.)

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  • Cumulatively, these data indicate that chemokine receptors may serve as biomarkers of tumor behavior as well as potential therapeutic targets
  • Now is an appropriate time to summarize what we do and do not know about the role of chemokine receptors in cancer behavior
  • Further studies are needed to understand the mechanisms by which these receptors contribute to tumor behavior, how receptor expression is regulated and to identify strategies to more effectively target these receptors
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eBook 154,69 €
price for Spain (gross)
  • ISBN 978-1-60327-267-4
  • Digitally watermarked, DRM-free
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  • Immediate eBook download after purchase
Hardcover 207,99 €
price for Spain (gross)
  • ISBN 978-1-60327-266-7
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
  • The final prices may differ from the prices shown due to specifics of VAT rules
Softcover 194,38 €
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  • ISBN 978-1-61737-885-0
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  • Usually dispatched within 3 to 5 business days.
  • The final prices may differ from the prices shown due to specifics of VAT rules
About this book

Chemokine Receptors in Cancer summarizes the growing body of evidence that several chemokine receptors contribute to tumor behavior. Chemokine receptors were first identified on leukocytes and mediate directed migration of many host cells to sites of ligand expression. It is now well established that most malignant cells also express one or more chemokine receptor. This book describes our current understanding regarding how chemokine receptors contribute to tumor cell migration as well as cell survival and proliferation. The function of chemokine receptors expressed on host cells including antitumor immune effector cells as well as angiostatic and angiogeneic functions of chemokines acting on endothelial cells are described. The role of chemokine receptors that act as decoy receptors is also summarized. The therapeutic potential and challenges of targeting chemokine receptors or cognate ligands is also addressed.

Reviews

From the reviews:

“This book will appeal to a broad audience. It is useful for anyone who is interested in the area of chemokines and their receptors in cancer, including students, established investigators, and clinicians. … The book provides a nice, concise summary of the evidence for the role of chemokine receptors in cancer. … this book largely focuses on the role of chemokine receptors on tumor cells themselves and effects on angiogenesis, progression, and metastasis, adding significantly to our current knowledge about cancer.” (Cheryl E. Rockwell, Doody’s Review Service, December, 2009)

“Report the progress of chemokine and chemokine receptor study in cancer-therapy-related research. … provides an overview that is useful not only to researchers focusing on cancer immunology research, but also to graduate students and postdoctoral associates who have just started working in this area. … the book not only attractive to cancer biologists, but also to medicinal chemists and pharmacologists working in the field of anticancer drug discovery. … applied as a reasonable starting point for cancer researchers to grasp the progress in this area.” (Yan Zhang, ChemMedChem, Vol. 5, 2010)


Table of contents (9 chapters)

Table of contents (9 chapters)

Buy this book

eBook 154,69 €
price for Spain (gross)
  • ISBN 978-1-60327-267-4
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover 207,99 €
price for Spain (gross)
  • ISBN 978-1-60327-266-7
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
  • The final prices may differ from the prices shown due to specifics of VAT rules
Softcover 194,38 €
price for Spain (gross)
  • ISBN 978-1-61737-885-0
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
  • The final prices may differ from the prices shown due to specifics of VAT rules
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Bibliographic Information

Bibliographic Information
Book Title
Chemokine Receptors in Cancer
Editors
  • Amy Fulton
Series Title
Cancer Drug Discovery and Development
Copyright
2009
Publisher
Humana Press
Copyright Holder
Humana Press
eBook ISBN
978-1-60327-267-4
DOI
10.1007/978-1-60327-267-4
Hardcover ISBN
978-1-60327-266-7
Softcover ISBN
978-1-61737-885-0
Series ISSN
2196-9906
Edition Number
1
Number of Pages
VIII, 172
Number of Illustrations
13 b/w illustrations
Topics